DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8945 and T06A4.1

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_871809.1	Gene:	T06A4.1 / 171669	WormBaseID:	WBGene00020281	Length:	606	Species:	Caenorhabditis elegans

Alignment Length:	463	Identity:	127/463 - (27%)
Similarity:	216/463 - (46%)	Gaps:	73/463 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   981 YDKYQIWRLKPQDEEQVRALEEFKKGEDGVKLQ-WLKGPSLRGLTDVLVPPKMLVDFQGTLNYEG 1044
            |..:::.|:.|:.|..|:.|....:.....:|. |....::..:.|:.|.|.....|...|..:.
Worm    29 YHNFKLIRINPETEGSVKYLRSLYEDPSPYELDFWQPPTNIGAIVDLTVAPADAPRFVKDLESKK 93

  Fly  1045 IAHEVLIFDVGKAIAYELTKEDYLQTTRPSKPRPTAPPPMTWNRYHNHDEIVKYLETVRMRHPQL 1109
            |::.|.:.|:.|||..|...:.:.        .|.|  ...:::|::.:||...::.::..:|.:
Worm    94 ISYIVAVNDLSKAIENERGSDKFY--------NPVA--GFAYDKYNSLEEIQTEMKRLKKEYPTM 148

  Fly  1110 VELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSGQANAVFVEAGAQGLAWIG 1174
            :.||.||:|.|.|.|:|:||..|                   :...|...:::::||.....||.
Worm   149 ITLIDIGQSHENRTLLVMKITGK-------------------RNPLGSKISMWIDAGIHAREWIA 194

  Fly  1175 PAAATWMIAELLRLMKTN----KSNEDVEFIRNTTWYIMPVLNPDGYAYSHEYDRFWKKSRSQHQ 1235
            ||.|.::..|||...:.:    |..:.::|      ||:||:|||||.||.|.:|.|:|:||
Worm   195 PATAMYIAHELLLGYENDATVAKLMDHIDF------YILPVMNPDGYEYSREKNRMWRKNRS--- 250

  Fly  1236 TPPPSGLLDSAMTWLQQKRGPDKVCYGVDLDRNWLYHWGKRGSSKAPCNEFYAGPAPFSEPETKA 1300
               |:.......:.:        .|.||||:||:.:.|...|||..||::.|.|.|.|||||::|
Worm   251 ---PAKCARQTFSTV--------CCSGVDLNRNFDWFWASTGSSSDPCHDTYHGSAAFSEPESQA 304

  Fly  1301 VSEFLMDYRTQIKLYISLQAYGQVISYPVKANSTFNSERLDDFLDVAMVGTDGLRKKGSK----- 1360
            |.:|| :..|. :.:|||.:|.|:...|.       ..|...:......|...|..:.:|
Worm   305 VRDFL-EQNTP-EAFISLHSYSQMWLIPY-------GHRKQSYPQDYHTGLRPLALRATKALYEL 360

  Fly  1361 --SRYKVDASNDLIEQRSGCADAFAAYEIGIPFSYTLQLADNGV---HGYLLPSSAIEPTARDAF 1420
              ::|:|....||:.:.||.:..:|..::.:|::|.::|.....   ||:|||...|.||..:.|
Worm   361 YGTKYQVGTGADLMYEASGGSHDWAKGQLKVPYAYLIELRPKNTMMGHGFLLPEREIVPTGLETF 425

  Fly  1421 EIISGMLD 1428
            |.|..:.|
Worm   426 ESIKVVAD 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	16/70 (23%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	105/354 (30%)
T06A4.1	NP_871809.1	Propep_M14	40..110	CDD:366995	16/69 (23%)
		M14_CP_A-B_like	128..435	CDD:349433	105/354 (30%)
		ShK	568..602	CDD:366702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11705
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020