DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ubr1 and Ubr2

DIOPT Version :9

Sequence 1:	NP_001245723.1	Gene:	Ubr1 / 32687	FlyBaseID:	FBgn0030809	Length:	1824	Species:	Drosophila melanogaster
Sequence 2:	NP_001170845.1	Gene:	Ubr2 / 224826	MGIID:	1861099	Length:	1755	Species:	Mus musculus

Alignment Length:	1896	Identity:	626/1896 - (33%)
Similarity:	933/1896 - (49%)	Gaps:	245/1896 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ECSSP--LKEWRLKRQAGTLDRSDIIEFLKRESPKYFDYQTSATVKDTNVITLKCMFKESLAKEE 78
            |||:.  ...|   .||..|:| ::.:.|....||.:       .:..|....|   :::||:..
Mouse    18 ECSAEEIAGRW---LQATDLNR-EVYQHLAHCVPKIY-------CRGPNPFPQK---EDTLAQHI 68

  Fly    79 IIDVVVEFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNCFKRSAH 143
            ::..:..::..::|:....||......:.:||:|||.||||||||:|.||||||||:.||..|.|
Mouse    69 LLGPMEWYICAEDPALGFPKLEQANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIH 133

  Fly   144 RFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELH------LANRKNPLESKILTDAVLERVEICFG 202
            |.|:|:|:||||||.|||||.||||:..||:.|      :...::||..  |::.|:.|....|.
Mouse   134 RDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHKLSSSEVVEEEDPLVH--LSEDVIARTYNIFA 196

  Fly   203 AILAFCVSYLEIEPNASLQCLDGNVEGGQVDGAQYCTVLYNDESHTFDQVIQTLTKIAKCRAKDA 267
            .:..:.|..|..|..:.   |..::|..:.....|| :|:|||.||::|||.||.|...|..|:|
Mouse   197 IMFRYAVDILTWEKESE---LPEDLEVAEKSDTYYC-MLFNDEVHTYEQVIYTLQKAVNCTQKEA 257

  Fly   268 MEIVAAIDREGRAVVKCDTFEECNKLKVSIENQMILPTSLVSTARNNQSLRTSVLHIGAVACQQF 332
            :.....:||:||..|:...|:.|::.|..|         :.:|:|..:.|:..|:|....|.|.|
Mouse   258 IGFATTVDRDGRRSVRYGDFQYCDQAKTVI---------VRNTSRQTKPLKVQVMHSSVAAHQNF 313

  Fly   333 ALQLLGWFQEFL-----VRHYLFRKTFSELVQRKQETFCIRHILEYDVKLWKTARTCWHRLLISG 392
            .|:.|.|....:     :|..|.:....|....:..:...|.:|. |.||||.||:.:|:|.:|.
Mouse   314 GLKALSWLGSVIGYSDGLRRILCQVGLQEGPDGENSSLVDRLMLN-DSKLWKGARSVYHQLFMSS 377

  Fly   393 MLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAHHLIAHEGIFDKLL 457
            :||:...|.:.|..|::.|..:..|:::||||..||:..||||:|||||:|..|:..|.:...::
Mouse   378 LLMDLKYKKLFALRFAKNYERLQRDYVTDDHDREFSVADLSVQIFTVPSLARMLLTEENLMTVII 442

  Fly   458 HTFYHVAIEKFIRNKTLHFSKNIASLTF-FKRANYILYDLRYLLSLKPDVLSNDLRNGFLEGCRA 521
            ..|......:..:.: ..|.:..|...| |:|...::.||:|:|..||...|::||..||:|..|
Mouse   443 KAFMDHLKHRDAQGR-FQFERYTALQAFKFRRVQSLILDLKYVLISKPTEWSDELRQKFLQGFDA 506

  Fly   522 LMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDWASGDVKLLRKLYKMTMR 586
            .:.:|..||||:.:|||.|||::.|||||.||.|.:||...||.|.||.:.|.|:|.:.||..:.
Mouse   507 FLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMVQDWCALDEKVLIEAYKKCLA 571

  Fly   587 ALVS-NSFIVGGEKVMQP--KKVADHVANCLVYDISVQPVSIHLPLSRFFAGIYLHLGAHDLTYD 648
            .|.. :.....||   ||  ..:..|....:.|.:|.:.||||||:||..||:::.|...::.|.
Mouse   572 VLTQCHGGFTDGE---QPITLSICGHSVETIRYCVSQEKVSIHLPISRLLAGLHVLLSKSEVAYK 633

  Fly   649 GLQTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNGYTLLHQLYFYRNVRCRVEMLDRDI 713
              ..|...|| :|:|..:||..|....:.|||.||:|||||::|::|:|:|.||:||.||.|:||
Mouse   634 --FPELLPLS-ELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDI 695

  Fly   714 ACLQIGASLMESNEFLIHVLNRFNTIP-WLQENYWSLLSGNEMNDDIIRE-ASIFDEFLELLIVI 776
            ..||.|.|:|:.|.||:.:|:||.... :...:|....|....:.|:::: .::.:|.|.|:|::
Mouse   696 VMLQTGVSMMDPNHFLMIMLSRFELYQLFSTPDYGKRFSSEVTHKDVVQQNNTLIEEMLYLIIML 760

  Fly   777 IGERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSDNVFEEVINTVAVFKKP 841
            :|||:.|||..|...|.:::|||..|.|||.:||||.::||:..  |.:...|.||.:||.||||
Mouse   761 VGERFNPGVGQVAATDEIKREIIHQLSIKPMAHSELVKSLPEDE--NKETGMESVIESVAHFKKP 823

  Fly   842 VGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQLVCCPPPMLPKLTPAFTP 906
             |...:|:||||....||||:||||:::.::|||||.||:.::..|:....|||.||...|.|..
Mouse   824 -GLTGRGMYELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRENKEDTALPPPALPPFCPLFAS 887

  Fly   907 MANILQCPVFLNICSLIMERALNAYSRSFTESHLQKVLHLLGYAIQEE-------LSEHYPFLSF 964
            :.|||||.|.|.|...|::.|:..:..:::||.||:||||:|.|:|||       :..|....:|
Mouse   888 LVNILQCDVMLYIMGTILQWAVEHHGSAWSESMLQRVLHLIGMALQEEKHHLENAVEGHVQTFTF 952

  Fly   965 YERSQEYG--------ILEKLEELARCPRLEAHYDFVLWTIERFKQLQAKQAPSDGRAGPSCSQQ 1021
            .::..:.|        ||..||.|...|.||||.|.:.|.::.|..:  |:......:.|....:
Mouse   953 TQKISKPGDAPHNSPSILAMLETLQNAPSLEAHKDMIRWLLKMFNAI--KKIRECSSSSPVAEAE 1015

  Fly  1022 GTGGKLSLSAEEQAREERENRARLAAERRAHIMAQMQKAQKSFISSNAEMFADTENETRKESAST 1086
            ||  .:..|:.::.:.||:.:|.:|..||..|||||.:.|:.||..|.|:|..|.......||:.
Mouse  1016 GT--IMEESSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDTSASATL 1078

  Fly  1087 GPMDWEDIPPEEEQGAVALESKVACLGPDRKFYHGTDDTFKCILCFENCAISRGGRQLVSSAFVQ 1151
                 :..||..:....||......:...|:|       ..||||.|...::.|.|.:|.:||||
Mouse  1079 -----DSSPPVSDAALTALGPAQTQVPEPRQF-------VTCILCQEEQEVTVGSRAMVLAAFVQ 1131

  Fly  1152 TSRV-----------------IFTTPNLRNSQSALHISCCGHVMHYSCWLEYFTNEEFKELRRPH 1199
            .|.|                 :|..|:|   ....|...||||||..||..||.:.:.||.||..
Mouse  1132 RSTVLSKDRTKTIADPEKYDPLFMHPDL---SCGTHTGSCGHVMHAHCWQRYFDSVQAKEQRRQQ 1193

  Fly  1200 RNRAALA-QAANVEFQCPYCRTLSNAIIPVTETLPA---------FSAPPSPNESYLPLDSFVEI 1254
            |.|...: ...|.||.||.|..|||.:||:  .||.         ||..|...:....:...:::
Mouse  1194 RLRLHTSYDVENGEFLCPLCECLSNTVIPL--LLPPRSILSRRLNFSDQPDLAQWTRAVTQQIKV 1256

  Fly  1255 MSTL-----AIELGNVKDHELTTLPSVSNILRLSGVVGGLAQFERSVQLIKNPPRLHAD------ 1308
            :..|     |.:..:.:|.|                         ::.:|..|.....|
Mouse  1257 VQMLRRKHNAADTSSSEDTE-------------------------AMNIIPIPEGFRPDFYPRNP 1296

  Fly  1309 YIEGIEFLKKALLNTM--KIQQSHLKDHPAIESIEMVPIL-WDSCSYTLQALEIYLYAVEKPLKA 1370
            |.:.|    |.:|.|.  ...:..||.||. |....|||| |.:|:||:|::|..|...|||:..
Mouse  1297 YSDSI----KEMLTTFGTAAYKVGLKVHPN-EGDPRVPILCWGTCAYTIQSIERILSDEEKPVFG 1356

  Fly  1371 ELSMRHQSCARNLVRACSRSSALEWETDLPLLPPMRSQ-AEFSSRLLDTIFNQNDTSVLEWDCFR 1434
            .|..|...|.|:|    :|.:|..|  .:.|||.::.. .:..:.|:.:...::...:|:.|.|.
Mouse  1357 PLPCRLDDCLRSL----TRFAAAHW--TVALLPVVQGHFCKLFASLVPSDSYEDLPCILDIDMFH 1415

  Fly  1435 VLVPFQFGVLNLMVPEKGYKTIIPSGSMF---DFYIMQTMFLAQLTKAVLCFDVEKEKAKRAEKA 1496
            :||.     |.|..|....:..  |||..   |.:|...:.:|.:.:.:|....|:....:....
Mouse  1416 LLVG-----LVLAFPALQCQDF--SGSSLATGDLHIFHLVTMAHIVQILLTSCTEENGMDQENPT 1473

  Fly  1497 PNSELTQLDYIEQLPSRIRDNMIDFYRRYNIPARVLQKTKQKQLVEEESEENQG-HGQTVVIPCE 1560
            ...||..|.                          |.||..:.......|...| |
Mouse  1474 GEEELAILS--------------------------LHKTLHQYTGSALKEAPSGWH--------- 1503

  Fly  1561 SHHLALLLEYVQRQMSSFLRCSCLFYRFLTDVDFPDTFPTDQPDRFDLMCQYLGLDPMLGVYFDM 1625
                  |...|:..:..||:||.||:.:|..|..|..........|:.:|.||.|.
Mouse  1504 ------LWRSVRAAIMPFLKCSALFFHYLNGVPAPPDLQVSGTSHFEHLCNYLSLP--------- 1553

  Fly  1626 ETVYATMMHSFASHPHI-DREVEQRCQ-PDARRSLQVEPCLRPLPR----LKVLCDDFSDLINSV 1684
                ..::|.|..:..| :..:|..|| .:.:|.|..|......||    |..|.:|:|.|||..
Mouse  1554 ----TNLIHLFQENSDIMNSLIESWCQNSEVKRYLNGERGAISYPRGANKLIDLPEDYSSLINQA 1614

  Fly  1685 SDIFCPNNEREEMKTPTMCLICGLILCGQSYCCQPELGKVSVGACTHHAHACGAEVGIFLRIRDC 1749
            |:..||.:..::.:.||:||:||.:||.||||||.||....|||||.|.::||:..|||||:|:|
Mouse  1615 SNFSCPKSGGDKSRAPTLCLVCGSLLCSQSYCCQAELEGEDVGACTAHTYSCGSGAGIFLRVREC 1679

  Fly  1750 QVVYL-GRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWLGHGLHGEIARLNDNA 1813
            ||::| |:.||||..|||||:|||||.||||||||.|.|..:|||...|..|.:..||....:..
Mouse  1680 QVLFLAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCQERFRKIQKLWQQHSITEEIGHAQEAN 1744

  Fly  1814 NVAAAAQWHHM 1824
            .......|.|:
Mouse  1745 QTLVGIDWQHL 1755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubr1	NP_001245723.1	zf-UBR	109..176	CDD:280386	47/66 (71%)
Ubr1	NP_001245723.1	ClpS	236..301	CDD:280736	26/64 (41%)
Ubr2	NP_001170845.1	zf-UBR	99..166	CDD:280386	47/66 (71%)
		ClpS	222..300	CDD:280736	29/87 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1012..1033		5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839989
Domainoid	1	1.000	738	1.000	Domainoid score	I99
eggNOG	1	0.900	-	-		E1_KOG1140
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H26151
Inparanoid	1	1.050	911	1.000	Inparanoid score	I367
Isobase	1	0.950	-	0	Normalized mean entropy	S5556
OMA	1	1.010	-	-		QHG59210
OrthoDB	1	1.010	-	-		D34639at33208
OrthoFinder	1	1.000	-	-		FOG0001341
OrthoInspector	1	1.000	-	-		otm43776
orthoMCL	1	0.900	-	-		OOG6_101603
Panther	1	1.100	-	-	O	PTHR21497
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1593
SonicParanoid	1	1.000	-	-		X1260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750