DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ubr1 and Ubr2

DIOPT Version :9

Sequence 1:	NP_001245723.1	Gene:	Ubr1 / 32687	FlyBaseID:	FBgn0030809	Length:	1824	Species:	Drosophila melanogaster
Sequence 2:	XP_038939742.1	Gene:	Ubr2 / 363188	RGDID:	1593237	Length:	1764	Species:	Rattus norvegicus

Alignment Length:	1897	Identity:	622/1897 - (32%)
Similarity:	934/1897 - (49%)	Gaps:	238/1897 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ECSSP--LKEWRLKRQAGTLDRSDIIEFLKRESPKYFDYQTSATVKDTNVITLKCMFKESLAKEE 78
            |||:.  ..:|   .||..|.| ::.:.|....||.:       .:..|....|   :::||:..
  Rat    18 ECSAEEIAGKW---LQATDLTR-EVYQHLAHCVPKIY-------CRGPNPFPQK---EDTLAQHI 68

  Fly    79 IIDVVVEFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNCFKRSAH 143
            ::..:..::.|::|:....||......:.:||:|||.||||||||:|.||||||||:.||..|.|
  Rat    69 LLGPMEWYICGEDPALGFPKLEQANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMQCFLGSIH 133

  Fly   144 RFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELH------LANRKNPLESKILTDAVLERVEICFG 202
            |.|:|:|:||||||.|||||.||||:..||:.|      :...::||..  |::.|:.|....|.
  Rat   134 RDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQRHELSSSEVVEEEDPLVH--LSEDVIARTYNIFA 196

  Fly   203 AILAFCVSYLEIEPNASLQCLDGNVEGGQVDGAQYCTVLYNDESHTFDQVIQTLTKIAKCRAKDA 267
            .:..:.|..|..|..:.   |..::|.|:.....|| :|:|||.||::|||.||.|...|..|:|
  Rat   197 IMFRYAVDMLTWEKESE---LPEDLEVGEKTDTYYC-MLFNDEVHTYEQVIYTLQKAVNCTQKEA 257

  Fly   268 MEIVAAIDREGRAVVKCDTFEECNKLKVSIENQMILPTSLVSTARNNQSLRTSVLHIGAVACQQF 332
            :.....:||:||..|:...|:.|::.|..|         :.:|:|..:.|:..|:|....|.|.|
  Rat   258 IGFATTVDRDGRRSVRYGDFQYCDQAKTVI---------VRNTSRQTKPLKVQVMHSSVAAHQNF 313

  Fly   333 ALQLLGWFQEFL-----VRHYLFRKTFSELVQRKQETFCIRHILEYDVKLWKTARTCWHRLLISG 392
            .|:.|.|....:     :|..|.:....|....:..:...|.:|. |.||||.||:.:|:|.:|.
  Rat   314 GLKALSWLGSVIGYSDGLRRILCQVGLQEGPDGENSSLVDRLMLN-DSKLWKGARSVYHQLFMSS 377

  Fly   393 MLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAHHLIAHEGIFDKLL 457
            :||:...|.:.|..|::.|..:..||:.|||:.|.|:.:||||.||.|::|..||..|.:...::
  Rat   378 LLMDLKYKKLFAVRFAKNYRQLQRDFMEDDHERAVSVTALSVQFFTAPTLARMLITEENLMTVII 442

  Fly   458 HTFYHVAIEKFIRNKTLHFSKNIASLTF-FKRANYILYDLRYLLSLKPDVLSNDLRNGFLEGCRA 521
            ..|......:..:.: ..|.:..|...| |:|...::.||:|:|..||...|::||..||:|..|
  Rat   443 KAFMDHLKHRDAQGR-FQFERYTALQAFKFRRVQSLILDLKYVLISKPTEWSDELRQKFLQGFDA 506

  Fly   522 LMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDWASGDVKLLRKLYKMTMR 586
            .:.:|..||||:.:|||.|||::.|||||.||.|.:||...||.|.||.:.|.|:|.:.||..:.
  Rat   507 FLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMVQDWCALDEKVLIEAYKKCLA 571

  Fly   587 ALVS-NSFIVGGEKVMQP--KKVADHVANCLVYDISVQPVSIHLPLSRFFAGIYLHLGAHDLTYD 648
            .|:. :.....||   ||  ..:..|....:.|.:|.:.||||||:||..||:::.|...::.|.
  Rat   572 VLMQCHGGFTDGE---QPITLSICGHSVETIRYCVSQEKVSIHLPISRLLAGLHVLLSKSEVAYK 633

  Fly   649 GLQTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNGYTLLHQLYFYRNVRCRVEMLDRDI 713
              ..|...|| :|:|..:||..|....:.|||.||:|||||::|::|:|:|.||:||.||.|:||
  Rat   634 --FPELLPLS-ELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDI 695

  Fly   714 ACLQIGASLMESNEFLIHVLNRFNTIP-WLQENYWSLLSGNEMNDDIIRE-ASIFDEFLELLIVI 776
            ..||.|.|:|:.|.||:.:|:||.... :...:|....|....:.|:::: .::.:|.|.|:|::
  Rat   696 VMLQTGVSMMDPNHFLMIMLSRFELYQIFSTPDYGKRFSSEVTHKDVVQQNNTLIEEMLYLIIML 760

  Fly   777 IGERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSDNVFEEVINTVAVFKKP 841
            :|||:.|||..|...|.:::|||..|.|||.:||||.::||:..  |.:...|.||.|||.||||
  Rat   761 VGERFSPGVGQVGATDEIKREIIHQLSIKPMAHSELVKSLPEDE--NKETGMESVIETVAHFKKP 823

  Fly   842 VGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQLVCCPPPMLPKLTPAFTP 906
             |...:|:||||....||||:||||:::.::|||||.||:.::..|:....|||.||...|.|..
  Rat   824 -GLTGRGMYELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRENKEDTALPPPALPPFCPLFGS 887

  Fly   907 MANILQCPVFLNICSLIMERALNAYSRSFTESHLQK----VLHLLGYAIQEE-------LSEHYP 960
            :.|||||.|.|:|...|::.|:..:..:::||.||:    ||||:|.|:|||       :..|..
  Rat   888 LVNILQCDVMLSIMGTILQWAVERHGSAWSESMLQRFLLEVLHLIGMALQEEKHHLENAVEGHVQ 952

  Fly   961 FLSFYERSQEYG--------ILEKLEELARCPRLEAHYDFVLWTIERFKQLQAKQAPSDGRAGPS 1017
            ..:|.::..:.|        ||..||.|...|.||.|.|.:.|.::.|..:  |:......:.|.
  Rat   953 TFTFTQKISKPGDAPNNSPSILAMLETLQNAPSLEVHKDMIRWLLKMFNTI--KKIRESSSSSPV 1015

  Fly  1018 CSQQGTGGKLSL---SAEEQAREERENRARLAAERRAHIMAQMQKAQKSFISSNAEMFADTENET 1079
            ...:|...:..:   |:.::.:.||:.:|.:|..||..|||||.:.|:.||..|.|:|..|   .
  Rat  1016 AEAEGAIMEEVIENKSSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQT---I 1077

  Fly  1080 RKESASTGPMDWEDIPPEEEQGAVALESKVACLGPDRKFYHGTDDTFKCILCFENCAISRGGRQL 1144
            ..:::::..:|...:.|         ::.:..|||.:...........||||.|...::...|.:
  Rat  1078 ELDASASAALDNSPLVP---------DAALTALGPAQTQVPEPRQFVTCILCQEEQEVTVESRAM 1133

  Fly  1145 VSSAFVQTSRV-----------------IFTTPNLRNSQSALHISCCGHVMHYSCWLEYFTNEEF 1192
            |.:||||.|.|                 :|..|:|   ....|...|||.||..||..||.:.:.
  Rat  1134 VLAAFVQRSTVLSKDRSKVIEDPEKYDPLFMHPDL---SCGTHTGSCGHAMHAHCWQRYFDSVQA 1195

  Fly  1193 KELRRPHRNRAALA-QAANVEFQCPYCRTLSNAIIPVTETLPA---------FSAPPSPNESYLP 1247
            ||.||..|.|...: ...|.||.||.|..|||.:||:  .||.         ||..|...:....
  Rat  1196 KEQRRQQRLRLHTSYDVENGEFLCPLCECLSNTVIPL--LLPPRSILSRRLNFSDQPDLAQWTRT 1258

  Fly  1248 LDSFVEIMSTLAIELGNVKDHELTTLPSVSNILRLSGVVGGLAQFERSVQLIKNPPRLHAD---- 1308
            :...::::..|.      |.......||              ::....:.:|..|.....|
  Rat  1259 IAQQIKVIQMLR------KGDSAADKPS--------------SEDTEDMNIIPIPEGFRPDFYPR 1303

  Fly  1309 --YIEGIEFLKKALLNTM--KIQQSHLKDHPAIESIEMVPIL-WDSCSYTLQALEIYLYAVEKPL 1368
              |.:.|    |.:|.|.  ...:..||.||. |....|||: |.:|:||:|::|..|...|||:
  Rat  1304 NPYSDSI----KEMLTTFGTATYKVGLKVHPN-EDDPRVPIMCWGTCAYTIQSIERILSEEEKPV 1363

  Fly  1369 KAELSMRHQSCARNLVRACSRSSALEWETDLPLLPPMRSQ-AEFSSRLLDTIFNQNDTSVLEWDC 1432
            ...|..|...|.|:|    :|.:|..|  .:.|||.::.. .:..:.|:.:..:::...:|:.|.
  Rat  1364 FGPLPCRLDDCLRSL----TRFAAAHW--TVALLPVVQGHFCKLFASLVPSDGSEDLPCILDIDM 1422

  Fly  1433 FRVLVPFQFGVLNLMVPEKGYKTIIPSGSMF---DFYIMQTMFLAQLTKAVLCFDVEKEKAKRAE 1494
            |.:||.     |.|..|....:..  |||..   |.:|...:.||.:.:.:|....|:....:..
  Rat  1423 FHLLVG-----LVLSFPALQCQDF--SGSSLATGDLHIFHLVTLAHIVQILLTSCTEENGMDQEN 1480

  Fly  1495 KAPNSELTQLDYIEQLPSRIRDNMIDFYRRYNIPARVLQKTKQKQLVEEESEENQG-HGQTVVIP 1558
            .....||..|.                          |.||..:.......|...| |
  Rat  1481 PTGEEELAILS--------------------------LHKTLHRCTGSALDEAPSGWH------- 1512

  Fly  1559 CESHHLALLLEYVQRQMSSFLRCSCLFYRFLTDVDFPDTFPTDQPDRFDLMCQYLGLDPMLGVYF 1623
                    |...|:..:..||:||.||:.:|..|..|..........|:.:|.||.|...|...|
  Rat  1513 --------LWRSVRAGILPFLKCSALFFHYLNGVPAPPDLQVSGASHFEHLCNYLSLPTNLIRLF 1569

  Fly  1624 DMETVYATMMHSFASHPHIDREVEQRCQ-PDARRSLQVEPCLRPLPR----LKVLCDDFSDLINS 1683
            ...   :.:|:|.         :|..|| .:.:|.|..|......||    |..|.:|:|.|||.
  Rat  1570 QEN---SDIMNSL---------IESWCQNSEVKRYLNGERGAISYPRGANKLIDLPEDYSSLINQ 1622

  Fly  1684 VSDIFCPNNEREEMKTPTMCLICGLILCGQSYCCQPELGKVSVGACTHHAHACGAEVGIFLRIRD 1748
            .|:..||.:..::.:.||:||:||.:||.||||||.||....|||||.|.::||:..|||||:|:
  Rat  1623 ASNFSCPKSGGDKSRAPTLCLVCGSLLCSQSYCCQAELEGEDVGACTAHTYSCGSGAGIFLRVRE 1687

  Fly  1749 CQVVYL-GRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWLGHGLHGEIARLNDN 1812
            |||::| |:.||||..|||||:|||||.||||||||.|.|..:|||...|..|.:..||....:.
  Rat  1688 CQVLFLAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCQERFRKIQKLWQQHSITEEIGHAQEA 1752

  Fly  1813 ANVAAAAQWHHM 1824
            ........|.|:
  Rat  1753 NQTLVGIDWQHL 1764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubr1	NP_001245723.1	zf-UBR	109..176	CDD:280386	47/66 (71%)
Ubr1	NP_001245723.1	ClpS	236..301	CDD:280736	26/64 (41%)
Ubr2	XP_038939742.1	zf-UBR	99..166	CDD:396677	47/66 (71%)
		ClpS	222..300	CDD:396950	29/87 (33%)
		RING_Ubox	1116..1231	CDD:418438	41/117 (35%)
		RING-H2 finger (C3H2C3-type)	1117..1222	CDD:319361	37/107 (35%)
		PRT6_C	1319..1739	CDD:408765	157/486 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343839
Domainoid	1	1.000	721	1.000	Domainoid score	I107
eggNOG	1	0.900	-	-		E1_KOG1140
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H26151
Inparanoid	1	1.050	899	1.000	Inparanoid score	I362
OMA	1	1.010	-	-		QHG59210
OrthoDB	1	1.010	-	-		D34639at33208
OrthoFinder	1	1.000	-	-		FOG0001341
OrthoInspector	1	1.000	-	-		otm45860
orthoMCL	1	0.900	-	-		OOG6_101603
Panther	1	1.100	-	-	O	PTHR21497
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810