DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and Arfgap2

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_001159496.1	Gene:	Arfgap2 / 77038	MGIID:	1924288	Length:	534	Species:	Mus musculus

Alignment Length:	458	Identity:	101/458 - (22%)
Similarity:	166/458 - (36%)	Gaps:	114/458 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 SRYASNASLDCSES--SHSGKFK--------SQSPGYVDAVDSSIPQSDHPDPNGHHPQAESSSA 226
            :|:.::..:|...|  |||.:.|        :|:|.:..|.         .||:|  .|..:..:
Mouse   127 TRHGTDLWIDSMNSAPSHSPEKKDSDFFTEHTQAPAWDTAA---------TDPSG--TQQPALPS 180

  Fly   227 EQSSGSQDGDDDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGADAGR 291
            |.||.:|.....|..|  |||:.    :|..|.:...|||..  ..|..|||.         .|:
Mouse   181 ESSSLAQPEQGPNTDL--LGTSP----QASLESMYLSAKGPS--CTRELKSSI---------IGK 228

  Fly   292 SLKHASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLNRNGGL 356
            ....|:|:                |:|.:.|    :...:......||:....|.:..|.
Mouse   229 KKPAAAKK----------------GLGAKKG----LGAQKVSNQSFTEIERQAQVAEKLR----- 268

  Fly   357 PDLRENDAKLQKED-----------YLRPDPDQEDDGCYEVPKTQGKPPSYDE----ALRSRPSP 406
             :.:..|||.|.|:           .|:.|..:|:.   ::...:||.....|    .|.||.|.
Mouse   269 -EQQAADAKKQAEESMVASMRLAYQELQIDRKKEEK---KLQNLEGKKREQAERLGMGLVSRSSI 329

  Fly   407 SDSPMSRNLAQEAAQLVQLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQP----EQF--RMDA 465
            |.|.:|.      .|:::........||.|..|....:...|..||:....|    |.|  |.|:
Mouse   330 SHSVLSE------MQMIEQETPLSAKSSRSQLDLFDDVGTFASGPPKYKDNPFSLGETFGSRWDS 388

  Fly   466 LQPPVRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPERSDS 530
                   ......:.:|.:.|.|..:.:..::...|:....|:.....:::||..|....:...|
Mouse   389 -------DAAWGMDRVEEKEPEVTISSIRPISERTASRREVETRSSGLESSEARQKFAGAKAISS 446

  Fly   531 WEFYG---EDENEEEDRDEEQEGSS--SPEPLYANQEATYGKLFEMATAGS-SRSNVLTPNQVAE 589
            ..|:|   :.|.|...|.::..|||  |...|:.|.:..:|       .|: |..|||....:|:
Mouse   447 DMFFGREVDSEYEARSRLQQLSGSSAISSSDLFGNMDGAHG-------GGTVSLGNVLPTADIAQ 504

  Fly   590 QQQ 592
            .:|
Mouse   505 FKQ 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Arfgap2	NP_001159496.1	PLN03114	3..484	CDD:178661	93/426 (22%)
Arfgap2	NP_001159496.1	ArfGap	11..117	CDD:279720
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900