DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ubr1 and UBR3

DIOPT Version :9

Sequence 1:	NP_001245723.1	Gene:	Ubr1 / 32687	FlyBaseID:	FBgn0030809	Length:	1824	Species:	Drosophila melanogaster
Sequence 2:	XP_005246356.1	Gene:	UBR3 / 130507	HGNCID:	30467	Length:	1903	Species:	Homo sapiens

Alignment Length:	2071	Identity:	417/2071 - (20%)
Similarity:	723/2071 - (34%)	Gaps:	622/2071 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GDNPSSALE------KLRLEG--------------NTATVCGKVFKNGEPTYSCRECGVDPTCVL 133
            |..|.:|.|      |..|.|              :.|.:||.|:......|.||.||:.|...|
Human    80 GGGPGAAEEEALEWCKCLLAGGGGYDEFCAAVRAYDPAALCGLVWTANFVAYRCRTCGISPCMSL 144

  Fly   134 CVNCFKRSAHRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELH-LANRKN----PLESKILTDAV 193
            |..||.:..|..|.:.|..|..||.|||||....::..:|:.| :.:..|    |.:..::::.|
Human   145 CAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVMRESGFCKRHQIKSSSNIPCVPKDLLMMSEFV 209

  Fly   194 LERVEICFGAILAFCVSYL-------------EIEPNASLQCLDGNVE--------GGQVDGAQY 237
            |.|...|.       :.||             |.:.|..||.|:..:.        ||.:... .
Human   210 LPRFIFCL-------IQYLREGYNEPAADGPSEKDLNKVLQLLEPQISFLEDLTKMGGAMRSV-L 266

  Fly   238 CTVLYNDESHTFDQVIQTLTKIAKCRAKDAMEIVAAIDREGRAVVKCDTFEECNKLKVSIENQMI 302
            ..||.|.::  :..:...|.:.| |..|...:.:.|:...|.      |:.| :||...::....
Human   267 TQVLTNQQN--YKDLTSGLGENA-CVKKSHEKYLIALKSSGL------TYPE-DKLVYGVQEPSA 321

  Fly   303 LPTSL------------------------------------VSTARNNQSLRTSVLHIGAVACQQ 331
            ..:||                                    :|:...:||:...:.|      :.
Human   322 GTSSLAVQGFIGATGTLGQVDSSDEDDQDGSQGLGKRKRVKLSSGTKDQSIMDVLKH------KS 380

  Fly   332 FALQLLGWFQEFLVRHYLFRKTFSELVQRKQETFCIRHILEYDVKLWKTARTCWHRLLISGMLME 396
            |..:||.|             |......:|..||.:                        .||.:
Human   381 FLEELLFW-------------TIKYEFPQKMVTFLL------------------------NMLPD 408

  Fly   397 YDNKMILAQEFSRRYATIVEDFISDDHDHAFS--IVSLSVQLFTVPSIAHHLIAHEGIFDKLLHT 459
            .:.|:...:.|.:.||.|::...........|  ||.:|||||:...:|..:.....:.|.::..
Human   409 QEYKVAFTKTFVQHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTV 473

  Fly   460 FYHVAIEKFIRNK------TLHFSKNIASLTFFKRANY--ILYDLRYLLSLKPDVLSNDLRNGFL 516
            ..::.....|:::      :||...|... ...|...|  ::.|...:||      ...:...||
Human   474 LLYMMESCLIKSELQDEENSLHVVVNCGE-ALLKNNTYWPLVSDFINILS------HQSVAKRFL 531

  Fly   517 EGCRAL---MRVLNVMQGMESMTRQTGQHMDYEPE-WECAFNLHIKLATTISQVIDWASGDVKLL 577
            |....|   |..::..|||....|:..:|:::|.: :..||...::...
Human   532 EDHGLLVTWMNFVSFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACA---------------- 580

  Fly   578 RKLYKMTMRALVSNSFIVGGEKVMQPKKVADHVAN-CL------------VYDISVQPVSIHLPL 629
                 ..|..|:|:.      ||.:.::...:|.. ||            |.:.:...|:.||||
Human   581 -----QPMWGLLSHC------KVRETQEYTRNVVRYCLEALQDWFDAINFVDEPAPNQVTFHLPL 634

  Fly   630 SRFFAGIYLH--LGAHDLTYDGLQTETEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNGYTL 692
            .|::| ::|.  :...:|..|.:..:.|.| :||    :|.| |..||.:|::.:.:|.|||..:
Human   635 HRYYA-MFLSKAVKCQELDLDSVLPDQEML-MKL----MIHP-LQIQASLAEIHSNMWVRNGLQI 692

  Fly   693 LHQLYFYRNVRCRVEMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLSGNEMND 757
            ..|...|........|:|.||..||:.||.::.:.|:..|..||..:..|      .::....|.
Human   693 KGQAMTYVQSHFCNSMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLL------TMASQHQNT 751

  Fly   758 --DIIREASIFDEFLELLIVIIGERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSELSRALPDGN 820
              |...|.|:.:..|..|::::..|...|:|   :::.||.|::..||:...:||.|...:|:..
Human   752 VLDAEHERSMLEGALTFLVILLSLRLHLGMS---DDEILRAEMVAQLCMNDRTHSSLLDLIPENP 813

  Fly   821 SGNSDNV-----FEEVINTVAVFKKPV----GADSKGVYELKEHLL-KEFN--------MYFYHY 867
            :..|..:     ||.|::.||.||.||    |:..:|:|..|..:. :||:        :|
Human   814 NPKSGIIPGSYSFESVLSAVADFKAPVFEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVY---- 874

  Fly   868 TKEDKSKAEELQRERRKAKKQLVCCPPPMLPKLT---PAFTPMANILQCP-----VFLNICSLIM 924
             :.|...|.:......|...:....|.|...|.|   |::..:..:|.|.     :|..:..::|
Human   875 -RRDVQSAMDRYTAFLKQSGKFPGNPWPPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILM 938

  Fly   925 ERALNAYSRSFTESHLQKVLHLLGYAIQEELSEH-----------------YP----------FL 962
            :.      ::.:|..|..||:|:...::....|.                 :|          |:
Human   939 DH------QNLSEHVLCMVLYLIELGLENSAEEESDEEASVGGPERCHDSWFPGSNLVSNMRHFI 997

  Fly   963 SFYE------------------RSQEYGILE---------------------------KLEEL-- 980
            ::..                  .|...|.|:                           |.:|:
Human   998 NYVRVRVPETAPEVKRDSPASTSSDNLGSLQSSRRPKVLQRENSGTAQVFSLVAERRKKFQEIIN 1062

  Fly   981 ---------------------ARCPR-----LEAHYDFVLWTIERFKQLQAKQ------------ 1007
                                 ...|:     ||.....:...|:...:|..||
Human  1063 RSSSEANQVVRPKTSSKWSAPGSAPQLTTAILEIKESILSLLIKLHHKLSGKQNSYYPPWLDDIE 1127

  Fly  1008 ----------APSDGRAG------PSCSQQGTGGKL---------------SLSAEEQAREEREN 1041
                      :..||...      .:.||.....::               .::|.|:...::|.
Human  1128 ILIQPEIPKYSHGDGITAVERILLKAASQSRMNKRIIEEICRKVTPPVPPKKVTAAEKKTLDKEE 1192

  Fly  1042 RARLAAERRAHIMAQMQKAQKSFISSNAEMFADT-ENETRKESASTGPMDWEDI----------P 1095
            |.:.|.||:..::|:....||||:.:  .|..|: ||:...|..:..|...|.:          |
Human  1193 RRQKARERQQKLLAEFASRQKSFMET--AMDVDSPENDIPMEITTAEPQVSEAVYDCVICGQSGP 1255

  Fly  1096 PEEEQ--GAVALESKVACLGPDR------KFYHGTDDTFKCILCFENCAISRGGR-QLVSSAFVQ 1151
            ..|::  |.|.|....:.||..|      |.....::.   |..::.||.....| .|:...|..
Human  1256 SSEDRPTGLVVLLQASSVLGQCRDNVEPKKLPISEEEQ---IYPWDTCAAVHDVRLSLLQRYFKD 1317

  Fly  1152 TSRVIFTTPNLRNSQSALHISCCGHVMHYSC---WLEYFTNEEFKELRRPHRNRAALAQAANV-- 1211
            :|.::..:...   :..:::..|||.:|..|   ::|...|::             :.|..:|
Human  1318 SSCLLAVSIGW---EGGVYVQTCGHTLHIDCHKSYMESLRNDQ-------------VLQGFSVDK 1366

  Fly  1212 -EFQCPYCRTLSNAIIPVTETLPAFSAPPSP-----NESYLPLDSFVEIMSTLAIELGNVKDHEL 1270
             ||.||.||..:|:::|   ..|..:...:|     |:|...|...||               ||
Human  1367 GEFTCPLCRQFANSVLP---CYPGSNVENNPWQRPSNKSIQDLIKEVE---------------EL 1413

  Fly  1271 TTLP-----SVSNILRLSGVVGGLAQFERSVQLIKN-PPRLHADYIEGIEFLKKALLNTMKIQQS 1329
            ...|     |:|:...||      .:.|..::.||| ..:.:.||.:.........|....:.::
Human  1414 QGRPGAFPVSISSETNLS------KEMESVMKDIKNTTQKKYRDYSKTPGSPDNDFLFMYSVART 1472

  Fly  1330 HLKDHPAIESIEMVPILWDSCS---------------YTLQALEIYLYAVEKPLKAELSMRHQSC 1379
            :|:       :|::....:.||               :.:.||.:.||:::.         ..:.
Human  1473 NLE-------LELIHRGGNLCSGGASTAGKRSCLNQLFHVLALHMRLYSIDS---------EYNP 1521

  Fly  1380 ARNLVRACSRSSALEWETDLPLLPPMRSQAEFSSRLLDTIFNQNDTSVLEWDCFRVLVPFQFGVL 1444
            .|.|.:....:..|.:|...|.:|               |...:.||:|       |:..
Human  1522 WRKLTQLEEMNPQLGYEEQQPEVP---------------ILYHDVTSLL-------LIQI----- 1559

  Fly  1445 NLMVPE---KGYKTIIPSGSMFDFYIMQTMFLAQLTKAVLCFDVEKEKAKRAEKAPNSELTQLDY 1506
             ||:|:   |.:.|.|..   ..|.::.|..||.|  :|.|.:.::...|.|
Human  1560 -LMMPQPLRKDHFTCIVK---VLFTLLYTQALAAL--SVKCSEEDRSAWKHA------------- 1605

  Fly  1507 IEQLPSRIRDNMIDFYRRYNI-PARVLQKTKQKQLVEEESEENQGHGQTVVIPCESHHLALLLEY 1570
                 ..::.:..|..:.|.: .:.|:.:..:.:|..||..:.......:....||....|
Human  1606 -----GALKKSTCDAEKSYEVLLSFVISELFKGKLYHEEGTQECAMVNPIAWSPESMEKCL---- 1661

  Fly  1571 VQRQMSSFLRCSCLFYRFLTDVDFPDTFPTDQPDRFDLMCQYLGLDPMLGVYFDMETVYATMMHS 1635
             |.....|||.:.|....|...|.|.   ..:.:.|.::...|||.|         |.|.| .|.
Human  1662 -QDFCLPFLRITSLLQHHLFGEDLPS---CQEEEEFSVLASCLGLLP---------TFYQT-EHP 1712

  Fly  1636 FASHPHIDREV------EQRC---------QPDARRSLQVEPCLRPLPRLKVLCDDFSDLINSVS 1685
            |.|...:|..|      .|.|         ..:..::|.::.....||.|..|.::::.:.....
Human  1713 FISASCLDWPVPAFDIITQWCFEIKSFTERHAEQGKALLIQESKWKLPHLLQLPENYNTIFQYYH 1777

  Fly  1686 DIFC------PNNEREEMKTPTMCLICGLILCGQSYCCQPELGKVSVGACTHHAHACGAEVGIFL 1744
            ...|      |       |.|.:||:||..:|.:..||:.:    |...|..|:..|||..||||
Human  1778 RKTCSVCTKVP-------KDPAVCLVCGTFVCLKGLCCKQQ----SYCECVLHSQNCGAGTGIFL 1831

  Fly  1745 RIRDCQVVYLGRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWLGH 1800
            .|....::.:...:.|.....|||.:||.|..||||.||.:.:..|:.:..||:.|
Human  1832 LINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYICKERYKVLEQQWISH 1887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubr1	NP_001245723.1	zf-UBR	109..176	CDD:280386	25/66 (38%)
Ubr1	NP_001245723.1	ClpS	236..301	CDD:280736	13/64 (20%)
UBR3	XP_005246356.1	zf-UBR	120..187	CDD:280386	25/66 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D34639at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920