Protein Alignment Ubr1 and ubr1

DIOPT Version :10

• Sequence 1: NP_573184.1
• Gene: Ubr1 / 32687
• FlyBaseID: FBgn0030809
• Length: 1824
• Species: Drosophila melanogaster
• Sequence 2: NP_596158.2
• Gene: ubr1 / 2540764
• PomBaseID: SPBC19C7.02
• Length: 1958
• Species: Schizosaccharomyces pombe
• Alignment Length: 2116
• Identity: 456/2116 - (21%)
• Similarity: 787/2116 - (37%)
• Gaps: 575/2116 - (27%)

  Fly    69 MFKESLAKEEIIDVVVEFMLG-----------DNPS-------------SALEKLRLEGNTATVC 109
            ::.|| ||:.:::.|...:||           :.|:             |..::.| .|...:.|
pombe    34 LWSES-AKKSLLNEVFSALLGYDHTLWNTLLPERPTIDASFLLRRAQGHSEGDEYR-HGTCESKC 96

  Fly   110 GKVFKNGEPTYSCRECGVDPTCVLCVNCFKRSAHRFHKYKMSTS-GGGGCCDCGDDEAWKKDQYC 173
            |.:|:.||..|.|:.|.||....|||.||:.::|:.|:...:.| |.|||||||:..||..|..|
pombe    97 GHIFRKGEVFYRCKTCSVDSNSALCVKCFRATSHKDHETSFTVSAGSGGCCDCGNAAAWIGDVSC 161

  Fly   174 ELHLANRKNPLESKILTDAVLERVE----ICFGAILAFCVSYLEIEPN--ASLQCLDGNVEG--- 229
            ::| ::.::...|..:.|.:.|::|    .....:|.|.:......|.  ..:..|:..::.
pombe   162 KIH-SHEEDATISNDMIDEIPEKLENSIQTTIDCVLDFVLDVFSCSPENLKKMPTLESILQDEKT 225

  Fly   230 --------GQVDGA--QYCTVLYNDESHTFDQVIQTLTKIAKCRAKDAMEIVAAIDREGRAVVKC 284
                    |.:|.:  .|..||:|||.|:|.|..:.:|        .|:|:...:..:..|.:..
pombe   226 SRLSENKYGDIDDSCNMYSLVLWNDEKHSFKQFYEQIT--------TALELPNNVFGKKMANIIN 282

  Fly   285 DTFEECNKLKVSIENQMILPTSLVSTARNNQSLRTSVLHIGAVACQQFALQLLGWFQEF------ 343
            |....|...:.:|:..:.:...|...     :|..|:..:..:..::....||.|..:.
pombe   283 DIGRACIVTETNIKELLKIGQKLAQI-----NLAVSIRSMRDIFREESCAVLLEWLADIAGSSIC 342

  Fly   344 -------------LVRHY---------LFR--------------------------------KTF 354
                         |||.:         .||                                .|.
pombe   343 GKRNYFSSVICKELVRPWNCGLHNSDLTFRLSLRSLALPEIVAIDSPDIFLNEDHINSSGPSDTS 407

  Fly   355 SELVQRKQETFCIRH---------ILE------------YDVKLWKTARTCWHRLLISGMLMEYD 398
            |.:::..:.:...||         :|.            ||:||||:.|.....|.:...:.:..
pombe   408 SHMLETDESSIHSRHWYPSNSLPDVLSYASRVRFDYFFLYDLKLWKSLRYKLQELYLGYFITQPG 472

  Fly   399 NKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAHHLIAHEGIFDKL------L 457
            .|.|:....:..|..:.|.|:..|.:...|::..|:|:|||..:|..|:..   :|.|      |
pombe   473 FKEIMGARIAISYRRLAELFLLLDREPEHSVIFFSMQIFTVADVAKLLVTE---YDFLTTINATL 534

  Fly   458 HTFY---------HVAIEKFIRNKTLHFSKNIASLTFFKRANYILYDLRYLLSLK--PDVLSNDL 511
            :||:         :|.....||..:..|..        :|..:|.:.::::||:.  .:::..||
pombe   535 YTFFTYKKLNTPNYVDQHAMIRTDSAAFHS--------RRYIHIFHHIQFMLSIPCVAEIVREDL 591

  Fly   512 RNGFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPE-WECAFNLHIKLATTISQVIDWASGDVK 575
            :  ||   :......|:.|||...||...||:::|.: |....|:.:::|.....|     |:|.
pombe   592 K--FL---KQYADFFNLFQGMCPYTRAVSQHVEWENDSWMYVLNVSLQVAKLCRHV-----GNVF 646

  Fly   576 LLRKLYKM--TMRALVSNSFIVGGEKVMQPKK---------------VADHVAN--CLVYDISVQ 621
            :.....|:  .:..|:|        .::.||.               ..|...|  .:.|||::|
pombe   647 MELNTNKLANAINYLIS--------LILYPKARNESWTNTESLTTGITVDERGNSKLIEYDIALQ 703

  Fly   622 PVSIHLPLSRFFAGIYLHLGAHDLTYDGLQTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWR 686
            |||.|.||......:.......| .|..|.|:.:.|::...|..:     |  |.::|:.|.||.
pombe   704 PVSFHHPLHWLLVYLLSFYVERD-NYKLLWTQLDLLAVTDHPLRV-----C--AWLSQMRAKLWI 760

  Fly   687 RNGYTLLHQLYFYRNVRCRVEMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLS 751
            |||.||..|.:.|||:.......|.|:..||:..:..:.:..|...::||.    |::..:....
pombe   761 RNGTTLRDQAHHYRNLSFHEYTFDLDVLLLQLTLTYGDPDAILPSFISRFQ----LEDQMYGRFF 821

  Fly   752 GNEMNDDIIREASIFDEFLELLIVIIG-----ERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSE 811
            ....:.|:.:...:.:|||.|||.|:.     :.|     .:|.  |:...|..:||.:|..:||
pombe   822 VPHKHYDVSQVTIMMEEFLLLLISIVCNTAVLDHW-----DITR--RIEYGIAHILCFRPLPYSE 879

  Fly   812 LSRALPDGNSGNSDNVFEEVINTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAE 876
            :::...:....:..  ||..:..||.|:...|.:..|.:.||:......:.:..||::..:.:||
pombe   880 ITKRTCEHLLEHKQ--FESTLKKVATFRNAEGINDSGSFTLKDEYFDYVDPFNIHYSRNQREEAE 942

  Fly   877 ELQRER--RKAKKQLVCCPPPMLPKLTPAFTPMAN------ILQCPVFLNIC-SLIMERALNAYS 932
            .:.|.|  ::..|.|...       :...:.|:.:      |||...|:.|. ..|:...:..|.
pombe   943 NILRRRYSKQHSKHLESV-------VYEEYHPILHSNITIPILQSDSFVGILWHTIVYAYIYPYD 1000

  Fly   933 RSFTESHLQKVLH-LLGYAIQEELSEHYPFLSFYERSQEYGILEKLEELARCP---------RLE 987
            :...|..:...|| .|...:.|:.||  |..|.......:.::|.|:|....|         :::
pombe  1001 QGKLEGLVNTALHACLLVLMSEKGSE--PIFSKKICENRFPVVEGLQEYCNSPDVTLFSVLCQMK 1063

  Fly   988 AHYDFVLWTIERFKQLQAKQAPSDGRAGPSCSQQGTGGKLSLS----------AEEQAREERENR 1042
            .|.:||.  ::....|..|...|:   .|...:......||:|          ||:|  |:...:
pombe  1064 NHRNFVY--VKEKISLIMKILKSE---VPLLYEPVYAETLSISSSKIVQSLSDAEQQ--EQHLAK 1121

  Fly  1043 ARLAAERRAHIMAQMQKAQKSFISSNAEMF--ADTENETRKESASTG----------PMD----- 1090
            .|:|.||:|.||.|.:..|..|:.::| :|  :|.|.:...|.:.|.          |:|
pombe  1122 VRMAKERQARIMEQFRMQQNKFLENHA-LFEASDCEMDEADEFSVTSSVSTKLFLDPPIDTCLLC 1185

  Fly  1091 WEDIPPEEEQGAV--ALESKVACLGP----------------------DRKFYHGTDDTFKCIL- 1130
            .|::..:...|.:  .|.|.|..|.|                      :|.|  |.....|.:|
pombe  1186 QEELKDKRPYGTLVFVLRSSVLRLFPADDANYVSEVLDIPDSLDHEIQERPF--GLAGKRKKVLD 1248

  Fly  1131 -----CFENCAISRGGRQLVSSAFVQTSRVIFTTPNLRNS---------QSALHISCCGHVMHYS 1181
                 .::|....:.|.:|               ..|::|         ...||.:.|||.||..
pombe  1249 STEAYDYDNYYYEKKGNEL---------------HQLKDSFNGFPPDQLDRGLHATGCGHFMHID 1298

  Fly  1182 CWLEYFTNEEFKELRRPHRNRAALAQAANVEFQCPYCRTLSNAIIPVTETLPAFSAPPSPNESYL 1246
            |:..:...........|:||..  ...:..||.||.|:.|.|.|.|:..         .|.|
pombe  1299 CFKNHIATVTLATRANPYRNHP--HNLSMKEFLCPLCKALCNTIFPILW---------RPKE--- 1349

  Fly  1247 PLDSFVEIMSTLAIELGNVKDHELTTLPSVSNILRLSGVVGGLAQFERSV--QL--IKNPPRLHA 1307
                  ||         |.::..:.|.| :.|.|     |.....|.:.:  ||  |:..|..|.
pombe  1350 ------EI---------NFQEAGVLTAP-LKNWL-----VSKTFSFNKDLNQQLLDIETSPSEHT 1393

  Fly  1308 DYIEGIEFLKKALLNTMKIQQSHLKDHPAIESIEMVPILWDSCSYTLQALEIYLYAVEKPLKAEL 1372
            ....         ||.:.:.|..|:|  :::.|..:....|:.|..::.....|:.     .:.|
pombe  1394 QSYN---------LNLLDVLQHTLRD--SLKDIYTLNTGADNSSDNVEENADNLFQ-----SSVL 1442

  Fly  1373 SMRH-QSCARNLVRACSRSSALEWETDLPLLPPMRSQAEFSSRLLDTIFNQNDTSVLEWDCF--- 1433
            ...| :|...|.|.|..|.:..:...:|             .|.||.:.:.|  |.|..|.|
pombe  1443 DHVHFKSVVNNEVPADERLAISDDIFEL-------------YRRLDDVIDLN--SSLYSDDFIPV 1492

  Fly  1434 -----RVLVPFQFGVLNLMVPEKGY--KTIIPSGSMFDFYI-----MQTMFLAQLTKAV-----L 1481
                 .|:..|.:.:..:....:|:  .:.||:    |.::     .|.:||..|::::     |
pombe  1493 NGKLHNVVKLFSYSLCQVEASTRGHIKCSSIPA----DIWVHNLGKNQQVFLRILSESIKTYTLL 1553

  Fly  1482 CFDVEKEKAKRAEKAPNSELTQLDYIEQLPSRIRDNMIDFYRRYNIPARVLQK-----TK----- 1536
            |       |..::|.....:.:.::            |.|.::..|..|:|..     ||
pombe  1554 C-------AHDSQKRIGGSIQEFEF------------ISFCQQKRIFGRLLPSLDSPVTKSITDD 1599

  Fly  1537 --QKQLVEEESEENQGHGQTVVIPC-ESHHLALLLEY----------VQRQMSSFLRCSCLFYRF 1588
              :..||::...|......:.::.| ||.|....|.|          :..|.:|.|:|
pombe  1600 RVEPLLVKDTFREFAEASVSGLLSCDESFHYLTQLYYTADIVRNLWILLSQRNSLLKC------- 1657

  Fly  1589 LTDVDFPDTFPTDQPDRFD-LMCQY---LGLDPMLGVYFD------------METVYATMMH--- 1634
            :..|:| :.|..:|...|: |:.|.   |.:|....:.||            :.|:|..:..
pombe  1658 MESVEF-EAFDYEQLKGFEHLVIQIWKSLRVDGAGLINFDCCTEDDLNNPHLLFTLYKLLERFSL 1721

  Fly  1635 ----------------SFASHPHIDREVEQRCQPDARR------SLQVEPCLRPLPR----LKVL 1673
                            ||.:.|:::.:..:..:...:.      .|....||.....    :|..
pombe  1722 IFLRKCALLWYCRYGVSFETQPNLNFQNSELSRLQTKMHIPGVIELSNHLCLTASSTEWSLIKHW 1786

  Fly  1674 CDDFSDL-----------------------INSVSDIF----CPNNEREEMKTPTMCLICGLILC 1711
            |:.|::.                       ::.|.::.    |.....|.|: |.:||.||.:||
pombe  1787 CNFFTETGPLCDFPRAYYPGIYELVSLPYELDKVFELLLARRCSKCLTEPME-PAICLFCGKLLC 1850

  Fly  1712 GQSYCCQPELGKVSVGACTHHAHACGAEVGIFLRIRDCQVVYLGRGKGCFVPPPYLDEYGETDMG 1776
            .||:||...    .:|.|..|...|.:::||||.::.|.::||....|.|...|:||.|||||:|
pombe  1851 FQSHCCSFN----GIGECNLHMQQCASDIGIFLIVKKCAILYLNPPVGSFSVAPFLDAYGETDLG 1911

  Fly  1777 LRRGNPLRLSQAAY-RKIYLQWLGHGLHGEIARLND 1811
            ||||....|||..| ..:...||...:...|||..|
pombe  1912 LRRGRSQYLSQKRYDETVRTMWLNGSIPSYIARQLD 1947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr1	NP_573184.1	UBR-box_UBR1_like	108..176	CDD:439070	30/68 (44%)
		ClpS	236..301	CDD:460621	16/64 (25%)
		RING-H2_UBR1-like	1166..1227	CDD:438145	19/60 (32%)
		PRT6_C	1345..1799	CDD:465944	121/570 (21%)
ubr1	NP_596158.2	UBR-box_UBR3	94..165	CDD:439071	31/71 (44%)
		RING-H2_UBR1-like	1285..1342	CDD:438145	19/58 (33%)
		PRT6_C	1474..1935	CDD:465944	109/498 (22%)