Protein Alignment Ubr1 and UBR1

DIOPT Version :9

• Sequence 1: NP_001245723.1
• Gene: Ubr1 / 32687
• FlyBaseID: FBgn0030809
• Length: 1824
• Species: Drosophila melanogaster
• Sequence 2: NP_777576.1
• Gene: UBR1 / 197131
• HGNCID: 16808
• Length: 1749
• Species: Homo sapiens
• Alignment Length: 1921
• Identity: 610/1921 - (31%)
• Similarity: 922/1921 - (47%)
• Gaps: 307/1921 - (15%)

  Fly    29 QAGTLDRSDIIEFLKRESPK----YFDYQT---SATVKDTNVITLKCMFKE---SLAKEE----- 78
            :||..:|.:|...|. ::|:    ::|.|.   :|.:.....:..:..|.|   .|.|:|
Human     5 EAGGTERMEISAELP-QTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLEKQEESVQM 68

  Fly    79 -IIDVVVEFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLCVNCFKRSA 142
             |...:..::.|::|...||||:..| ...:||:|||:||.|||||:|.:|||||||::||:.|.
Human    69 SIFTPLEWYLFGEDPDICLEKLKHSG-AFQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSV 132

  Fly   143 HRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELHLANRKNPLESKI---LTDAVLERVEICFGAI 204
            |:.|:|||.||.|||.|||||.||||...:|..|...|...::...   |.:.|:.:....|.::
Human   133 HKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSRCPLNEEVIVQARKIFPSV 197

  Fly   205 LAFCVSYL------EIEPNASLQCLDGNVEGGQVDGAQYCTVLYNDESHTFDQVIQTLTKIAKCR 263
            :.:.|...      |:.|  .||..:.|        .:|..||:|||.|::|.||.:|.:...|.
Human   198 IKYVVEMTIWEEEKELPP--ELQIREKN--------ERYYCVLFNDEHHSYDHVIYSLQRALDCE 252

  Fly   264 AKDAMEIVAAIDREGRAVVKCDTFEECNKLKVSIENQMILPTSLVSTARNNQSLRTSVLHIGAVA 328
            ..:|.....|||:|||..||...:..|.:.|..|::.        |...:...|...|||...:|
Human   253 LAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSH--------SENVSQHPLHVEVLHSEIMA 309

  Fly   329 CQQFALQLLGWFQEFLVRHYLFRKTFSELVQRKQ---ETFC-IRHILEYDVKLWKTARTCWHRLL 389
            .|:|||:|..|..:.:.....||:.|.:...|::   |..| |..::.:|.||:|.||...|.|:
Human   310 HQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPDSENPCLISRLMLWDAKLYKGARKILHELI 374

  Fly   390 ISGMLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAHHLIAHEGIFD 454
            .|...||.:.|.:.|.||.:.|..:.:::||||||.:.||.:||||:||||::|.|||..:.:..
Human   375 FSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQMFTVPTLARHLIEEQNVIS 439

  Fly   455 KLLHTFYHVAIEKFIRNKTLHFSKNIASLTFFKRANYILYDLRYLLSLKPDVLSNDLRNGFLEGC 519
            .:..|...|..|...||...:|..  .|.....|...::.||:|:|..||.:.:..||..||||.
Human   440 VITETLLEVLPEYLDRNNKFNFQG--YSQDKLGRVYAVICDLKYILISKPTIWTERLRMQFLEGF 502

  Fly   520 RALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDWASGDVKLLRKLYKMT 584
            |:.:::|..|||||.:.||.|||::.:|:||.|..:.::|...:....:|.:.|.:||...||..
Human   503 RSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDEELLLVAYKEC 567

  Fly   585 MRALV--SNSFIVGGEKVMQPKKVADHVANCLVYDISVQPVSIHLPLSRFFAGIYL---HLGA-- 642
            .:|::  |.|||...:.|:|.   ..|......|.:|...|||||||||..||:::   .|||
Human   568 HKAVMRCSTSFISSSKTVVQS---CGHSLETKSYRVSEDLVSIHLPLSRTLAGLHVRLSRLGAVS 629

  Fly   643 --HD-LTYDGLQTETEALSIKLTPREIIE-PVLCTQAMIAQVGAGLWRRNGYTLLHQLYFYRNVR 703
              |: ::::..|.|.           ::| |:.|. .::|||.|.:|||||.:|:.|:::|::|:
Human   630 RLHEFVSFEDFQVEV-----------LVEYPLRCL-VLVAQVVAEMWRRNGLSLISQVFYYQDVK 682

  Fly   704 CRVEMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLSGNEMNDDIIRE-ASIFD 767
            ||.||.|:||..||||||||:.|:||:.||.|:.    |.|.:...:|..:  .|:|:: .::.:
Human   683 CREEMYDKDIIMLQIGASLMDPNKFLLLVLQRYE----LAEAFNKTISTKD--QDLIKQYNTLIE 741

  Fly   768 EFLELLIVIIGERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSDNVFEEVI 832
            |.|::||.|:|||::|||..||:|:...:|||.||||:|..||.:::.||:..  |::...|.||
Human   742 EMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENE--NNETGLENVI 804

  Fly   833 NTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQLVCCPPPML 897
            |.||.|||| |....||||||:..||:||||||||:|...||||.:|::|||.:.:....|||..
Human   805 NKVATFKKP-GVSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPP 868

  Fly   898 PKLTPAFTPMANILQCPVFLNICSLIMERALNAYSRSFTESHLQKVLHLLGYAIQEE------LS 956
            |:..|||:.:.|:|.|.:.:.|...:.|||::..|..:||..||...|:|...:.||      ..
Human   869 PEFCPAFSKVINLLNCDIMMYILRTVFERAIDTDSNLWTEGMLQMAFHILALGLLEEKQQLQKAP 933

  Fly   957 EHYPFLSFYERSQEYG--------ILEKLEELARCPRLEAHYDFVLWTIERF---KQLQAKQAPS 1010
            |......||.::...|        :||||:.:   |:||...|.:.|.::.|   |:|:.|
Human   934 EEEVTFDFYHKASRLGSSAMNIQMLLEKLKGI---PQLEGQKDMITWILQMFDTVKRLREK---- 991

  Fly  1011 DGRAGPSC-SQQGTGGKLSLSAEE----QAREERENRARLAAERRAHIMAQMQKAQKSFISSNAE 1070
                  || ....|.|..|:..:|    :.:.||:.:|..|...|..|||||...||:||.::..
Human   992 ------SCLIVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKL 1050

  Fly  1071 MFADTENETRKESASTGPMDWEDIPPEEEQGAVALESKVACLGPDRKFYHGTDDTFKCILCFENC 1135
            |:.:|.....||         :.|..||...||:..|::| |||.|.......:...||||.|..
Human  1051 MYDNTSEMPGKE---------DSIMEEESTPAVSDYSRIA-LGPKRGPSVTEKEVLTCILCQEEQ 1105

  Fly  1136 AISRGGRQLVSSAFVQTSRV------------------IFTTPNLRNSQSALHISCCGHVMHYSC 1182
            .:......:|.||.||.|..                  :|..|:|   ....:...||||||..|
Human  1106 EVKIENNAMVLSACVQKSTALTQHRGKPIELSGEALDPLFMDPDL---AYGTYTGSCGHVMHAVC 1167

  Fly  1183 WLEYFTNEEFKELRRPHRNRAALAQAANVEFQCPYCRTLSNAIIPVTETLPAFSAPPSPNESYLP 1247
            |.:||   |..:|....|....|....:.|:.||.|::|.|.:||:....|.
Human  1168 WQKYF---EAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIPLQPQ------------- 1216

  Fly  1248 LDSFVEIMSTLAIELGNVKDHELTTLPSVSNIL-RLSGVVGGLAQFERSVQLIKNPP------RL 1305
                 :|.|..|..|..:    ||....:..:| |:||.....|:.|..:.:..|..      ..
Human  1217 -----KINSENADALAQL----LTLARWIQTVLARISGYNIRHAKGENPIPIFFNQGMGDSTLEF 1272

  Fly  1306 HADYIEGIE--------FLKKALLNTMKIQQSHLKDHPAIESIEMVPIL-WDSCSYTLQALEIYL 1361
            |:....|:|        ..:..:|....|.:..|| .|..|....||:| |.:|::|:||:|..|
Human  1273 HSILSFGVESSIKYSNSIKEMVILFATTIYRIGLK-VPPDERDPRVPMLTWSTCAFTIQAIENLL 1336

  Fly  1362 YAVEKPLKAELSMRHQSCARNLVRACSRSSALEWETDLPLLPPMRSQAEFSSRLLDTIFNQNDTS 1426
            ....|||...|..|..:..:.|::     .|:......|.:...:......|.:|..|.:::...
Human  1337 GDEGKPLFGALQNRQHNGLKALMQ-----FAVAQRITCPQVLIQKHLVRLLSVVLPNIKSEDTPC 1396

  Fly  1427 VLEWDCFRVLVPFQFGVLNLMVPEKGYKTIIP------SGSMFDFYIMQTMFLAQLTKAVLCFDV 1485
            :|..|.|.|||    |.: |..|...:...:.      |.|....|:...:.:|.:.:.:|..|.
Human  1397 LLSIDLFHVLV----GAV-LAFPSLYWDDPVDLQPSSVSSSYNHLYLFHLITMAHMLQILLTVDT 1456

  Fly  1486 EKEKAKRAEKAPNSELTQLDYIEQLPSRIRDNMIDFYRRYNIPARVLQKTKQKQLVEEESEENQG 1550
            ....|:                                                 |:|:|||  .
Human  1457 GLPLAQ-------------------------------------------------VQEDSEE--A 1470

  Fly  1551 HGQTVVIPCESHHLALLLEY-----------------VQRQMSSFLRCSCLFYRFLTDVDFPDTF 1598
            |.       .|...|.:.:|                 ::..::.:|||:.||:.:|..|..|:..
Human  1471 HS-------ASSFFAEISQYTSGSIGCDIPGWYLWVSLKNGITPYLRCAALFFHYLLGVTPPEEL 1528

  Fly  1599 PTDQPD-RFDLMCQYLGLDPMLGVYFD--METVYATMMHSFASHPHIDREVEQR----CQPDARR 1656
            .|:..: .:..:|.||.|...|.:.|.  .:|| ..::..:.:.|.:...::|:    ..|..|.
Human  1529 HTNSAEGEYSALCSYLSLPTNLFLLFQEYWDTV-RPLLQRWCADPALLNCLKQKNTVVRYPRKRN 1592

  Fly  1657 SLQVEPCLRPLPRLKVLCDDFSDLINSVSDIFCPNNEREEMKTPTMCLICGLILCGQSYCCQPEL 1721
            || :|     ||      ||:|.|:|..|...||.:..:|.|.|.:||.||.|||.|:.|||..:
Human  1593 SL-IE-----LP------DDYSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQNICCQEIV 1645

  Fly  1722 GKVSVGACTHHAHACGAEVGIFLRIRDCQVVYL-GRGKGCFVPPPYLDEYGETDMGLRRGNPLRL 1785
            ....||||..||..|||.|.|||:||:|:||.: |:.:||..|.||||||||||.||:|||||.|
Human  1646 NGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHL 1710

  Fly  1786 SQAAYRKIYLQWLGHGLHGEIARLNDNANVAAAAQW 1821
            |:..|||::|.|..|.:..||||..:...:.....|
Human  1711 SRERYRKLHLVWQQHCIIEEIARSQETNQMLFGFNW 1746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ubr1	NP_001245723.1	zf-UBR	109..176	CDD:280386	43/66 (65%)
		ClpS	236..301	CDD:280736	24/64 (38%)
UBR1	NP_777576.1	zf-UBR	99..166	CDD:280386	43/66 (65%)
		ClpS	221..301	CDD:280736	27/95 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	842..868		11/25 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149946
Domainoid	1	1.000	732	1.000	Domainoid score	I105
eggNOG	1	0.900	-	-		E1_KOG1140
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	905	1.000	Inparanoid score	I374
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59210
OrthoDB	1	1.010	-	-		D34639at33208
OrthoFinder	1	1.000	-	-		FOG0001341
OrthoInspector	1	1.000	-	-		otm41728
orthoMCL	1	0.900	-	-		OOG6_101603
Panther	1	1.100	-	-	LDO	PTHR21497
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1593
SonicParanoid	1	1.000	-	-		X1260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800