DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ubr1 and ubr1

DIOPT Version :9

Sequence 1:	NP_001245723.1	Gene:	Ubr1 / 32687	FlyBaseID:	FBgn0030809	Length:	1824	Species:	Drosophila melanogaster
Sequence 2:	XP_002941132.3	Gene:	ubr1 / 100490039	XenbaseID:	XB-GENE-6052364	Length:	1749	Species:	Xenopus tropicalis

Alignment Length:	1828	Identity:	564/1828 - (30%)
Similarity:	873/1828 - (47%)	Gaps:	245/1828 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 KESLAKEEIIDVVVEFMLGDNPSSALEKLRLEGNTATVCGKVFKNGEPTYSCRECGVDPTCVLCV 135
            :|.||::.|:..:...:..::|:...|||| ......:||:||:.||.|||||:|.:|||||||:
Frog    57 QEELAQKLILTPLEWCLFREDPNVFKEKLR-HSAAPPLCGRVFRGGETTYSCRDCAIDPTCVLCM 120

  Fly   136 NCFKRSAHRFHKYKMSTSGGGGCCDCGDDEAWKKDQYCELHLANRKNPLESKILTDAVLERVEIC 200
            :||:.|.|:.|:|||.:|.|||.|||||.||||...||::|.....:......|.|.:|.:.:|.
Frog   121 DCFQNSIHKNHRYKMHSSMGGGFCDCGDTEAWKTGPYCKIHEPGPSDQNSDFRLKDELLAQTKIV 185

  Fly   201 FGAILAFCVSYLEIEPNASLQCLDGNVEGGQVDGAQYCTVLYNDESHTFDQVIQTLTKIAKCRAK 265
            |..|:.:.|..|..|...||...   ::.|.|:..||..||||||.||:|..|.:|.:...|..|
Frog   186 FPLIIRYIVDMLIWEEQKSLPAY---LDTGTVEWNQYYCVLYNDEHHTYDHFIYSLQRSLGCDQK 247

  Fly   266 DAMEIVAAIDREGRAVVKCDTFEECNK----LKVSIENQMILPTSLVSTARNNQSLRTSVLHIGA 326
            :|..:.:|.:||||..||..|.|:|.:    ||.:.||..:.|            :...|||...
Frog   248 EAQTLTSAAEREGRKAVKKGTLEQCQEVTESLKANSENVSLKP------------VHVEVLHGHV 300

  Fly   327 VACQQFALQLLGWFQEFLVRHYLFRKTFSELVQRKQ-------ETFCIRHILEYDVKLWKTARTC 384
            :|.|.|||.|..|..:.|.....||:.|.::...::       .|..:..::..|.||.|..|..
Frog   301 MAHQSFALCLAIWLNKLLAYSSDFRQIFCQVCLEQEPKPSSFNHTCYVSLLILKDSKLHKGVRKV 365

  Fly   385 WHRLLISGMLMEYDNKMILAQEFSRRYATIVEDFISDDHDHAFSIVSLSVQLFTVPSIAHHLIAH 449
            .|.|:.|...||.:.|...|.||.:.|..|.:::|:||.|...|:.::|||:||||::|..||..
Frog   366 LHDLIFSSFFMEMEYKKQFAIEFVKHYKQIQKEYINDDQDRNISVTAISVQVFTVPTLARLLIEE 430

  Fly   450 EGIFDKLLHTFYHVAIEKFIRNKTLHFSKNIASLTFFKRANYILYDLRYLLSLKPDVLSNDLRNG 514
            :.:...:..|...|..|....:...:|........|...|  |:.||:|:|..||...|..|:..
Frog   431 QNVMKVITETLLEVIKEYLGSDNKFNFQGYSQERFFMVYA--IILDLKYILISKPTSWSEKLKAK 493

  Fly   515 FLEGCRALMRVLNVMQGMESMTRQTGQHMDYEPEWECAFNLHIKLATTISQVIDWASGDVKLLRK 579
            ||||.::.:..|:.|||||.::|..|||::.:.:||....:.::|...::.:.:|.:.|..:|.|
Frog   494 FLEGFKSFLYFLSCMQGMEGISRMVGQHVEMDSDWEAVIAMQMQLKNVLTLIQEWCATDDDILLK 558

  Fly   580 LYKMTMRALVSNSFIVGGE--KVMQPKKVADHVANCLVYDISVQPVSIHLPLSRFFAGIYLHLGA 642
            .||....:|:.....|..:  |::   |::.|......|.:|..|:||||||||..||::.
Frog   559 SYKECHLSLLQCCTPVPSQEKKLI---KMSGHSYQSYPYMVSKDPISIHLPLSRMLAGLHA---- 616

  Fly   643 HDLTYDGLQTE------TEALSIKLTPREIIEPVLCTQAMIAQVGAGLWRRNGYTLLHQLYFYRN 701
             .:...|:.|.      .|.|.::|.   |..|:.|. .::.||.|.:|||||.|::.|:::|.:
Frog   617 -QMCRTGVITRLCEILPPEDLQVELM---IEHPLRCL-VLVGQVAAEMWRRNGLTIVSQVFYYHD 676

  Fly   702 VRCRVEMLDRDIACLQIGASLMESNEFLIHVLNRFNTIPWLQENYWSLLSGNEMNDDIIREASI- 765
            |:||.||.|:|:..||||||.::.|.||:.:|.|:..     |..:|.::....:.|:.|:.:|
Frog   677 VKCREEMYDKDVVMLQIGASYLDPNSFLLLLLQRYEL-----EEAFSNVAVPTKDMDVARQHNIL 736

  Fly   766 FDEFLELLIVIIGERWMPGVSMVTEEDRLRKEIIQLLCIKPYSHSELSRALPDGNSGNSDNVFEE 830
            .:|.|.:||.:||||::||:|.||.|:...:|||.||||:|.:||.:::|||:  :.|:|...::
Frog   737 IEEMLHVLICVIGERYVPGISNVTREECTMREIIHLLCIEPMAHSAIAKALPE--TENTDICLDK 799

  Fly   831 VINTVAVFKKPVGADSKGVYELKEHLLKEFNMYFYHYTKEDKSKAEELQRERRKAKKQLVCCPPP 895
            :|:.||.|||| |....||||||...|.:||::||||||...||||..|::|||.:.......||
Frog   800 LISKVATFKKP-GVSGHGVYELKAEYLDQFNVFFYHYTKTQHSKAEHTQKKRRKQENSSEALAPP 863

  Fly   896 MLPKLTPAFTPMANILQCPVFLNICSLIMERALNAYSRSFTESHLQKVLHLLGYAIQEE------ 954
            ..|..:|||..:..:|.|.:.::|...|::||.......:||..:|.|||::...:.||
Frog   864 APPNFSPAFCNVTKLLCCDIMMHILRTILKRAAEEDPIMWTEGMIQMVLHIIALGLLEEKQQLQR 928

  Fly   955 LSEHYPFLSFYER--------SQEYGILEKLEELARCPRLEAHYDFVLW------TIERFKQLQA 1005
            .:|.....:||.:        :....:...||.|....:|:|..|.::|      |::..::..:
Frog   929 AAEEEVTFNFYHKATRVRSTDANAQSVATLLERLKGITQLDAQKDMIIWVRQVFETVKGLRETSS 993

  Fly  1006 KQAPSDGRAGPSCSQQGTGGKLSLSAEEQAREERENRARLAAERRAH---IMAQMQKAQKSFISS 1067
            ...|:|           |...::.:.|.|:.:|:|.|.|.|...|.|   |||||...||:||.:
Frog   994 HTVPTD-----------TVSDVAKAEEGQSPQEKEKRKRKAEAARLHRQKIMAQMSALQKNFIET 1047

  Fly  1068 NAEMFADTENETRKESASTGPMDWEDIPPEEEQGAVALESKVACLGPDRKFYHGTDDTFKCILCF 1132
            | ::..||..|.::   ||.|:: |.:...:|...|||.:|.....|.:       |...||||.
Frog  1048 N-KLLYDTTVEVQE---STSPVE-ESLLSADEGSKVALGTKRGPTVPSK-------DVLTCILCQ 1100

  Fly  1133 ENCAISRGGRQLVSSAFVQTSRV------------------IFTTPNLRNSQSALHISCCGHVMH 1179
            |...:......:|.:|.||.|..                  :||.|.:   ....|...||||||
Frog  1101 EEQEVKLDKPTMVLTACVQKSTTLSQTRSKVVSHTGETFDPLFTHPEM---LYGTHTGSCGHVMH 1162

  Fly  1180 YSCWLEYFTNEEFKELRRPHRNRAALAQAANVEFQCPYCRTLSNAIIP----VTETLPAFSAPPS 1240
            ..||.::|  |..::..|...:...:....|.|:.||.|:...|.:||    |.:.:.:..|.
Frog  1163 VVCWQKFF--EAMQKNTRQRLHVELIFDLGNGEYLCPLCKCHCNTVIPIIPHVAQQIQSVDAE-- 1223

  Fly  1241 PNESYLPLDSFVEIMSTLAIELGNVKDHELTTLPSVSNILRLSGVVGGLAQFE-RSVQL--IKNP 1302
                  .::....:...|.|....:..:.|.|:.....|......:.....:| ||:..  ::.|
Frog  1224 ------AINCVFSLPHWLDIVAARISGYNLNTIKGTKPITPEFCKIYKDQNYEFRSILSFGVQAP 1282

  Fly  1303 PRLHADYIEG--IEF---LKKALLNTMKIQQSHLKDHPAIESIEMVPIL-WDSCSYTLQALEIYL 1361
            || :....||  :.|   :.:..||.           |..||...:|:: |::|::|:|.:|.:|
Frog  1283 PR-YPTCTEGMLVHFATTVYRVGLNV-----------PPNESDSRMPVMTWNTCAFTIQCIESWL 1335

  Fly  1362 YAVEKPLKAELSMRHQSCARNLVRACSRSSALEWETDLPLLPPMRSQAEFSSRLLDTIFNQNDTS 1426
            ...||||...|..|..:..:.||:.   :.|.......||:  .|......:..|..|..::..|
Frog  1336 QDEEKPLFGSLQNRQLAGLQALVKF---AEAQRVTCPQPLI--RRHLIRLLAAFLPNITLEDTPS 1395

  Fly  1427 VLEWDCFRVLVPFQFGVLNLMVPEK---GYKTIIPS-GSMFDFYIMQTMFLAQLTKAVLCFDVEK 1487
            .|..|.|.:||.......:|...|.   ...|::.: .:::.|:::....:.|:..::...:|..
Frog  1396 FLSLDVFHLLVGSVLAFPSLYCEENVDLHPSTLVSTYNNLYLFHLLTMTHILQIIFSLTTDNVPS 1460

  Fly  1488 EKAKRAEKAPNSELTQLDYIEQLPSRIRDNMIDFYRRYNIPARVLQKTKQKQLVEEESEENQGHG 1552
            .:....|:| .:..|....|.||.|  ....|||...|
Frog  1461 TEPDDCEEA-RTAATLCQDISQLTS--NSLKIDFPGWY--------------------------- 1495

  Fly  1553 QTVVIPCESHHLALLLEYVQRQMSSFLRCSCLFYRFLTDVDFPDTF----PTDQPDRFDLMCQYL 1613
               |..|           |:..:..:|||:.||:.:|..|..|:..    .||  ::...:|.:|
Frog  1496 ---VWKC-----------VKEGIMPYLRCAALFFHYLLGVMPPEELKSSGTTD--NQLSALCSFL 1544

  Fly  1614 GLDPMLGVYFDMETVYATMMHSFASHPHIDREVEQRCQPDARRSLQ-----VEPCLRPLPR---- 1669
            .|.             ..::..|..:..|.:.:.||...|  :|||     ....|| .||
Frog  1545 CLP-------------TNILLLFQENWDIVKLLIQRLSSD--QSLQSVLAGYTTALR-YPRKRNT 1593

  Fly  1670 LKVLCDDFSDLINSVSDIFCPNNEREEMKTPTMCLICGLILCGQSYCCQPELGKVSVGACTHHAH 1734
            |..|.:|:|.|:|..|...||..:..|.|.|.|||:||.|||.|:.|||..:....:||||.||.
Frog  1594 LIELPEDYSSLLNQASQFRCPKFQDAERKHPVMCLLCGAILCSQNTCCQEVVNGEELGACTAHAM 1658

  Fly  1735 ACGAEVGIFLRIRDCQVVYL-GRGKGCFVPPPYLDEYGETDMGLRRGNPLRLSQAAYRKIYLQWL 1798
            .|||.|.|||.||:|:||.: |:.:||....||||||||||.||:|||||.||...|||::..|.
Frog  1659 HCGAGVCIFLSIRECKVVLMEGKTRGCIYQAPYLDEYGETDPGLKRGNPLHLSHERYRKLHQLWQ 1723

  Fly  1799 GHGLHGEI 1806
            .|.:..||
Frog  1724 QHCIIEEI 1731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ubr1	NP_001245723.1	zf-UBR	109..176	CDD:280386	42/66 (64%)
Ubr1	NP_001245723.1	ClpS	236..301	CDD:280736	30/68 (44%)
ubr1	XP_002941132.3	zf-UBR	94..161	CDD:396677	42/66 (64%)
		ClpS	217..>274	CDD:396950	26/56 (46%)
		RING-H2_UBR1	1092..1211	CDD:319599	34/123 (28%)
		PRT6_C	1296..1724	CDD:408765	146/505 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	729	1.000	Domainoid score	I110
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	905	1.000	Inparanoid score	I368
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D34639at33208
OrthoFinder	1	1.000	-	-		FOG0001341
OrthoInspector	1	1.000	-	-		otm48950
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060