DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGAP15B and AGAP5

DIOPT Version :9

Sequence 1:NP_573183.2 Gene:RhoGAP15B / 32686 FlyBaseID:FBgn0030808 Length:1552 Species:Drosophila melanogaster
Sequence 2:NP_001137472.1 Gene:AGAP5 / 729092 HGNCID:23467 Length:686 Species:Homo sapiens


Alignment Length:798 Identity:151/798 - (18%)
Similarity:258/798 - (32%) Gaps:280/798 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   535 GEDENEEEDRDEEQEGSSSPE----PLYANQEATYGKLFEMATAGSSRSNVLTPNQVAEQQQLAC 595
            |||.:....||:|.     ||    .|.||.||:  .:|:.    :|:::.|..|..|..:....
Human    59 GEDLHMHHIRDQEM-----PEALEFSLSANPEAS--TIFQR----NSQTDALEFNPSANPEASTI 112

  Fly   596 ITEDSELDA-------CEGAVGGVPLPQAVIEEFDPLSSKCST--LARSNKSNELLLL------- 644
            ...:|:.|.       |...|.        .|.|....|.|||  |..|..|...|.:       
Human   113 FQRNSQTDVVEIRRSNCTNHVS--------TERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTL 169

  Fly   645 ---EHLLEEDTYGTVKAEQDDVSMCTSEEEPTTSAATSPKPQQPQIVHQNARLLSDSMENMLDSD 706
               .|:.:.|.         |.|:...:|:..:.|.::....:.:....:....|.|:.:...:.
Human   170 EIPHHITQRDA---------DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTS 225

  Fly   707 QERAKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNTSKTTPPIEGDSPPTYL 771
            ||  .|..| :|.:||.   |..:...|...:|.|..:|.|           .|..|..:|..:.
Human   226 QE--DPQFS-VPPTANT---PTPVCKRSMRWSNLFTSEKGS-----------HPDKERKAPENHA 273

  Fly   772 EAIGGSKDAAGNQENRSTIGSRFRQTINAISNVKLKMDAMKRKASFRGANQRQSDVRVALQMVPR 836
            :.||..:                     ||. :|..| .:||...:....:::.           
Human   274 DTIGSGR---------------------AIP-IKQGM-LLKRSGKWLKTWKKKY----------- 304

  Fly   837 PSLSPLLIRYEGPLVRFPSGVVEDILKEMQNRKAILRERQFQTFLDQEMKTPREMIPLDTITTLQ 901
                 :.:...|.|..:.|  :.|.:|.:..::..||        ...:|.|.:...|.|..   
Human   305 -----VTLCSNGVLTYYSS--LGDYMKNIHKKEIDLR--------TSTIKVPGKWPSLATSA--- 351

  Fly   902 CVSNSRVTDTATHFYCFEITTSQPKNG------NGAGDAMSSNPNLLMTSSSSGN---------- 950
                           |..|::|: .||      .|.||::..:|::..|:|...|          
Human   352 ---------------CAPISSSK-SNGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKK 400

  Fly   951 --VKQQRVSHLYGVGKE-----------SERGVWMQKILESLTNSLPVKYTCHYYRAGWCYLKNS 1002
              :|::..::...|...           .||..|:|.|...:..||   .:|...::     |:.
Human   401 KHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASL---QSCESSKS-----KSQ 457

  Fly  1003 ITSEWSGTWLVLRKSQRRLIFVSEANGNVEKMDLR-KARCIVLKESDESIDNLHVESGPMLMIDC 1066
            :||:                  |||.......::| .|.|:..:..:....:|::  |.::.|:|
Human   458 LTSQ------------------SEAMALQSIQNMRGNAHCVDYETQNPKWASLNL--GVLMCIEC 502

  Fly  1067 PPYAVYMIMSSARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIY 1131
                          :.|.|.:...::......|.|.       ||.:.|.::  .|...::..|:
Human   503 --------------SGIHRSLGTRLSRVRSLELDDW-------PVELRKVMS--SIGNDLANSIW 544

  Fly  1132 RKSGSENSMHKLMSAFRADAFNVEITRNE--------YNEHDVANVLKRFMRDLPERLLGKLTDS 1188
              .||.....|.         :|:.||.|        |.|       |.|:..||          
Human   545 --EGSSQGQTKP---------SVKSTREEKERWIRSKYEE-------KLFLAPLP---------- 581

  Fly  1189 FVFVTEL--------AVASEKIPIYRELLARLSAIERETLRRIVG--------HLVFISSQQAKN 1237
               .|||        |.|.|.:.....|||..|   ||.:....|        ||..     .|.
Human   582 ---CTELSLGQHLLRATADEDLQTAILLLAHGS---REEVNETCGEGDGCTALHLAC-----RKG 635

  Fly  1238 KMSVQNLTMIWGPTLLAK 1255
            .:.:..|.:.:|..::|:
Human   636 NVVLAQLLIWYGVDVMAR 653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP15BNP_573183.2 RhoGAP_ARAP 1095..1277 CDD:239850 39/185 (21%)
AGAP5NP_001137472.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..242 10/42 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 256..278 6/32 (19%)
PH_AGAP 280..447 CDD:241281 38/237 (16%)
PH 283..442 CDD:278594 34/205 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..404 3/21 (14%)
ArfGap 466..580 CDD:279720 27/156 (17%)
ANK <590..677 CDD:238125 16/72 (22%)
Ank_2 591..681 CDD:289560 16/71 (23%)
ANK repeat 591..621 CDD:293786 9/32 (28%)
ANK repeat 623..654 CDD:293786 6/36 (17%)
ANK 1 623..652 5/33 (15%)
ANK 2 656..685
ANK repeat 656..681 CDD:293786
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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