DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and GTS1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_011334.1	Gene:	GTS1 / 852694	SGDID:	S000003149	Length:	396	Species:	Saccharomyces cerevisiae

Alignment Length:	286	Identity:	52/286 - (18%)
Similarity:	97/286 - (33%)	Gaps:	65/286 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 PQAESSSAEQSSGSQDGDDDNNLLRSLGTTSKLL------GEAIGERITFKAKGAK--KRL---- 271
            |:...|..:...|..|..|:.|..||...:....      .:..|.|.:|::.|::  ::|
Yeast   139 PEDFGSRMDDFDGESDRFDERNRSRSRSRSHSFYKGGHNRSDYGGSRDSFQSSGSRYSRQLAELK 203

  Fly   272 DRNF---KSSTEAISNIGADAGRSLKHASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQ 333
            |..|   ..:.:|:|:...:..|::.:..|.     |..||...|.......|       |.||:
Yeast   204 DMGFGDTNKNLDALSSAHGNINRAIDYLEKS-----SSSRNSVSAAATTSTPP-------LPRRR 256

  Fly   334 TM---PSTEVFNTIQFSSPLNRNGGLPDLRENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKPPS 395
            ..   |...:|:        ..|...||...|.|..                      .|.||..
Yeast   257 ATTSGPQPAIFD--------GTNVITPDFTSNSASF----------------------VQAKPAV 291

  Fly   396 YDEALRSRPSPSDSPMSRNLAQEAAQLVQLRNQRQ-----LSSSSSNGDESPRLPMPAFPPPRLS 455
            :|..|:....|:...:..:..|.|..:.|.:.|:|     .:.:.:......::...|....:..
Yeast   292 FDGTLQQYYDPATGMIYVDQQQYAMAMQQQQQQQQQLAVAQAQAQAQAQAQAQVQAQAQAQAQAQ 356

  Fly   456 QQPEQFRMDALQPPVRQKRRKNYEHI 481
            .|.:|.:|..||...:|:...:::.:
Yeast   357 AQAQQIQMQQLQMQQQQQAPLSFQQM 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
GTS1	NP_011334.1	COG5347	8..310	CDD:227651	40/212 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3385
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930