Protein Alignment CG45002 and DPP6

DIOPT Version :10

• Sequence 1: NP_728041.3
• Gene: CG45002 / 32688
• FlyBaseID: FBgn0266354
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_570629.2
• Gene: DPP6 / 1804
• HGNCID: 3010
• Length: 865
• Species: Homo sapiens
• Alignment Length: 956
• Identity: 247/956 - (25%)
• Similarity: 412/956 - (43%)
• Gaps: 213/956 - (22%)

  Fly    38 KDEELVAISPERRNWRGIFIALLVIAAVFSLIIFSIFLLSPEDEGLRIRGRRMLPSDILGRSLQW 102
            :::|||..:|.:|||:||.||||||..:.|||:.|:.||:|.::....:.:::...|:.....:.
Human    79 EEDELVGSNPPQRNWKGIAIALLVILVICSLIVTSVILLTPAEDNSLSQKKKVTVEDLFSEDFKI 143

  Fly   103 KPFNGTWSNGRELIYRDPTGGLSILNMADLTTRILMTNSTFRQLNAESFLVAPDQKYVLLQSDSN 167
            ......|.:..|.|||:..|.:.:.|:...|:.:|:.......|.|..:.::||::|.|.  ..|
Human   144 HDPEAKWISDTEFIYREQKGTVRLWNVETNTSTVLIEGKKIESLRAIRYEISPDREYALF--SYN 206

  Fly   168 AEGSRHHVY-------EVQTANTFPLGPTENIAEAPRLQHVVWAPANPPPPLGAPPPSGASGASG 225
            .|....|.|       ::...:...|.|.| ::.| :||:..|.|.
Human   207 VEPIYQHSYTGYYVLSKIPHGDPQSLDPPE-VSNA-KLQYAGWGPK------------------- 250

  Fly   226 ASGASTTTMAPLPSGSIILNSLAGAANGPASAGASGSSAPNPNGKAGGYNLNQAIAFVHHNDIYY 290
                                                               .|.:.|:..|:|||
Human   251 ---------------------------------------------------GQQLIFIFENNIYY 264

  Fly   291 KPKVQGELVCRITQTGSGSLEGESTGVVFNGVPDWMYENVPELESRRSSMEFSPDGLFLAFLSYN 355
            ...| |:...|:..||       ..||::||:.||:||.  |:.....:..:||||..||:.:.|
Human   265 CAHV-GKQAIRVVSTG-------KEGVIYNGLSDWLYEE--EILKTHIAHWWSPDGTRLAYAAIN 319

  Fly   356 DSEVNEYKY-TWMGDDIKYPAVMSQRYPKTGSRNPNVTVNVVNLSVIKYIFPT---QIKLPSE-L 415
            ||.|...:. |:.|.  .||.|....|||.||.||:::::|:.|:     .||   ::..|.: .
Human   320 DSRVPIMELPTYTGS--IYPTVKPYHYPKAGSENPSISLHVIGLN-----GPTHDLEMMPPDDPR 377

  Fly   416 SNGSYVGGLTWASSTDLSVTVTNREQTKATTVLCRAPHFHCQAVHTEVTINDGWV-LPSERPIFS 479
            ....|:..:.||:||.::||..||.|..:...||.|....|...|.:.  ::.|: ..:|.|:||
Human   378 MREYYITMVKWATSTKVAVTWLNRAQNVSILTLCDATTGVCTKKHEDE--SEAWLHRQNEEPVFS 440

  Fly   480 VRNQGHNRLGKMVQNAEEIQAESQNVNVTDGQTHTTHEISNGGYLLKRLPVRDGEHGHYRHVVFI 544
                                        .||:..         :.::.:|  .|..|.:.|:...
Human   441 ----------------------------KDGRKF---------FFIRAIP--QGGRGKFYHITVS 466

  Fly   545 SSLDRRP-------VPLTMGRFEVTEIVGWDEPHEIVYFMAAPEKRPGERHLYKISLKLNVTESN 602
            ||   :|       ..:|.|.::||:|:.:||....:||::. |..|..|.||..:   .|...|
Human   467 SS---QPNSSNDNIQSITSGDWDVTKILAYDEKGNKIYFLST-EDLPRRRQLYSAN---TVGNFN 524

  Fly   603 RTYITSTSPTCLTCDNTESTYRLHRARISQRGDRWEDIVARLEPDDCLYDIPKNCLFNRVQFSQD 667
            |        .||:||..|                                   ||.:....||..
Human   525 R--------QCLSCDLVE-----------------------------------NCTYFSASFSHS 546

  Fly   668 YSYYVQECLGPEAPSVYLVETASNDKIYVLNAGDVLRHRLSQLAIPQSRTFSVEIRHGFHAQVRL 732
            ..:::.:|.||..|.|.:..|....|::.|...:.::..::...:|:.....:|| ..::..:::
Human   547 MDFFLLKCEGPGVPMVTVHNTTDKKKMFDLETNEHVKKAINDRQMPKVEYRDIEI-DDYNLPMQI 610

  Fly   733 FLPPGMREEEDVAFPLVLHVDASPGSQLVTERFHVDWNWYLASQRSFIVAQIDGRGSGFQGELLR 797
            ..|...  .:...:||:|.||.:||||.|.|:|.|.|...:.|....:|.:.|||||||||..|.
Human   611 LKPATF--TDTTHYPLLLVVDGTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLL 673

  Fly   798 TQVHGKLGTVEVEDQL-GVLTYLRDNLKFIDPLRICAFGWGYGGYASSMMLI---DDSQQVLQCA 858
            .:|..:||.:|.:||: .|.|.|::  ::||..|:..||..||||.|:.:|.   ::..|...|.
Human   674 HEVRRRLGLLEEKDQMEAVRTMLKE--QYIDRTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCG 736

  Fly   859 VAINPIVNFGFHYSFFTERYIPLKGDYLRALQEADLTMKAGNIKGRNLMLMHGTADTLVHQEHTL 923
            .|::||.:|..:.|.|:|||:.|.|...||.:...:..:...::.:..:::|.|||..:|.:||.
Human   737 SALSPITDFKLYASAFSERYLGLHGLDNRAYEMTKVAHRVSALEEQQFLIIHPTADEKIHFQHTA 801

  Fly   924 MLVRALVEQQVKFRHQVYPDEDHAIARS--LSHVYKTMEWYFDECF 967
            .|:..|:..:..:..|:||||.|....|  ..|:|:::..:|.|||
Human   802 ELITQLIRGKANYSLQIYPDESHYFTSSSLKQHLYRSIINFFVECF 847

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45002	NP_728041.3	DPPIV_N	278..681	CDD:395744	105/415 (25%)
		Peptidase_S9	765..969	CDD:459761	72/209 (34%)
DPP6	NP_570629.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..88		3/8 (38%)
		DPPIV_N	195..561	CDD:395744	121/547 (22%)
		Peptidase_S9	641..847	CDD:459761	70/207 (34%)