DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ubr1 and UBR1

DIOPT Version :9

Sequence 1:	NP_001245723.1	Gene:	Ubr1 / 32687	FlyBaseID:	FBgn0030809	Length:	1824	Species:	Drosophila melanogaster
Sequence 2:	NP_011700.1	Gene:	UBR1 / 853096	SGDID:	S000003416	Length:	1950	Species:	Saccharomyces cerevisiae

Alignment Length:	2123	Identity:	434/2123 - (20%)
Similarity:	760/2123 - (35%)	Gaps:	696/2123 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GTLDRSDIIEFLKRESPKYFDYQTSATVKDTNVITL-------------KCMFKESLAKEEIIDV 82
            |..:|:|:...||....:|..:..|.:  ..|:.||             ..:|.:||  |:.:|:
Yeast    33 GPTERADMSRALKEFIYRYLYFVISNS--GENLPTLFNAHPKQKLSNPELTVFPDSL--EDAVDI 93

  Fly    83 -------------VVEFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLC 134
                         :.|..:||          :..:|...||:.||.|||.|.|.|||.|.|||||
Yeast    94 DKITSQQTIPFYKIDESRIGD----------VHKHTGRNCGRKFKIGEPLYRCHECGCDDTCVLC 148

  Fly   135 VNCFKRSAHRFHKY--KMSTSGGGGCCDCGDDEAWKKDQYCELHLANRKNPL-----------ES 186
            ::||....|..|..  .:.|....|.|||||:|||....:|:..  .::|.:           |.
Yeast   149 IHCFNPKDHVNHHVCTDICTEFTSGICDCGDEEAWNSPLHCKAE--EQENDISEDPATNADIKEE 211

  Fly   187 KILTDAV-LERVEICFGAILAFCVSYL--EIEPNASLQ--------------------------- 221
            .:..|:| :..||:....:..:.:...  .|||..::|
Yeast   212 DVWNDSVNIALVELVLAEVFDYFIDVFNQNIEPLPTIQKDITIKLREMTQQGKMYERAQFLNDLK 276

  Fly   222 -----CLDGNVEG--------------GQVDGAQYCTVLYNDESHTFDQVIQTLTKIAKCRAKDA 267
                 ..||....              .::|...|..::||||.|.:.|....|.:    ...|.
Yeast   277 YENDYMFDGTTTAKTSPSNSPEASPSLAKIDPENYTVIIYNDEYHNYSQATTALRQ----GVPDN 337

  Fly   268 MEI---VAAIDREGRAVVKCDT-----------------------------FEECNKLKVSIENQ 300
            :.|   .:.||.||||::||..                             .|.|..:.:.|.:.
Yeast   338 VHIDLLTSRIDGEGRAMLKCSQDLSSVLGGFFAVQTNGLSATLTSWSEYLHQETCKYIILWITHC 402

  Fly   301 MILP-TSLVSTARNNQSLRTSVLHIGAVACQQFA---------------------LQLLGWFQEF 343
            :.:| :|..:|.||.........::.|..|:...                     |.:|....:.
Yeast   403 LNIPNSSFQTTFRNMMGKTLCSEYLNATECRDMTPVVEKYFSNKFDKNDPYRYIDLSILADGNQI 467

  Fly   344 LVRHYLF-----RKTFSELV-------QRKQETFCIRHILEYDVKLWKTARTCWHRLLISGMLME 396
            .:.|:..     ..:.|.|:       .|......::|||.:|.:.||..|.....::|..:...
Yeast   468 PLGHHKILPESSTHSLSPLINDVETPTSRTYSNTRLQHILYFDNRYWKRLRKDIQNVIIPTLASS 532

  Fly   397 YDNKMILAQEFSRRYATIVEDF--------ISDDHDHAFSIVSLSVQLFTVPSIAHHLIAHEGIF 453
            ...|.|..|:       :||.|        ..|......:|....|||||.|:.|.::..::...
Yeast   533 NLYKPIFCQQ-------VVEIFNHITRSVAYMDREPQLTAIRECVVQLFTCPTNAKNIFENQSFL 590

  Fly   454 D---KLLHTFYH-------VAIEKFIRNKTLHFSKNIASLTFFKRANYILYDLRYLLS------- 501
            |   .::..|..       |.|.:.::...|..|.:|:    ||:.   ||.:..|||
Yeast   591 DIVWSIIDIFKEFCKVEGGVLIWQRVQKSNLTKSYSIS----FKQG---LYTVETLLSKVHDPNI 648

  Fly   502 -LKP-DVLSNDLRNGFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTIS 564
             |:| :::|             |:.:..:..|...:.|:.|:|:.:|.:   .|..:::..|:|.
Yeast   649 PLRPKEIIS-------------LLTLCKLFNGAWKIKRKEGEHVLHEDQ---NFISYLEYTTSIY 697

  Fly   565 QVIDWA------SGDVKLLRKLYKMTMRALVSNSFIVGGEKVMQPKKVAD-HVANCLVYDISVQP 622
            .:|..|      |.| .:..||:...:|  :.:||:  |.:.:..|.:.| |  ..:.:.:|.:.
Yeast   698 SIIQTAEKVSEKSKD-SIDSKLFLNAIR--IISSFL--GNRSLTYKLIYDSH--EVIKFSVSHER 755

  Fly   623 VSIHLPLSRFFAGIYLHLGAHDLTYDGLQTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRR 687
            |:...||....:.:...:...| .|:.|:..::.|  |::...:...|||     :|:..|.|.|
Yeast   756 VAFMNPLQTMLSFLIEKVSLKD-AYEALEDCSDFL--KISDFSLRSVVLC-----SQIDVGFWVR 812

  Fly   688 NGYTLLHQLYFYRNVRCRVEMLDRDIACLQIGASLMESNE---FLIHVLNRFNTIPWL--QENYW 747
            ||.::|||..:|:| ...:....|||...|: |.|.|.::   .:.::|:|:..:.|.  :.:|
Yeast   813 NGMSVLHQASYYKN-NPELGSYSRDIHLNQL-AILWERDDIPRIIYNILDRWELLDWFTGEVDY- 874

  Fly   748 SLLSGNEMNDDIIREASIFDEFLELLIVIIGER-WMPGVSMVTEE--DRLRKEIIQLLCIKPYSH 809
                .:.:.:|.|  :.|..:|:..:..|:.|| :....|.:.:.  |:::..||..|.:||.|:
Yeast   875 ----QHTVYEDKI--SFIIQQFIAFIYQILTERQYFKTFSSLKDRRMDQIKNSIIYNLYMKPLSY 933

  Fly   810 SELSRALPDGNSGNSDNVFEEVINTVAVFKKPVGADSKGVYELKEHL------LKEFNMYFYHYT 868
            |:|.|::||..:.::.. |:|.:..|:||.:|.|....||::||..|      ||..|:     .
Yeast   934 SKLLRSVPDYLTEDTTE-FDEALEEVSVFVEPKGLADNGVFKLKASLYAKVDPLKLLNL-----E 992

  Fly   869 KEDKSKAEELQRERRKAKKQL---VCCPPPMLPKLTP------AFT-------PMANILQ-C--- 913
            .|.:|.|..::....|.|.::   |..|...:.:|..      |||       .:..:|| |
Yeast   993 NEFESSATIIKSHLAKDKDEIAKVVLIPQVSIKQLDKDALNLGAFTRNTVFAKVVYKLLQVCLDM 1057

  Fly   914 --PVFLN------------------------------ICSLIMERALNAYSRSFTESHLQKVLHL 946
              ..|||                              ||:|::..| ||.|..|:||.::|..:|
Yeast  1058 EDSTFLNELLHLVHGIFRDDELINGKDSIPEAYLSKPICNLLLSIA-NAKSDVFSESIVRKADYL 1121

  Fly   947 LGYAIQEELSEHYPFL--SFYERSQEYGILEKLEELARCPRLEAHYDFVLWTIERFKQLQAKQAP 1009
            |...|.::.:|.:..|  ||   ..:|                         :..:|..:.:|
Yeast  1122 LEKMIMKKPNELFESLIASF---GNQY-------------------------VNDYKDKKLRQ-- 1156

  Fly  1010 SDGRAGPSCSQQGTGGKLSLSAEEQAREERENRARLAAERRAHIMAQMQKAQKSFISSNAEMFAD 1074
                              .::.:|   .|:|.:.|||.:.:|.::|:....|..|:..:...|.:
Yeast  1157 ------------------GVNLQE---TEKERKRRLAKKHQARLLAKFNNQQTKFMKEHESEFDE 1200

  Fly  1075 TENETR-----------------KESASTGPMDWEDIPPEEEQGAVALESKV-----------AC 1111
            .:|:..                 ::|:||   |:..||...:...:.....:           ..
Yeast  1201 QDNDVDMVGEKVYESEDFTCALCQDSSST---DFFVIPAYHDHSPIFRPGNIFNPNEFMPMWDGF 1262

  Fly  1112 LGPDRKFYHGTDDTFKCILCFENCAISRGGRQLVSSAFVQTSRVIFTTPNLRNSQSALHISCCGH 1176
            ...|.|..:..||..:.:....:|.                ||.:|.:              |.|
Yeast  1263 YNDDEKQAYIDDDVLEALKENGSCG----------------SRKVFVS--------------CNH 1297

  Fly  1177 VMHYSCWLEYFTNEEFKELRRPHRNRAALAQAANVEFQCPYCRTLSNAIIPVTETLPAFSAPPSP 1241
            .:|::|:..|...:.|               ::|. |.||.|:|.||..:|:.:|        |.
Yeast  1298 HIHHNCFKRYVQKKRF---------------SSNA-FICPLCQTFSNCTLPLCQT--------SK 1338

  Fly  1242 NESYLPLDSFVE---IMSTLAIELGNVKDHELTTLPSVSNILRLSGVVGGLAQFERSVQLIKNPP 1303
            ..:.|.||.|:|   .:.||:.......:....|:.|:.::: :|...|    |:::|
Yeast  1339 ANTGLSLDMFLESELSLDTLSRLFKPFTEENYRTINSIFSLM-ISQCQG----FDKAV------- 1391

  Fly  1304 RLHADYIEGIEFLKKALLNTMKIQQSHLKDHPAIESIEMVPILWDSCSYTLQALEIYLYAVEKPL 1368
            |..|::                   || ||...|.|:.     |   :.|:..||| ...:|||.
Yeast  1392 RKRANF-------------------SH-KDVSLILSVH-----W---ANTISMLEI-ASRLEKPY 1427

  Fly  1369 KAELSMRHQSCARNL--VRACSR-------SSALEWETDLPLLPPMRSQAEFSSRLLDTIFNQND 1424
            ........:...:.|  :..|..       ..::|:|       |...|.       ||::|||.
Yeast  1428 SISFFRSREQKYKTLKNILVCIMLFTFVIGKPSMEFE-------PYPQQP-------DTVWNQNQ 1478

  Fly  1425 TSVLEWDCFRVLVPFQFGVLN-LMVPEKGYKTIIPSGSMFDFYIMQTMFLAQLTKAVLCFDVEKE 1488
            .             ||:.|.: |..|....:|:..:.:.|....::. ||..|:.|.   .|.|.
Yeast  1479 L-------------FQYIVRSALFSPVSLRQTVTEALTTFSRQFLRD-FLQGLSDAE---QVTKL 1526

  Fly  1489 KAKRAE-----KAPNSELTQLDYI-----EQLPSR----------IRDNMIDFYRRYNIPARVLQ 1533
            .||.::     |.....|..|..|     |.|.|.          :..:::...||..:..:||.
Yeast  1527 YAKASKIGDVLKVSEQMLFALRTISDVRMEGLDSESIIYDLAYTFLLKSLLPTIRRCLVFIKVLH 1591

  Fly  1534 KTKQKQLVEEESEENQGHGQTVVIPCESHHLALLLEYVQRQMSSFLRCSCLFYRFLTDVDFPDT- 1597
                 :||::...|      |:||  ..|.:.                        .:::|.||
Yeast  1592 -----ELVKDSENE------TLVI--NGHEVE------------------------EELEFEDTA 1619

  Fly  1598 --------FPTDQPDRFDLMCQYLGLDPMLGVYFDMETVYATMMHSFASHPHIDREVEQRCQPDA 1654
                    ..|::....||:                     |...|..|||:::
Yeast  1620 EFVNKALKMITEKESLVDLL---------------------TTQESIVSHPYLE----------- 1652

  Fly  1655 RRSLQVEPCLRPLPRLKVLCDDFSDLINSV----SDIFCPNNEREEMKTP------TMCLICGLI 1709
              ::..|.|    ..:|::  |.|..:|:.    .:|.......:.||..      .:||.||:
Yeast  1653 --NIPYEYC----GIIKLI--DLSKYLNTYVTQSKEIKLREERSQHMKNADNRLDFKICLTCGV- 1708

  Fly  1710 LCGQSYCCQPELGKVSVGACTH----HAHA-CGAEVGIFLRIRDCQV-VYLGR-GKGCFVPPPYL 1767
                         ||.:.|..|    |.:. |....|.||.....:| ::|.: ....|:..|||
Yeast  1709 -------------KVHLRADRHEMTKHLNKNCFKPFGAFLMPNSSEVCLHLTQPPSNIFISAPYL 1760

  Fly  1768 DEYGETDM-GLRRGNPLRLSQAAYRKIYLQWLGHGLHGEIARL 1809
            :.:||... .:|||:...|:...|..:...|:.:.:.|.|:|:
Yeast  1761 NSHGEVGRNAMRRGDLTTLNLKRYEHLNRLWINNEIPGYISRV 1803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubr1	NP_001245723.1	zf-UBR	109..176	CDD:280386	33/68 (49%)
Ubr1	NP_001245723.1	ClpS	236..301	CDD:280736	21/96 (22%)
UBR1	NP_011700.1	ZnF_UBR1	121..193	CDD:197698	33/73 (45%)
		ClpS	308..>358	CDD:412656	17/53 (32%)
		RING_Ubox	1286..1332	CDD:418438	18/91 (20%)
		RING-H2 finger (C3H2C3-type)	1286..1323	CDD:319361	14/82 (17%)
		PRT6_C	1402..1793	CDD:408765	101/521 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344452
Domainoid	1	1.000	136	1.000	Domainoid score	I1070
eggNOG	1	0.900	-	-		E1_KOG1140
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I760
Isobase	1	0.950	-	0	Normalized mean entropy	S5556
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001341
OrthoInspector	1	1.000	-	-		otm46870
orthoMCL	1	0.900	-	-		OOG6_101603
Panther	1	1.100	-	-	O	PTHR21497
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1593
SonicParanoid	1	1.000	-	-		X1260
TreeFam	1	0.960	-	-
	13	12.730