DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and smap1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_021336343.1	Gene:	smap1 / 777731	ZFINID:	ZDB-GENE-060920-2	Length:	483	Species:	Danio rerio

Alignment Length:	375	Identity:	75/375 - (20%)
Similarity:	138/375 - (36%)	Gaps:	105/375 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 PEQFRMDALQPPVRQKRRKNYE-HI--ELRRPPVDSA------------QLEELNRAAAAAEREE 507
            |||  :.::|.....|.|:.|| |:  ..|||..|.|            :..:.|....|.:..:
Zfish    80 PEQ--IQSVQSMGNTKARQLYEAHLPENFRRPQTDQAVEFFIRDKYERKKYYDKNSVNGAIKSSD 142

  Fly   508 SLL--ISAKNAEAETKTP-KPERSDSWEFYGEDENEEEDRDEEQEGSSSPEPLYANQE------- 562
            :.|  :|:.:::|..|:. :.||        |.:.||:.|:::.:..:.|..|...:|
Zfish   143 AALPSVSSPSSQAAEKSKLEKER--------EKKKEEKKREKDTDKENKPAVLEKKREDNQIDSR 199

  Fly   563 ATYGKLFEMA---------TAGSSRSNVLTPNQVAEQQQLACITEDSELDACEGAVGGVPLPQAV 618
            .:..|..|.|         |.||:.|.       |.....|.|::|.::   .|.:...||| :.
Zfish   200 ISPKKSAEPAIDLLGLDAPTVGSASSG-------AGTSSAAPISDDLDI---FGPMVSNPLP-SN 253

  Fly   619 IEEFDPLSSKCSTLARSNKSNELLLLEHLLEEDTYGTVKA--EQDDVSMCTSEEEPTTSAATSPK 681
            .......|||.:..|:::.:...:       ....||..|  .|.|:.:.:.....:.:..::.|
Zfish   254 SNSSQVSSSKAAGSAQASSAGGAV-------AGATGTGSAAPAQGDLDLFSETSGNSKAEDSAKK 311

  Fly   682 PQQPQIVHQNARLLSDSMENMLDSDQERAKPYLSRMPESANKAS----GPVDLASASRNRTNWFV 742
            |           |..||:.::..|         |.:|:...:|:    ||..:...::.:.|:
Zfish   312 P-----------LSKDSILSLYGS---------STVPQQPAQATAMFMGPSQMQFPAQPQGNF-- 354

  Fly   743 PDKASCSDVTPNTSKTTPPIEGDSPP-TYLEAIGGSKDAAGNQENRSTIG 791
                          :..|.:.|..|| |.:.|:.|...|...|.....:|
Zfish   355 --------------QAFPGMGGAMPPTTMMGAVMGQGGAMMGQNTGMMVG 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
smap1	XP_021336343.1	ArfGap	18..132	CDD:307528	14/53 (26%)
smap1	XP_021336343.1	Med15	<329..>466	CDD:312941	14/78 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900