DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and Appl1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_660256.1	Gene:	Appl1 / 72993	MGIID:	1920243	Length:	707	Species:	Mus musculus

Alignment Length:	875	Identity:	161/875 - (18%)
Similarity:	263/875 - (30%)	Gaps:	362/875 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 DDDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIG----------ADA- 289
            |..|.|..:...|||||.|.  |:..|...|..:.:....:..::.|..:.          |||
Mouse    49 DAQNELSAATHLTSKLLKEY--EKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAM 111

  Fly   290 --------GRSLKH-----------------ASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDL 329
                    .|.||.                 |..|: |..|..|..||....:      :.::..
Mouse   112 MFPISQFKERDLKEILTLKEVFQIASNDHDAAINRY-SRLSKKRENDKVKYEV------TEDVYT 169

  Fly   330 DRR---QTMPSTEVF---NTIQFS------SPL----------------NRNGGLPDL------- 359
            .|:   |||  ...|   ||:|:.      .||                |.||.|.:.
Mouse   170 SRKKQHQTM--MHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNGQLEEFLANIGTS 232

  Fly   360 -----RENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKPPSYDEALRSRPSPSDSPMSRNLAQEA 419
                 ||.|..::.......|.:...|..| :|.               |.|:..|::|||.::|
Mouse   233 VQNVRREMDGDVETMQQTIEDLEVASDPLY-LPD---------------PDPTKFPINRNLTRKA 281

  Fly   420 AQLVQLRNQRQLSSSS----------------SNGDESPRLPMPAFPPPRLSQQPEQFR------ 462
            ..| ..||:..|.||:                :.||.:..|.|.......::...|..|
Mouse   282 GYL-NARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQIT 345

  Fly   463 -MDALQPPVRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPE 526
             .|..:..:.|...|. :|.|.      ...:..:::....:|..|........:..|..||.|
Mouse   346 SFDGKKSSILQAESKK-DHEEW------ICTINNISKQIYLSENPEETAARVNQSALEAVTPSP- 402

  Fly   527 RSDSWEFYGEDENEEEDRDEEQEGSSSPEPLYANQEATYGKLFEMATAGSSRSNVLTPNQVAEQQ 591
                        :.::..:..:.|..|..|                ||.:|.|..|.    :|..
Mouse   403 ------------SFQQRHESLRPGGQSRPP----------------TARTSSSGSLG----SEST 435

  Fly   592 QLACITEDSELDACEGAVGGVPLPQAVIEEFDPLSSKC-------------------------ST 631
            .||.::.||           :..|...| :||.:|..|                         ||
Mouse   436 NLAALSLDS-----------LVAPDTPI-QFDIISPVCEDQPGQAKAFGQGGRRTNPFGESGGST 488

  Fly   632 LARSNKS--NELLLLEHLLEEDTYGTVKAEQDDVSMCTSEEEPTTSAATSPKPQQPQIVHQNAR- 693
            .:.:..|  ::|.::..|      |:::.:.||                     .|.:|::..|
Mouse   489 KSETEDSILHQLFIVRFL------GSMEVKSDD---------------------HPDVVYETMRQ 526

  Fly   694 -LLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSD-VTPNTS 756
             |.:.::.|:.            ||.||....:                    ..|.. :.|.|.
Mouse   527 ILAARAIHNIF------------RMTESHLLVT--------------------CDCLKLIDPQTQ 559

  Fly   757 KT--TPPIEGDSPPTYLEAIGGSKDAAGNQENR-------STIGSRFRQTINAISNVKLKMDAMK 812
            .|  |.|:    |...|.|.        :|||:       .|.|.|....::::..:
Mouse   560 VTRLTFPL----PCVVLYAT--------HQENKRLFGFVLRTSGGRSESNLSSVCYI-------- 604

  Fly   813 RKASFRGANQRQ---SDVRVALQMVPRPSLSPLLIRYEGPLVRFPSGVVEDI--LKEMQNRKAIL 872
                |...|:.:   ..|.:|.|           |.....|.|..|...::|  :||.| :|.:.
Mouse   605 ----FESNNEGEKICDSVGLAKQ-----------IALHAELDRRASEKQKEIERVKEKQ-QKELS 653

  Fly   873 RERQFQTFLDQEMKTPREMIPLDTITTLQCVSNSRVTDTATHFYCFEITTSQPKNGNGAGDAMSS 937
            :::|.:..|:::                     ||:.          ..:|:|   |.||    |
Mouse   654 KQKQIEKDLEEQ---------------------SRLI----------AASSRP---NQAG----S 680

  Fly   938 NPNLLMTSSSSGNVKQQRVSHLYGVGKESE 967
            ...|:::||      |...|.|...||:.|
Mouse   681 EGQLVLSSS------QSEESDLGEEGKKRE 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Appl1	NP_660256.1	Required for RAB5A binding. /evidence=ECO:0000250	1..428		83/442 (19%)
		BAR_APPL1	20..234	CDD:153315	40/195 (21%)
		BAR-PH_APPL	252..376	CDD:270067	28/147 (19%)
		PH	280..375	CDD:278594	18/102 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..433		11/68 (16%)
		F&H. /evidence=ECO:0000250	403..414		0/10 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..490		2/23 (9%)
		PTB_APPL	489..624	CDD:269980	35/228 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..707		24/114 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810