DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ubr1 and UBR2

DIOPT Version :9

Sequence 1:	NP_001245723.1	Gene:	Ubr1 / 32687	FlyBaseID:	FBgn0030809	Length:	1824	Species:	Drosophila melanogaster
Sequence 2:	XP_011512740.2	Gene:	UBR2 / 23304	HGNCID:	21289	Length:	1782	Species:	Homo sapiens

Alignment Length:	1912	Identity:	628/1912 - (32%)
Similarity:	943/1912 - (49%)	Gaps:	257/1912 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DVVVAPPAECS------SPLKEWRLKRQAGTLDRSDIIEFLKRESPKYFDYQTSATVKDTNVITL 66
            ||:..|..:..      ||..:|   .||..|.| ::.:.|....||.:       .:..|....
Human    33 DVLEQPDPDLGKQLCRPSPCGKW---LQATDLTR-EVYQHLAHYVPKIY-------CRGPNPFPQ 86

  Fly    67 KCMFKESLAKEEIIDVVVEFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTC 131
            |   ::.||:..::..:..::.|::|:....||......:.:||:|||.||||||||:|.|||||
Human    87 K---EDMLAQHVLLGPMEWYLCGEDPAFGFPKLEQANKPSHLCGRVFKVGEPTYSCRDCAVDPTC 148

  Fly   132 VLCVNCFKRSAHRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELHLAN------RKNPLESKILT 190
            |||:.||..|.||.|:|:|:||||||.|||||.||||:..||:.|..|      .::||..  |:
Human   149 VLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDPLVH--LS 211

  Fly   191 DAVLERVEICFGAILAFCVSYLEIEPNASLQCLDGNVEGGQVDGAQYCTVLYNDESHTFDQVIQT 255
            :.|:.|....|.....:.|..|..|..:.   |..::|..:.....|| :|:|||.||::|||.|
Human   212 EDVIARTYNIFAITFRYAVEILTWEKESE---LPADLEMVEKSDTYYC-MLFNDEVHTYEQVIYT 272

  Fly   256 LTKIAKCRAKDAMEIVAAIDREGRAVVKCDTFEECNKLK-VSIENQMILPTSLVSTARNNQSLRT 319
            |.|...|..|:|:.....:||:||..|:...|:.|.:.| |.:.|          |:|..:.|:.
Human   273 LQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRN----------TSRQTKPLKV 327

  Fly   320 SVLHIGAVACQQFALQLLGWFQEFL-----VRHYLFRKTFSELVQRKQETFCIRHILEYDVKLWK 379
            .|:|...||.|.|.|:||.|....:     :|..|.:....|....:..:...|.:|. |.||||
Human   328 QVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRRILCQVGLQEGPDGENSSLVDRLMLS-DSKLWK 391

  Fly   380 TARTCWHRLLISGMLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAH 444
            .||:.:|:|.:|.:||:...|.:.|..|::.|..:..|:::||||..||:..||||:|||||:|.
Human   392 GARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYERLQSDYVTDDHDREFSVADLSVQIFTVPSLAR 456

  Fly   445 HLIAHEGIFDKLLHTFYHVAIEKFIRNK----TLHFSKNIASLTF-FKRANYILYDLRYLLSLKP 504
            .||..|.:...::.||.     ..:|::    ...|.:..|...| |:|...::.||:|:|..||
Human   457 MLITEENLMSIIIKTFM-----DHLRHRDAQGRFQFERYTALQAFKFRRVQSLILDLKYVLISKP 516

  Fly   505 DVLSNDLRNGFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDW 569
            ...|::||..||||..|.:.:|..||||:.:|||.|||::.|||||.||.|.:||...||.:.||
Human   517 TEWSDELRQKFLEGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMMQDW 581

  Fly   570 ASGDVKLLRKLYKMTMRALVS-NSFIVGGEKVMQP--KKVADHVANCLVYDISVQPVSIHLPLSR 631
            .:.|.|:|.:.||..:..|:. :.....||   ||  ..:..|....:.|.:|.:.||||||:||
Human   582 CASDEKVLIEAYKKCLAVLMQCHGGYTDGE---QPITLSICGHSVETIRYCVSQEKVSIHLPVSR 643

  Fly   632 FFAGIYLHLGAHDLTYDGLQTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNGYTLLHQL 696
            ..||:::.|...::.|.  ..|...|| :|:|..:||..|....:.|||.||:|||||::|::|:
Human   644 LLAGLHVLLSKSEVAYK--FPELLPLS-ELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQI 705

  Fly   697 YFYRNVRCRVEMLDRDIACLQIGASLMESNEFLIHVLNRFNTIP-WLQENYWSLLSGNEMNDDII 760
            |:|.||:||.||.|:|:..||.|.|:|:.|.||:.:|:||.... :...:|....|....:.|::
Human   706 YYYHNVKCRREMFDKDVVMLQTGVSMMDPNHFLMIMLSRFELYQIFSTPDYGKRFSSEITHKDVV 770

  Fly   761 RE-ASIFDEFLELLIVIIGERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNS 824
            :: .::.:|.|.|:|:::|||:.|||..|...|.:::|||..|.|||.:||||.::||:..  |.
Human   771 QQNNTLIEEMLYLIIMLVGERFSPGVGQVNATDEIKREIIHQLSIKPMAHSELVKSLPEDE--NK 833

  Fly   825 DNVFEEVINTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQL 889
            :...|.||..||.|||| |...:|:||||....||||:||||:::.::|||||.||:.::..::.
Human   834 ETGMESVIEAVAHFKKP-GLTGRGMYELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRQNRED 897

  Fly   890 VCCPPPMLPKLTPAFTPMANILQCPVFLNICSLIMERALNAYSRSFTESHLQKVLHLLGYAIQEE 954
            ...|||:||...|.|..:.||||..|.|.|...|::.|:.....:::||.||:||||:|.|:|||
Human   898 TALPPPVLPPFCPLFASLVNILQSDVMLCIMGTILQWAVEHNGYAWSESMLQRVLHLIGMALQEE 962

  Fly   955 -------LSEHYPFLSFYERSQEYG--------ILEKLEELARCPRLEAHYDFVLWTIERFKQLQ 1004
                   ..||....:|.::..:.|        ||..||.|...|.||.|.|.:.|.::.|..:
Human   963 KQHLENVTEEHVVTFTFTQKISKPGEAPKNSPSILAMLETLQNAPYLEVHKDMIRWILKTFNAV- 1026

  Fly  1005 AKQAPSDGRAGPSCSQQGTGGKLSLSAEEQAREERENRARLAAERRAHIMAQMQKAQKSFISSNA 1069
             |:........|....:||  .:..|:.::.:.||:.:|.:|..||..|||||.:.|:.||..|.
Human  1027 -KKMRESSPTSPVAETEGT--IMEESSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENK 1088

  Fly  1070 EMFADTENETRKESASTGPMDWEDIPPEEEQGAVALESKVACLGP-------DRKFYHGTDDTFK 1127
            |:|    .:|.:..|||..:        .:...||.:..:..|||       .|:|       ..
Human  1089 ELF----QQTLELDASTSAV--------LDHSPVASDMTLTALGPAQTQVPEQRQF-------VT 1134

  Fly  1128 CILCFENCAISRGGRQLVSSAFVQTSRV-----------------IFTTPNLRNSQSALHISCCG 1175
            ||||.|...:....|.:|.:||||.|.|                 :|..|:|   ....|.|.||
Human  1135 CILCQEEQEVKVESRAMVLAAFVQRSTVLSKNRSKFIQDPEKYDPLFMHPDL---SCGTHTSSCG 1196

  Fly  1176 HVMHYSCWLEYFTNEEFKELRRPHRNRAALA-QAANVEFQCPYCRTLSNAIIPVTETLPA----- 1234
            |:||..||..||.:.:.||.||..|.|...: ...|.||.||.|..|||.:||:  .||.
Human  1197 HIMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVENGEFLCPLCECLSNTVIPL--LLPPRNIFN 1259

  Fly  1235 ----FSAPPSPNESYLPLDSFVEIMSTLAIELGNVKDHELTTLPSVSNILRLSGVVGGLAQFERS 1295
                ||..|:..:....:...::.:..|.      |:.......|..|              ..:
Human  1260 NRLNFSDQPNLTQWIRTISQQIKALQFLR------KEESTPNNASTKN--------------SEN 1304

  Fly  1296 VQLIKNPPRLHADY---IEGIEFLKKALLN----TMKIQQSHLKDHPAIESIEMVPIL-WDSCSY 1352
            |..::.|.....|:   |...|.:|:.|..    |.|:   .||.||. |....|||: |.||:|
Human  1305 VDELQLPEGFRPDFRPKIPYSESIKEMLTTFGTATYKV---GLKVHPN-EEDPRVPIMCWGSCAY 1365

  Fly  1353 TLQALEIYLYAVEKPLKAELSMRHQSCARNLVRACSRSSALEWE-TDLPLLPPMRSQAEFSSRLL 1416
            |:|::|..|...:|||...|..|...|.|:|    :|.:|..|. ..:.::     |..|.....
Human  1366 TIQSIERILSDEDKPLFGPLPCRLDDCLRSL----TRFAAAHWTVASVSVV-----QGHFCKLFA 1421

  Fly  1417 DTIFNQNDTS---VLEWDCFRVLVPFQFGVLNLMVPE---KGYKTI-IPSGSMFDFYIMQTMFLA 1474
            ..:.|.:...   :|:.|.|.:||.     |.|..|.   :.:..| :.:|.:..|:::....:.
Human  1422 SLVPNDSHEELPCILDIDMFHLLVG-----LVLAFPALQCQDFSGISLGTGDLHIFHLVTMAHII 1481

  Fly  1475 QLTKAVLCFDVEKEKAKRAEKAPNSELTQLDYIEQLPSRIRDNMIDFYRRYNIPARVLQKTKQKQ 1539
            |    :|.....:|.....|..|..|              ...::..|       :.|.:.....
Human  1482 Q----ILLTSCTEENGMDQENPPCEE--------------ESAVLALY-------KTLHQYTGSA 1521

  Fly  1540 LVEEESEENQGHGQTVVIPCESHHLALLLEYVQRQMSSFLRCSCLFYRFLTDVDFPDTFPTDQPD 1604
            |.|              ||...|    |...|:..:..||:||.||:.:|..|..|.........
Human  1522 LKE--------------IPSGWH----LWRSVRAGIMPFLKCSALFFHYLNGVPSPPDIQVPGTS 1568

  Fly  1605 RFDLMCQYLGL-DPMLGVYFDMETVYATMMHSFASHPHIDREVEQRCQPDARRSLQVEPCLRPLP 1668
            .|:.:|.||.| :.::.::.:...:..:::.|:..:..:.|.:|.  :.||.|..:....|..||
Human  1569 HFEHLCSYLSLPNNLICLFQENSEIMNSLIESWCRNSEVKRYLEG--ERDAIRYPRESNKLINLP 1631

  Fly  1669 RLKVLCDDFSDLINSVSDIFCPNNEREEMKTPTMCLICGLILCGQSYCCQPELGKVSVGACTHHA 1733
                  :|:|.|||..|:..||.:..::.:.||:||:||.:||.||||||.||....|||||.|.
Human  1632 ------EDYSSLINQASNFSCPKSGGDKSRAPTLCLVCGSLLCSQSYCCQTELEGEDVGACTAHT 1690

  Fly  1734 HACGAEVGIFLRIRDCQVVYL-GRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQW 1797
            ::||:.||||||:|:|||::| |:.||||..|||||:|||||.||||||||.|.:..::||...|
Human  1691 YSCGSGVGIFLRVRECQVLFLAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCKERFKKIQKLW 1755

  Fly  1798 LGHGLHGEIARLNDNANVAAAAQWHHM 1824
            ..|.:..||....:.........|.|:
Human  1756 HQHSVTEEIGHAQEANQTLVGIDWQHL 1782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubr1	NP_001245723.1	zf-UBR	109..176	CDD:280386	47/66 (71%)
Ubr1	NP_001245723.1	ClpS	236..301	CDD:280736	27/65 (42%)
UBR2	XP_011512740.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149947
Domainoid	1	1.000	732	1.000	Domainoid score	I105
eggNOG	1	0.900	-	-		E1_KOG1140
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H26151
Inparanoid	1	1.050	905	1.000	Inparanoid score	I374
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59210
OrthoDB	1	1.010	-	-		D34639at33208
OrthoFinder	1	1.000	-	-		FOG0001341
OrthoInspector	1	1.000	-	-		otm41728
orthoMCL	1	0.900	-	-		OOG6_101603
Panther	1	1.100	-	-	O	PTHR21497
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1593
SonicParanoid	1	1.000	-	-		X1260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800