Protein Alignment Ubr1 and UBR2

DIOPT Version :10

• Sequence 1: NP_573184.1
• Gene: Ubr1 / 32687
• FlyBaseID: FBgn0030809
• Length: 1824
• Species: Drosophila melanogaster
• Sequence 2: XP_011512740.2
• Gene: UBR2 / 23304
• HGNCID: 21289
• Length: 1782
• Species: Homo sapiens
• Alignment Length: 1912
• Identity: 628/1912 - (32%)
• Similarity: 943/1912 - (49%)
• Gaps: 257/1912 - (13%)

  Fly     8 DVVVAPPAECS------SPLKEWRLKRQAGTLDRSDIIEFLKRESPKYFDYQTSATVKDTNVITL 66
            ||:..|..:..      ||..:|   .||..|.| ::.:.|....||.:       .:..|....
Human    33 DVLEQPDPDLGKQLCRPSPCGKW---LQATDLTR-EVYQHLAHYVPKIY-------CRGPNPFPQ 86

  Fly    67 KCMFKESLAKEEIIDVVVEFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTC 131
            |   ::.||:..::..:..::.|::|:....||......:.:||:|||.||||||||:|.|||||
Human    87 K---EDMLAQHVLLGPMEWYLCGEDPAFGFPKLEQANKPSHLCGRVFKVGEPTYSCRDCAVDPTC 148

  Fly   132 VLCVNCFKRSAHRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELHLAN------RKNPLESKILT 190
            |||:.||..|.||.|:|:|:||||||.|||||.||||:..||:.|..|      .::||..  |:
Human   149 VLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDPLVH--LS 211

  Fly   191 DAVLERVEICFGAILAFCVSYLEIEPNASLQCLDGNVEGGQVDGAQYCTVLYNDESHTFDQVIQT 255
            :.|:.|....|.....:.|..|..|..:.   |..::|..:.....|| :|:|||.||::|||.|
Human   212 EDVIARTYNIFAITFRYAVEILTWEKESE---LPADLEMVEKSDTYYC-MLFNDEVHTYEQVIYT 272

  Fly   256 LTKIAKCRAKDAMEIVAAIDREGRAVVKCDTFEECNKLK-VSIENQMILPTSLVSTARNNQSLRT 319
            |.|...|..|:|:.....:||:||..|:...|:.|.:.| |.:.|          |:|..:.|:.
Human   273 LQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRN----------TSRQTKPLKV 327

  Fly   320 SVLHIGAVACQQFALQLLGWFQEFL-----VRHYLFRKTFSELVQRKQETFCIRHILEYDVKLWK 379
            .|:|...||.|.|.|:||.|....:     :|..|.:....|....:..:...|.:|. |.||||
Human   328 QVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRRILCQVGLQEGPDGENSSLVDRLMLS-DSKLWK 391

  Fly   380 TARTCWHRLLISGMLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAH 444
            .||:.:|:|.:|.:||:...|.:.|..|::.|..:..|:::||||..||:..||||:|||||:|.
Human   392 GARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYERLQSDYVTDDHDREFSVADLSVQIFTVPSLAR 456

  Fly   445 HLIAHEGIFDKLLHTFYHVAIEKFIRNK----TLHFSKNIASLTF-FKRANYILYDLRYLLSLKP 504
            .||..|.:...::.||.     ..:|::    ...|.:..|...| |:|...::.||:|:|..||
Human   457 MLITEENLMSIIIKTFM-----DHLRHRDAQGRFQFERYTALQAFKFRRVQSLILDLKYVLISKP 516

  Fly   505 DVLSNDLRNGFLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDW 569
            ...|::||..||||..|.:.:|..||||:.:|||.|||::.|||||.||.|.:||...||.:.||
Human   517 TEWSDELRQKFLEGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMMQDW 581

  Fly   570 ASGDVKLLRKLYKMTMRALVS-NSFIVGGEKVMQP--KKVADHVANCLVYDISVQPVSIHLPLSR 631
            .:.|.|:|.:.||..:..|:. :.....||   ||  ..:..|....:.|.:|.:.||||||:||
Human   582 CASDEKVLIEAYKKCLAVLMQCHGGYTDGE---QPITLSICGHSVETIRYCVSQEKVSIHLPVSR 643

  Fly   632 FFAGIYLHLGAHDLTYDGLQTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNGYTLLHQL 696
            ..||:::.|...::.|.  ..|...|| :|:|..:||..|....:.|||.||:|||||::|::|:
Human   644 LLAGLHVLLSKSEVAYK--FPELLPLS-ELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQI 705

  Fly   697 YFYRNVRCRVEMLDRDIACLQIGASLMESNEFLIHVLNRFNTIP-WLQENYWSLLSGNEMNDDII 760
            |:|.||:||.||.|:|:..||.|.|:|:.|.||:.:|:||.... :...:|....|....:.|::
Human   706 YYYHNVKCRREMFDKDVVMLQTGVSMMDPNHFLMIMLSRFELYQIFSTPDYGKRFSSEITHKDVV 770

  Fly   761 RE-ASIFDEFLELLIVIIGERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNS 824
            :: .::.:|.|.|:|:::|||:.|||..|...|.:::|||..|.|||.:||||.::||:..  |.
Human   771 QQNNTLIEEMLYLIIMLVGERFSPGVGQVNATDEIKREIIHQLSIKPMAHSELVKSLPEDE--NK 833

  Fly   825 DNVFEEVINTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQL 889
            :...|.||..||.|||| |...:|:||||....||||:||||:::.::|||||.||:.::..::.
Human   834 ETGMESVIEAVAHFKKP-GLTGRGMYELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRQNRED 897

  Fly   890 VCCPPPMLPKLTPAFTPMANILQCPVFLNICSLIMERALNAYSRSFTESHLQKVLHLLGYAIQEE 954
            ...|||:||...|.|..:.||||..|.|.|...|::.|:.....:::||.||:||||:|.|:|||
Human   898 TALPPPVLPPFCPLFASLVNILQSDVMLCIMGTILQWAVEHNGYAWSESMLQRVLHLIGMALQEE 962

  Fly   955 -------LSEHYPFLSFYERSQEYG--------ILEKLEELARCPRLEAHYDFVLWTIERFKQLQ 1004
                   ..||....:|.::..:.|        ||..||.|...|.||.|.|.:.|.::.|..:
Human   963 KQHLENVTEEHVVTFTFTQKISKPGEAPKNSPSILAMLETLQNAPYLEVHKDMIRWILKTFNAV- 1026

  Fly  1005 AKQAPSDGRAGPSCSQQGTGGKLSLSAEEQAREERENRARLAAERRAHIMAQMQKAQKSFISSNA 1069
             |:........|....:||  .:..|:.::.:.||:.:|.:|..||..|||||.:.|:.||..|.
Human  1027 -KKMRESSPTSPVAETEGT--IMEESSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENK 1088

  Fly  1070 EMFADTENETRKESASTGPMDWEDIPPEEEQGAVALESKVACLGP-------DRKFYHGTDDTFK 1127
            |:|    .:|.:..|||..:        .:...||.:..:..|||       .|:|       ..
Human  1089 ELF----QQTLELDASTSAV--------LDHSPVASDMTLTALGPAQTQVPEQRQF-------VT 1134

  Fly  1128 CILCFENCAISRGGRQLVSSAFVQTSRV-----------------IFTTPNLRNSQSALHISCCG 1175
            ||||.|...:....|.:|.:||||.|.|                 :|..|:|   ....|.|.||
Human  1135 CILCQEEQEVKVESRAMVLAAFVQRSTVLSKNRSKFIQDPEKYDPLFMHPDL---SCGTHTSSCG 1196

  Fly  1176 HVMHYSCWLEYFTNEEFKELRRPHRNRAALA-QAANVEFQCPYCRTLSNAIIPVTETLPA----- 1234
            |:||..||..||.:.:.||.||..|.|...: ...|.||.||.|..|||.:||:  .||.
Human  1197 HIMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVENGEFLCPLCECLSNTVIPL--LLPPRNIFN 1259

  Fly  1235 ----FSAPPSPNESYLPLDSFVEIMSTLAIELGNVKDHELTTLPSVSNILRLSGVVGGLAQFERS 1295
                ||..|:..:....:...::.:..|.      |:.......|..|              ..:
Human  1260 NRLNFSDQPNLTQWIRTISQQIKALQFLR------KEESTPNNASTKN--------------SEN 1304

  Fly  1296 VQLIKNPPRLHADY---IEGIEFLKKALLN----TMKIQQSHLKDHPAIESIEMVPIL-WDSCSY 1352
            |..::.|.....|:   |...|.:|:.|..    |.|:   .||.||. |....|||: |.||:|
Human  1305 VDELQLPEGFRPDFRPKIPYSESIKEMLTTFGTATYKV---GLKVHPN-EEDPRVPIMCWGSCAY 1365

  Fly  1353 TLQALEIYLYAVEKPLKAELSMRHQSCARNLVRACSRSSALEWE-TDLPLLPPMRSQAEFSSRLL 1416
            |:|::|..|...:|||...|..|...|.|:|    :|.:|..|. ..:.::     |..|.....
Human  1366 TIQSIERILSDEDKPLFGPLPCRLDDCLRSL----TRFAAAHWTVASVSVV-----QGHFCKLFA 1421

  Fly  1417 DTIFNQNDTS---VLEWDCFRVLVPFQFGVLNLMVPE---KGYKTI-IPSGSMFDFYIMQTMFLA 1474
            ..:.|.:...   :|:.|.|.:||.     |.|..|.   :.:..| :.:|.:..|:::....:.
Human  1422 SLVPNDSHEELPCILDIDMFHLLVG-----LVLAFPALQCQDFSGISLGTGDLHIFHLVTMAHII 1481

  Fly  1475 QLTKAVLCFDVEKEKAKRAEKAPNSELTQLDYIEQLPSRIRDNMIDFYRRYNIPARVLQKTKQKQ 1539
            |    :|.....:|.....|..|..|              ...::..|       :.|.:.....
Human  1482 Q----ILLTSCTEENGMDQENPPCEE--------------ESAVLALY-------KTLHQYTGSA 1521

  Fly  1540 LVEEESEENQGHGQTVVIPCESHHLALLLEYVQRQMSSFLRCSCLFYRFLTDVDFPDTFPTDQPD 1604
            |.|              ||...|    |...|:..:..||:||.||:.:|..|..|.........
Human  1522 LKE--------------IPSGWH----LWRSVRAGIMPFLKCSALFFHYLNGVPSPPDIQVPGTS 1568

  Fly  1605 RFDLMCQYLGL-DPMLGVYFDMETVYATMMHSFASHPHIDREVEQRCQPDARRSLQVEPCLRPLP 1668
            .|:.:|.||.| :.::.::.:...:..:::.|:..:..:.|.:|.  :.||.|..:....|..||
Human  1569 HFEHLCSYLSLPNNLICLFQENSEIMNSLIESWCRNSEVKRYLEG--ERDAIRYPRESNKLINLP 1631

  Fly  1669 RLKVLCDDFSDLINSVSDIFCPNNEREEMKTPTMCLICGLILCGQSYCCQPELGKVSVGACTHHA 1733
                  :|:|.|||..|:..||.:..::.:.||:||:||.:||.||||||.||....|||||.|.
Human  1632 ------EDYSSLINQASNFSCPKSGGDKSRAPTLCLVCGSLLCSQSYCCQTELEGEDVGACTAHT 1690

  Fly  1734 HACGAEVGIFLRIRDCQVVYL-GRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQW 1797
            ::||:.||||||:|:|||::| |:.||||..|||||:|||||.||||||||.|.:..::||...|
Human  1691 YSCGSGVGIFLRVRECQVLFLAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCKERFKKIQKLW 1755

  Fly  1798 LGHGLHGEIARLNDNANVAAAAQWHHM 1824
            ..|.:..||....:.........|.|:
Human  1756 HQHSVTEEIGHAQEANQTLVGIDWQHL 1782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr1	NP_573184.1	UBR-box_UBR1_like	108..176	CDD:439070	47/67 (70%)
		ClpS	236..301	CDD:460621	27/65 (42%)
		RING-H2_UBR1-like	1166..1227	CDD:438145	26/61 (43%)
		PRT6_C	1345..1799	CDD:465944	142/464 (31%)
UBR2	XP_011512740.2	UBR-box_UBR2	125..194	CDD:439077	47/68 (69%)
		ClpS	249..327	CDD:460621	30/88 (34%)
		RING-H2_UBR2	1134..1249	CDD:438347	42/117 (36%)
		PRT6_C	1337..1755	CDD:465944	150/486 (31%)