DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and AGE2

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_012220.3	Gene:	AGE2 / 854767	SGDID:	S000001306	Length:	298	Species:	Saccharomyces cerevisiae

Alignment Length:	228	Identity:	52/228 - (22%)
Similarity:	85/228 - (37%)	Gaps:	35/228 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 NNIKKLNINAENLHGNCAEKKL--PSSGQN-------------KLILQENNSDSQQPI-YGPDAN 88
            ||::..:.....|.....::|:  .||.||             .|...|..:||.:|: :.|.||
Yeast    82 NNLRANSYYEATLADELKQRKITDTSSLQNFIKNKYEYKKWIGDLSSIEGLNDSTEPVLHKPSAN 146

  Fly    89 ENVQEPVYATPRPAPRQRLPPAGEPEDSYPDPDDEVPLRILRAAPQIPPKPLNILLDQRSSICSE 153
            .::         ||...||   .:..:|......:.|..:| :..:.....||:.:...|...|.
Yeast   147 HSL---------PASNARL---DQSSNSLQKTQTQPPSHLL-STSRSNTSLLNLQVSSLSKTTSN 198

  Fly   154 VSTTSVQTPGKADEDREGSR---YASNASLDCSESSHSGKFKSQSPGYVDAVDSSIPQ-SDHPDP 214
            .|.||..|...|...:.|:|   :.....|..|..|...|..:|:........|:.|| .:.|.|
Yeast   199 TSVTSSATSIGAANTKTGNRVGEFGQRNDLKKSILSLYSKPSAQTQSQNSFFTSTTPQPCNTPSP 263

  Fly   215 --NGHHPQAESSSAEQSSGSQDGDDDNNLLRSL 245
              |.......::|...:|.|....|||.|.:::
Yeast   264 FVNTGITATNNNSMNSNSSSNISLDDNELFKNV 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
AGE2	NP_012220.3	COG5347	1..298	CDD:227651	52/228 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900