Protein Alignment Ubr1 and Ubr3

DIOPT Version :10

• Sequence 1: NP_573184.1
• Gene: Ubr1 / 32687
• FlyBaseID: FBgn0030809
• Length: 1824
• Species: Drosophila melanogaster
• Sequence 2: XP_036018419.1
• Gene: Ubr3 / 68795
• MGIID: 1861100
• Length: 1904
• Species: Mus musculus
• Alignment Length: 2078
• Identity: 424/2078 - (20%)
• Similarity: 719/2078 - (34%)
• Gaps: 639/2078 - (30%)

  Fly    89 GDNPSSALE--KLRLEG--------------NTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNC 137
            |:....|||  |..|.|              :.|.:||.|:......|.||.||:.|...||..|
Mouse    84 GEAEEDALEWCKCLLAGGGGYEEFCAAVRAYDPAALCGLVWTANFVAYRCRTCGISPCMSLCAEC 148

  Fly   138 FKRSAHRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELH-LANRKN----PLESKILTDAVLERV 197
            |.:..|..|.:.|..|..||.|||||....::..:|..| :.:..|    |.:..::::.||.|.
Mouse   149 FHQGDHTGHDFNMFRSQAGGACDCGDSNVMRESGFCRRHQIKSSSNIPCVPKDLLMMSEFVLPRF 213

  Fly   198 EICFGAILAFCVSYL-------------EIEPNASLQCLDGNVE--------GGQVDGAQYCTVL 241
            ..|.       :.||             |.:.|..||.|:..:.        ||.:... ...||
Mouse   214 IFCL-------IQYLREGYNEPAADAPSEKDLNKVLQLLEPQISFLEDLTKMGGAMRSV-LTQVL 270

  Fly   242 YNDESHTFDQVIQTLTKIAKCRAKDAMEIVAAIDREGRAVVKCDTFEECNKLKVSIENQMILPTS 306
            .|.::  :..:...|.:.| |..|...:.:.|:...|.      |:.| :||...::......::
Mouse   271 TNQQN--YKDLTAGLGENA-CAKKSHEKYLIALKSSGL------TYPE-DKLVYGVQEPAAGTST 325

  Fly   307 L------------------------------------VSTARNNQSLRTSVLHIGAVACQQFALQ 335
            |                                    :|:...:||:...:.|      :.|..:
Mouse   326 LAAQGFAGATGTLGQIDSSDEEDQDGSQGLGKRKRVKLSSGTKDQSIMDVLKH------KSFLEE 384

  Fly   336 LLGWFQEFLVRHYLFRKTFSELVQRKQETFCIRHILEYDVKLWKTARTCWHRLLISGMLMEYDNK 400
            ||.|             |......:|..||.:                        .||.:.:.|
Mouse   385 LLFW-------------TIKYEFPQKMVTFLL------------------------NMLPDQEYK 412

  Fly   401 MILAQEFSRRYATIVEDFISDDHDHAFS--IVSLSVQLFTVPSIAHHLIAHEGIFDKLLHTFYHV 463
            :...:.|.:.||.|::...........|  ||.:|||||:...:|..:.....:.|.::....::
Mouse   413 VAFTKTFVQHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYM 477

  Fly   464 AIEKFIRNK------TLHFSKNIASLTFFKRANY--ILYDLRYLLSLKPDVLSNDLRNGFLEGCR 520
            .....|:::      :||...|... ...|...|  ::.|...:||      ...:...|||...
Mouse   478 MESCLIKSELQDEENSLHVVVNCGE-ALLKNNTYWPLVSDFINILS------HQSVAQRFLEDHG 535

  Fly   521 AL---MRVLNVMQGMESMTRQTGQHMDYEPE-WECAFNLHIKLATTISQVIDWASGDVKLLRKLY 581
            .|   |..::..|||....|:..:|:::|.: :..||...::...
Mouse   536 LLVTWMNFVSFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACA-------------------- 580

  Fly   582 KMTMRALVSNSFIVGGEKVMQPKKVADHVAN-CL------------VYDISVQPVSIHLPLSRFF 633
             ..|..|:|:.      ||.:.::...:|.. ||            |.:.:...|:.||||.|::
Mouse   581 -QPMWGLLSHC------KVRETQEYTRNVVRYCLEALQDWFDAINFVDEPAPNQVTFHLPLHRYY 638

  Fly   634 AGIYLH--LGAHDLTYDGLQTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNGYTLLHQL 696
            | ::|.  :...:|..|.|..:.|.| :||    :|.| |..||.:|::.:.:|.|||..:..|.
Mouse   639 A-MFLSKAVKCQELDLDSLLPDQEML-MKL----MIHP-LQIQASLAEIHSNMWVRNGLQIKGQA 696

  Fly   697 YFYRNVRCRVEMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLS-GNEMNDDII 760
            ..|........|:|.||..||:.||.::.:.|:..|..||..:..|     ::.| .:.|..|:.
Mouse   697 MTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLL-----TMASQHHNMVLDVE 756

  Fly   761 REASIFDEFLELLIVIIGERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSD 825
            .|.|:.:..|..|::::..|...|:|   ::|.||.|::..||:...:||.|...:|:..:..|.
Mouse   757 HERSMLEGALTFLVILLSLRLHLGMS---DDDILRAEMVAQLCMNDRTHSSLLDLIPENPNPKSG 818

  Fly   826 NV-----FEEVINTVAVFKKPV----GADSKGVYELKEHLL-KEFN--------MYFYHYTKEDK 872
            .:     ||.|::.||.|:.|:    |:..:|:|..|..:. :||:        :|     :.|.
Mouse   819 IIPGSYSFESVLSAVADFRAPIFEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVY-----RRDV 878

  Fly   873 SKAEELQRERRKAKKQLVCCPPPMLPKLT---PAFTPMANILQCP-----VFLNICSLIMERALN 929
            ..|.:......|...:....|.|...|.|   |::..:..:|.|.     :|..:..::|:.
Mouse   879 QSAMDRYTAFLKQSGKFPGNPWPPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDH--- 940

  Fly   930 AYSRSFTESHLQKVLHLLGYAI--------QEELSEHYP-------------------FLSFYER 967
               ::.:|..|..||:|:...:        :||:|...|                   |:: |.|
Mouse   941 ---QNLSEHVLCMVLYLIELGLENSADDDSEEEVSMGGPERCHDSWFPGSNLVSNMRHFIN-YVR 1001

  Fly   968 SQEYGILEKLEELARCPRLEAHYD------------------------FVLWTIERFKQLQ---- 1004
            .:   :.|...||.|.|......|                        |.| ..||.|:.|
Mouse  1002 VR---VPETAPELKRDPLASTSSDALDSLQNSRRPKVLQRENSGTAQVFSL-VAERRKKFQEIIN 1062

  Fly  1005 -----AKQA-----PSDGRAGPSCSQQGTGG-----------------KLS-------------- 1028
                 |.|.     ||...| |..|.|.|..                 |||
Mouse  1063 RSNSEANQVVRPKIPSKWSA-PGSSPQLTTAILEIKESILSLLIKLHHKLSGKQNSYYPPWLDDI 1126

  Fly  1029 -----------------------------------------------------LSAEEQAREERE 1040
                                                                 ::|.|:...::|
Mouse  1127 EVLIQPEIPKYNHGDGITAVERILLKAAVQSRMNKRIIEEICRKVTPPVPPKKITAAEKKTLDKE 1191

  Fly  1041 NRARLAAERRAHIMAQMQKAQKSFISSNAEMFADT-ENETRKESASTGPMDWEDI---------- 1094
            .|.:.|.||:..::|:....||||:.:  .|..|: ||:...|..:..|...|.:
Mouse  1192 ERRQKARERQQKLLAEFASRQKSFMET--AMDVDSPENDIPMEITTAEPQVSEAVYDCVICGQSG 1254

  Fly  1095 PPEEEQ--GAVALESKVACLGPDR------KFYHGTDDTFKCILCFENCAISRGGR-QLVSSAFV 1150
            |..|::  |.|.|....:.||..|      |.....::.   |..::.||.....| .|:...|.
Mouse  1255 PSSEDRPTGLVVLLQASSVLGQCRDNAEPKKLPIAEEEQ---IYPWDTCAAVHDVRLSLLQRYFK 1316

  Fly  1151 QTSRVIFTTPNLRNSQSALHISCCGHVMHYSC---WLEYFTNEEFKELRRPHRNRAALAQAANV- 1211
            .:|.::..:...   :..:::..|||.:|..|   ::|...|::             :.|..:|
Mouse  1317 DSSCLLAVSIGW---EGGVYVQTCGHTLHIDCHKSYMESLRNDQ-------------VLQGFSVD 1365

  Fly  1212 --EFQCPYCRTLSNAIIPVTETLPAFSAPPSPNESYL---PLDSFVEIMSTLAIELGNVKDHELT 1271
              ||.||.||..:|:::|        ..|.|..|:.|   |.:.                    :
Mouse  1366 KGEFTCPLCRQFANSVLP--------CYPGSNVENNLWQRPCNK--------------------S 1402

  Fly  1272 TLPSVSNILRLSGVVGGLAQFERSVQLIKNPPRLHADYIEGIEFLKKALLNTMKIQQSHLKDHPA 1336
            |...:..:..|.|..|.   |..|:....|       ..:.:|.:.|.:.||.:.:.......|.
Mouse  1403 TQDLIKEVEELQGRPGA---FPVSISSETN-------LSKEMESVMKDIKNTTQKKYRDYSKTPG 1457

  Fly  1337 IESIEMVPILWDSCSYTLQALEIYLYAVEKPLKAELSMRH---------------QSCARNLVRA 1386
            ....|.                :::|:|.: ...||.:.|               :||...|...
Mouse  1458 SPDNEF----------------LFMYSVAR-TNLELELIHRGGSLCSGGPSTAGKRSCLNQLFHV 1505

  Fly  1387 CSRSSAL--------EWETDLPLLPPMRSQAEFSSRLLDTIFNQNDTSVLEWDCFRVLVPFQFGV 1443
            .:....|        .|:....|:..|.||.....:       |.:..:|..|...:|:     :
Mouse  1506 LALHMRLYTIDSEYNPWKKLTQLVEDMNSQVGNEDQ-------QPEVPILYHDVTSLLL-----I 1558

  Fly  1444 LNLMVPE---KGYKTIIPSGSMFDFYIMQTMFLAQLTKAVLCFDVE-KEKAKRAEKAPNSELTQL 1504
            ..||:|:   |.:.|.          |::.:|....|:|:....|: .|:.:.|.|...:
Mouse  1559 QILMMPQPLRKEHFTC----------IVKVLFTLLYTQALAALSVKGTEEDRSAWKHAGA----- 1608

  Fly  1505 DYIEQLPSRIRDNMIDFYRRYNI-PARVLQKTKQKQLVEEESEENQGHGQTVVIPCESHHLALLL 1568
                     :|.:..|..:.|.: .:.|:.:..:.:|..||..:.......:....||     :.
Mouse  1609 ---------LRKDTCDAEKCYEVLLSFVISELSKGKLYYEEGAQECAMVSPIAWSPES-----ME 1659

  Fly  1569 EYVQRQMSSFLRCSCLFYRFLTDVDFPDTFPTDQPDRFDLMCQYLGLDPMLGVYFDMETVYATMM 1633
            .|:|.....|||.|.|....|...|.|.   ..:.:.|.::...|||.|         |.|.|
Mouse  1660 RYIQDFCLPFLRVSSLLQHHLFGEDLPS---CQEEEEFSVLASCLGLLP---------TFYQT-- 1710

  Fly  1634 HSFASHPHIDRE-----------VEQRC---------QPDARRSLQVEPCLRPLPRLKVLCDDFS 1678
                .||.|...           :.|.|         ..:..::|.::.....||.|..|.::::
Mouse  1711 ----DHPFISASCLDWPVAAFDIITQWCFEITSFTERHAEQGKALLIQESRWKLPHLLQLPENYN 1771

  Fly  1679 DLINSVSDIFC------PNNEREEMKTPTMCLICGLILCGQSYCCQPELGKVSVGACTHHAHACG 1737
            .:........|      |       |.|.:||:||..:|.:..||:.:    |...|..|:..||
Mouse  1772 TIFQYYHRKTCSVCTKVP-------KDPAVCLVCGTFVCLKGLCCKQQ----SYCECVLHSQNCG 1825

  Fly  1738 AEVGIFLRIRDCQVVYLGRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWLGH 1800
            |..||||.|....::.:...:.|.....|||.:||.|..||||.||.:.:..||.:..||:.|
Mouse  1826 AGTGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYICEERYRVLEQQWVSH 1888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr1	NP_573184.1	UBR-box_UBR1_like	108..176	CDD:439070	25/67 (37%)
		ClpS	236..301	CDD:460621	13/64 (20%)
		RING-H2_UBR1-like	1166..1227	CDD:438145	16/66 (24%)
		PRT6_C	1345..1799	CDD:465944	107/507 (21%)
Ubr3	XP_036018419.1	UBR-box_UBR3	120..188	CDD:439071	25/67 (37%)
		RING-H2_UBR3	1331..1383	CDD:438146	16/64 (25%)
		PRT6_C	1441..1887	CDD:465944	111/532 (21%)