DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ubr1 and UBR2

DIOPT Version :9

Sequence 1:NP_001245723.1 Gene:Ubr1 / 32687 FlyBaseID:FBgn0030809 Length:1824 Species:Drosophila melanogaster
Sequence 2:NP_013124.1 Gene:UBR2 / 850711 SGDID:S000004014 Length:1872 Species:Saccharomyces cerevisiae


Alignment Length:2107 Identity:413/2107 - (19%)
Similarity:740/2107 - (35%) Gaps:555/2107 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 LDRSDIIEFLKRESPKYFDYQTSATVKDTNVITLKCMFK-----------------ESLAKEEII 80
            |..::|.:|| .|.||....:.|.|.......||....|                 |:...|:..
Yeast     6 LSITNIRDFL-TELPKLAKCEYSETTSYLLWKTLNLRLKHSDNDINWRSLVSILNSEAWENEKYR 69

  Fly    81 DVV-------VEFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNCF 138
            |::       :||   :|...::..:.:    .|.|.::....|..|.|..|..:|...:|..||
Yeast    70 DILNGRKWRTLEF---ENDHHSVGNMHI----GTACTRLCFPSETIYYCFTCSTNPLYEICELCF 127

  Fly   139 KRSAHRFHKY--KMSTSGGGGCCDCGDDEAWK--KDQY-CELHLANRKNPLESKILTD--AVLER 196
            .:..|..|.|  |:.....|..|.|||..|:.  .|.: |:..|.|.....::..:||  .|:..
Yeast   128 DKEKHVNHSYVAKVVMRPEGRICHCGDPFAFNDPSDAFKCKNELNNIPISNDNSNVTDDENVISL 192

  Fly   197 VEICFGAILAFCVSYLE--------------IEPNASLQCLDGNVEGGQVDGAQYCTVLYNDESH 247
            :......::...|||.|              :.||.: ...|..:|..:      |..|.|||:.
Yeast   193 LNYVLDFLIDVTVSYKEEAEAHSSERKASSLMHPNQN-SITDDIMEKHE------CEPLVNDENF 250

  Fly   248 TF--------------DQVIQ---------------TLTKIAKCRAKDAMEIVAAID--REGRAV 281
            .|              :..||               |:|:|.....:.|:.|..|::  .:...|
Yeast   251 VFFDNNWSNTRKEAHMEWAIQIEEEECNVHYMDLASTITRILNTPVEYAISITKALEDSHDVVTV 315

  Fly   282 VKCDTFEECNKLKVSIENQMIL-----------------------------PTSLVSTARNNQSL 317
            ::.:.|.|.:::....:.:.|:                             .|||    :|..:|
Yeast   316 LQSENFFEIDQIAKEFQKENIVVHVRKADDIFKRKLTDDLTDWLYSLCFKAATSL----QNKYAL 376

  Fly   318 RTSVL-----HIGAVACQ------QFA-LQLLG------------WFQEFLVRHYLFRK------ 352
            |.|:|     |...:...      .|: :.|||            ||:.:.:.:....:      
Yeast   377 RISMLDVWYSHFSKMRVSPTNTNPDFSKINLLGGFLISNEDSDESWFKPWSLENIEDERISKILT 441

  Fly   353 TFSELVQRKQETFCIRHI-------LEYDV-----KLWKTARTCWHRLLISGMLMEYDNKMILAQ 405
            .::|.:.|......:.|.       .:|.:     .|.|.::....:::.|...:..:::..||.
Yeast   442 NYNERLIRAHSPNTVSHFYNFYGSRFQYIIINSINILSKKSKFKMLKIMASLFSLRDESRKFLAA 506

  Fly   406 EFSRRYATIVEDFI-SDDHDHAFSIVSLSVQ-LFTVPSIAHHLIAHEGIFDKLLHTFY------- 461
            ::...|.:::.|.: ||..:...:::|:..| .|..||||:..|: .|..::.:...:       
Yeast   507 QYIDVYLSVLYDAVASDAKECQVTLMSILGQYTFQDPSIANMTIS-SGFIERTIRFAFTLMAFNP 570

  Fly   462 -----HVAIEKF----IRNKTLHFSKNIASLTFFKRANYILYDLRYLLS---LKPDVLSND-LRN 513
                 ::.|..:    :..:|:   :|..::..||       ||..::|   :..::|||: :.|
Yeast   571 EDLMSYLPISLYNGFKLPTETI---RNRRTIICFK-------DLCTIMSANTVPEELLSNEAIFN 625

  Fly   514 GFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNL---HIKLAT-----TISQVIDWA 570
            ..:|.......||       .:.|:|.:|::.|.....||..   .|.:.|     :||.|.|.|
Yeast   626 AIIESFSEFSNVL-------PLKRETKEHVEVENFDFSAFYFFFSSILIMTDGYTRSISLVKDAA 683

  Fly   571 SGDVKLLRKLYKMTMRALVSNSFIVGGEKVMQP-------------------KKVADHVANCLVY 616
            .....:|:.|.....|...|   :....|.:.|                   :.:.::||..:.:
Yeast   684 FRKQIVLKLLDVAQTREFES---LTNSRKAISPDNASTNENDSNKATLSTVRETICNYVAETINF 745

  Fly   617 DISVQPVSIHLPLSRFF--------AGIYLHLGAHDLTYDGL----QTETEALSIKLTPREIIEP 669
            .:.|.......|:|..|        .|.|..:.|....|..|    |.:.:||.|.       |.
Yeast   746 QVGVNTQYFFNPMSYLFKFVIQWSQCGRYEPIPASLTNYINLFEVFQDKQKALYIS-------ES 803

  Fly   670 VLCTQAMIAQVGAGLWRRNGYTLLHQLYFYRNVRCRVEMLDRDIACLQIGASLMESNEFLIHVLN 734
            .|.|..:|.|:..|.|.|||..:.||...|.....|......||..:|...::...:|.::..|:
Yeast   804 ALSTLVLIGQINVGFWVRNGTPITHQARMYTKYSMREFTYISDIFNVQFSMAMCNPDELMVTYLS 868

  Fly   735 RFNTIPWLQENYWSLLSGNEMND--DIIREASIFDEFLELLIVIIGE-RWMPGVSMVTE------ 790
            |:....|        .:|..|.|  |.....::.:|.:.|||.::.| |     |:|.:      
Yeast   869 RWGLKHW--------ANGVPMYDYPDTETTVAVVNECILLLIQLLTEVR-----SLVMKSSKEGF 920

  Fly   791 EDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSDNVFEEVINTVAVFKKPVGADSKGVYELKEH 855
            |...:.|||..||....|::::...:|:..:.:..  |:..:...|.:..||.....|::.|||.
Yeast   921 ERTFKSEIIHALCFDTCSYAQIVNCIPEHITKHPS--FDIYLEKYANYTSPVSLTDNGIFVLKEK 983

  Fly   856 LLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQLVCCPPPMLPKLTPAFTP---MANILQCPVF- 916
            ...|.:.|:...:...:...|:..|......|::         |....|.|   :.::|:..:| 
Yeast   984 YKDEIDPYYIGLSSSRRYDVEKNIRLNMANLKKM---------KYEDTFVPAKKVKDLLKNTLFS 1039

  Fly   917 -------LNICSLIMERALNAYSRSFTESHLQKVLHLLGYAIQEELSEHYPFLSFYERSQEYGIL 974
                   :|...|.::..|:...:...::.|.:|:||:...:...|:|....|     ..||.|:
Yeast  1040 GLYSISSVNTFGLFLKNTLDHIIKYDYDNLLPRVVHLIHLCVVNNLNEFMGIL-----WHEYAIV 1099

  Fly   975 EKLEELARCPRLEAHYDFVLWTIERFKQLQAKQAPSDGR----------AGPSCSQQG------- 1022
            :  .|.       .||..: .:|..:..|:...:.|.|:          ..|..:...       
Yeast  1100 D--TEF-------CHYHSI-GSILYYCLLKDNFSESHGKIREIFRYLMETAPHVNVNSYLREQTT 1154

  Fly  1023 --TGGKLSLSAEEQAREER--ENRARLAAERRAHIMAQMQKAQKSFISSNAEMFADTE--NETRK 1081
              |.|.|..:.|:::.:::  |.:..||..|:..:|.::.:.|..|:.:|:   .||.  :..|.
Yeast  1155 SYTPGILWPTKEDKSHKDKEFERKKHLARLRKKKLMKKLAQQQMKFMENNS---VDTSDISTPRT 1216

  Fly  1082 ESASTGPMDWEDIPPEEEQGAV---ALESKVACLGP--DRKFY-----------HGTDDTFKCIL 1130
            .|.|..|   ..|..|.....:   ..:..|.|..|  |..|.           ||.|.|....:
Yeast  1217 TSPSLSP---TRINAENSSNTINSCCDDDCVFCKMPKDDDVFVYFSYQERNICDHGIDFTNPTDV 1278

  Fly  1131 CFENCAISRGGRQLVSSAFVQT------SRVIFTT--PNLRNSQSALHISCCGHVMHYSCWLEYF 1187
            ...|...|  |:|...||..:.      :|:.||:  |.||         .|||..|..|...:.
Yeast  1279 NRINSLFS--GKQTKDSAIQENPQDDDGTRLKFTSCEPVLR---------ACGHGSHTKCLSGHM 1332

  Fly  1188 TNEEFKELRRPHRNRAALAQAANVEFQCPYCRTLSNAIIPVTETLPA------FSAPPSPNESYL 1246
              :..:.::........|:..:.:.: ||.|.:|||:.:|.|..:..      |......:|:..
Yeast  1333 --KSIRGIQNQTTKNIPLSYGSGLIY-CPVCNSLSNSFLPKTNDIDKRTSSQFFMCIEKRSEAEE 1394

  Fly  1247 PLDSFVEIMSTLAIELGNVKDHELTTLPSVSNILRLSGVVGGLAQFERSVQLIKNPPRLHADYIE 1311
            .||....|....|:.||:::..::||:.                                    :
Yeast  1395 NLDPMSSICIKAAMILGDLQGKKVTTIE------------------------------------D 1423

  Fly  1312 GIEFLKKALLNTMKIQQSHLKDHPAIESIEMVPILWDSCSYTLQ---ALEIYLY---AVEKPLKA 1370
            ..:.:....:||:...:..|:.|.....|..:..:...|..||.   .|:.::|   ...|...:
Yeast  1424 AYKVVNSVFINTISNTELRLRSHKKEGKIVNMERISSQCILTLHLVCELKSFIYKKFVNSKTFSS 1488

  Fly  1371 ELSMRHQSCARNLVRACSRSSALEWETDL--------PLLPPMRSQAEFSSRLLDTIFNQNDTSV 1427
            |:|.:..:....|::..:.:..|....:.        |..|.:.....|..|....:.      :
Yeast  1489 EISRKIWNWNEFLIKGNNVNLLLYMSQNFDNIDGGKTPQPPNLCIYEMFKRRFHQLLL------L 1547

  Fly  1428 LEWDCFRVLVPFQFGVLN-LMVPEKGYKTIIPSGSMFDFYIMQTMFLAQLTKAVLCFDVEKEKAK 1491
            |..|..|  |.|.....| :.:...|.:.  ||.|.  .|:..|     ..|.|..|..:..:  
Yeast  1548 LARDMMR--VNFYKDCRNKIKISSNGSEE--PSTSF--SYLFNT-----FKKYVDLFKPDDVR-- 1599

  Fly  1492 RAEKAPNSELTQLDYIEQ-LPSRIRDNMIDFYRR----YNIPARVLQKTKQKQLVEEESEENQGH 1551
                   .:.|.|:.|:. :.|.:.:::..|.||    :||           |..::...:|..:
Yeast  1600 -------FDFTSLEKIKDFICSLLLESLSIFCRRTFLLFNI-----------QYDDDGDGDNNNN 1646

  Fly  1552 GQTVVIPCESHHLALLLEYVQ-RQMSSFLRCSCLFYRFLTD-----VDFPDTFPTDQPDRFDLMC 1610
            .....:..:...:.|:..|.: ..::.||:  ..||..||.     .|..|.....|        
Yeast  1647 RSNNFMDVKQREIELIFRYFKLPNLTHFLK--DFFYNELTQNIERYNDGNDNLRIQQ-------- 1701

  Fly  1611 QYLGLDPMLGVYFDMETVYATMMHSFASHPHIDREVEQRCQPDARRSLQVEPCLRPLPRLKVLCD 1675
                      |.:||.                 :.:..|..|.......:|   .||...|...|
Yeast  1702 ----------VIYDMV-----------------QNINTRAYPSPEHIQLIE---LPLNLSKFSLD 1736

  Fly  1676 DFSDLINSVSDIFCPNNEREEMKTPTMCLICGLILCGQSYCCQPELGKVSV--GACTHHAHACGA 1738
              :|.|::..|       :.|:   .:||     ||||....|..:.....  |.||.|... |.
Yeast  1737 --NDEISNKCD-------KYEI---AVCL-----LCGQKCHIQKSIALQGYLQGECTDHMRN-GC 1783

  Fly  1739 EV----GIFLRIRDCQVVYLGRGK-GCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWL 1798
            |:    |:|| :.....:||..|| |.|...|||.:||||:...:.|.|:.|::|.|..:..:.:
Yeast  1784 EITSAYGVFL-MTGTNAIYLSYGKRGTFYAAPYLSKYGETNEDYKFGTPVYLNRARYANLANEIV 1847

  Fly  1799 -GHGLHGEIARLNDNANVAAAAQWHHM 1824
             |:.:...:.||.|.:  |....|..|
Yeast  1848 FGNMIPHIVFRLTDGS--ADLGGWETM 1872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ubr1NP_001245723.1 zf-UBR 109..176 CDD:280386 21/71 (30%)
ClpS 236..301 CDD:280736 17/95 (18%)
UBR2NP_013124.1 ZnF_UBR1 96..171 CDD:197698 22/74 (30%)
RING_Ubox 1314..1369 CDD:418438 15/66 (23%)
PRT6_C 1434..1842 CDD:408765 104/503 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157344454
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1140
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG59210
OrthoFinder 1 1.000 - - FOG0001341
OrthoInspector 1 1.000 - - otm46870
orthoMCL 1 0.900 - - OOG6_101603
Panther 1 1.100 - - LDO PTHR21497
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
98.710

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