DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8945 and AGBL1

DIOPT Version :9

Sequence 1:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001373023.1	Gene:	AGBL1 / 123624	HGNCID:	26504	Length:	1121	Species:	Homo sapiens

Alignment Length:	879	Identity:	163/879 - (18%)
Similarity:	267/879 - (30%)	Gaps:	292/879 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   620 MSDGDYEDEGEEEEEEQDDDEDYYFEDEHKDEDKNKPNESSSTEVGQSDLK-------EDSSSAE 677
            :.:.|:||:|::|.::..|.||...||:..:.|.||.:.....:..:.:|.       |.|.|.|
Human   298 LPEEDFEDDGDDEVDKDSDTEDGKVEDDDLETDVNKLSSKPGLDRPEEELMQYEVMCLELSYSFE 362

  Fly   678 E-GADFGAMVEEETTTTATISSSEELDATSSTKNSMAKKKIRIKRRPVDSDEDYDDDEDSGIAGF 741
            | .:..|..:..|.|..|   :...:.|.:|:|...                 |..|:.|  .|.
Human   363 ELQSKLGDDLNSEKTQYA---NHHHIPAAASSKQHC-----------------YSKDQSS--CGQ 405

  Fly   742 FRMIFYPVQVA-MSRLMDGFGTPDEEEDKEPATQPVSKYPSYTLYHSAHSNEAYAEPDDEDSEDD 805
            .|.  |.||.: :.|:..|..|......|.|..         .||.:..||....:..:.:..|.
Human   406 ERE--YAVQTSLLCRVKTGRSTVHLGSKKNPGV---------NLYQNVQSNSLRRDSSESEIPDI 459

  Fly   806 EDSSSLGSWFGSWFGLQRRTKKIGSTTTTMPVPLPPPTKAPPSWLESWFGFGSTTEADAEDDYDK 870
            :.|....:|........|.:....::|.|..|     .|.....|:        |.......:|.
Human   460 QASPKADAWDVDAIFCPRMSASFSNSTRTREV-----VKVIDKLLQ--------THLKRVPFHDP 511

  Fly   871 WFSSWFDSRPKRKFRRRSTTSTSTTSTTTTTHTPSAAAAQVPILTIVD--PLRNPQNWIGILAHH 933
            :..       ..|.||.|                          ::||  .:..|..|    .|
Human   512 YLY-------MAKARRTS--------------------------SVVDFKMMAFPDVW----GH- 538

  Fly   934 IVNSTGSAISTSTSNPLLQALATRMTTRGTTSTTTTTSRPDVPRRISYDKYQIWRLKPQDEEQVR 998
                    ....|:.|:|:........|............||..::.:...:.|.|:......:|
Human   539 --------CPPPTTQPMLERKCGVQRIRIFEDIRRLIQPSDVINKVVFSLDEPWPLQDNASNCLR 595

  Fly   999 ALEEFKKGEDGVKLQWLKGPSLRGLT-DVLVPPKMLVDFQGTLNYEGIAHEVLIFDVGKAIAYEL 1062
            ...:|:.|      ...|...:|... |:||.    .|...|.:.:....:|  ..:..||.|..
Human   596 FFSKFESG------NLRKAIQVREFEYDLLVN----ADVNSTQHQQWFYFKV--SGMQAAIPYHF 648

  Fly  1063 ---------TKEDY-LQTTRPSKPRPTAPPPMTWNR-------YHN------------------- 1091
                     ::.:| :|.|..|........| ||.|       |.|
Human   649 NIINCEKPNSQFNYGMQPTLYSVKEALLGKP-TWIRTGHEICYYKNHYRQSTAVAGGASGKCYYT 712

  Fly  1092 --------HDEIVKYLE-------TVRMRHPQLVEL------IH-----IGRSFEGRPLIVVKIE 1130
                    |.|.|.||.       |..|.|..::|.      ::     :.::..|.|..:|.|
Human   713 LTFAVTFPHSEDVCYLAYHYPYTYTALMTHLDILEKSVNLKEVYFRQDVLCQTLGGNPCPLVTI- 776

  Fly  1131 SKQTAAAANNDGLHTIKRPKRKRKSGQANAVFVEAGAQGLAWIGPAAATWMIAE--LLRLMKTNK 1193
               ||...:|...|.   .:.:.:..|.....|..|....:|:......::::.  :.||::.|
Human   777 ---TAMPESNSDEHL---EQFRHRPYQVITARVHPGESNASWVMKGTLEFLVSSDPVARLLREN- 834

  Fly  1194 SNEDVEFIRNTTWYIMPVLNPDGYAYSHEYDRFWKKSRSQHQTPPPSGLLDSAMTWLQQKRGPDK 1258
                  ||    :.|:|:|||||..            ...|:
Human   835 ------FI----FKIIPMLNPDGVI------------NGNHR----------------------- 854

  Fly  1259 VC--YGVDLDRNW-----------------LYHWGKRGSSKAPCNEFYAGPAPFSEPETKAVSEF 1304
             |  .|.||:|.|                 |||....|.|.....:|:.        .::..:.|
Human   855 -CSLSGEDLNRQWLSPSAHLQPTIYHAKGLLYHLSSIGRSPVVFCDFHG--------HSQKKNVF 910

  Fly  1305 LMDYRTQIK--LYISLQAYGQVISYPVKANSTF----NSERLDDFLDVAMVGTDGLRKKGSKSRY 1363
            |  |...||  |:.:....|         .||.    |...|...||..            ...:
Human   911 L--YGCSIKETLWQAACTVG---------TSTILEEVNYRTLPKILDKL------------APAF 952

  Fly  1364 KVDASNDLIEQ-RSGCADAFAAYEIGIPFSYTLQ 1396
            .:.:.:.|:|: |:..|......|:|:..|||::
Human   953 TMSSCSFLVEKSRASTARVVVWREMGVSRSYTME 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8945	NP_573190.1	Propep_M14	988..1058	CDD:280416	12/70 (17%)
CG8945	NP_573190.1	M14_CP_A-B_like	1089..1430	CDD:199844	70/381 (18%)
AGBL1	NP_001373023.1	Pepdidase_M14_N	596..730	CDD:407865	28/146 (19%)
AGBL1	NP_001373023.1	M14_Nna1	754..1019	CDD:349477	59/318 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900