DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and Arap1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_006508249.1	Gene:	Arap1 / 69710	MGIID:	1916960	Length:	1452	Species:	Mus musculus

Alignment Length:	1441	Identity:	304/1441 - (21%)
Similarity:	514/1441 - (35%)	Gaps:	399/1441 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 PDPDQ---EDDGCYEVPKTQGK----PPS-YDEALRSRPSP--SDSPMSRNLAQEAAQLVQLRN- 427
            |:|..   ||:|....|....:    ||: :.....:.|.|  ...|..|:|.:.:...|..|.
Mouse    99 PEPPPTAGEDEGLPAAPPIPPRRSCLPPACFTPTSTAAPDPVLPPLPAKRHLVEPSVPPVPPRTG 163

  Fly   428 ----QRQLSS------------SSSNGDESPRLPMPAFPPPRLSQQPEQFRMDALQPPVRQKRRK 476
                |..|.:            |.....|:|...:||||...| |.|.......:.||
Mouse   164 PPYPQASLLAKEELLLPSVSPRSQPEPAETPSTLLPAFPQGPL-QPPSPPPCPPVIPP------- 220

  Fly   477 NYEHIELRRPP-----VDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPER-----SDSW 531
                    :||     .|.:..:::......|...    :..|.....::.|:..|     |:..
Mouse   221 --------KPPRLLPEFDDSDYDDVPEEGPGAPAS----VMTKEEPLPSRVPRAVRVASLLSEGE 273

  Fly   532 EFYGEDENEEEDRDEEQEG----------------SSSPE-PLYANQEATYG--KLFEMATAGSS 577
            |..|:|  .|:|.|...||                |..|: ||:...|...|  .:..:..||..
Mouse   274 ELSGDD--SEDDDDHAYEGIPNGGWPTSGLNPPLRSLIPDLPLHPMDELPGGPTPITPVIKAGWL 336

  Fly   578 RSNVLTPNQVAEQQQLACITEDSE----LDACEGAVGGVPLPQAVIEEFDPLSSKCSTLARSNKS 638
            ..|   |.|.:...|...:..|::    .|:.:.|.....:|.|.|....|:..:...:..:|::
Mouse   337 DKN---PPQGSYIYQKRWVRLDADYLRYFDSNKDAYSKRFVPVACICRVAPIGDQKFEVITNNRT 398

  Fly   639 -----------NELL------LLEH-----LLEEDTYGTVKAEQDDVS---MCTSEEEPTTSAAT 678
                       ||.:      ::||     |......|...:||.|.:   .....:.....|.|
Mouse   399 FAFRAESDVERNEWMQALQQAVVEHRARFRLSSASVLGVRGSEQPDRAGSLELRGFKNKLYVAVT 463

  Fly   679 SPKPQQPQIVHQNA---------------------------------RLLSDSMENMLDSDQERA 710
            ..|.|    :::|.                                 |:.|.|.::.|:.:|
Mouse   464 GDKVQ----LYKNLEEFHLGIGITFIDMNVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQ--- 521

  Fly   711 KPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNTSKTTPPIEGDSPPTYLE--- 772
              :|..|..:..:|....::|...     |.......|:|.            |.:.|.:..
Mouse   522 --WLEAMQGAIAEALSTSEVAERI-----WAAAPNRFCADC------------GAAQPDWASINL 567

  Fly   773 AIGGSKDAAGNQENRSTIGSRFRQTINAISNVK-LKMDAMKRKA------------------SFR 818
            .:...|..||  |:|. :|:       .:|.|: ||||   ||.                  .|.
Mouse   568 CVVICKRCAG--EHRG-LGA-------GVSKVRSLKMD---RKVWTEALIQLFLHLGNGPGNHFW 619

  Fly   819 GANQRQSDVRVALQMVPRPSLSPLLIRY-------EGPLVRFPS--GVVEDILK---------EM 865
            .||...|:   ||:    ||.||...||       ||...|:..  |..|::.|         ::
Mouse   620 AANVPPSE---ALE----PSSSPGARRYHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDL 677

  Fly   866 QNRKAI---------------------LRERQFQT----FL--DQEMKTPREMIPLDTITTLQCV 903
            ...:|:                     |.|:..||    ||  :|..:.||    ||::..|:
Mouse   678 AETQALLGCGAGVSCFSGDPAAPTPLALAEQAGQTLQMEFLRNNQSTEVPR----LDSVKPLE-- 736

  Fly   904 SNSRVT-DTATH--FYCFEITTSQPKNGNGAGDAMSSNPNLLMTS-----------SSSGNVKQQ 954
            .:..|| .|.:|  |.....:..:|.....|.:..|....:|...           :.:|.::..
Mouse   737 KHYSVTLPTVSHSGFLYKTASAGKPLQDRRAREEFSRRWCVLSDGVLSYYENERAVTPNGEIRAS 801

  Fly   955 RV-------------SHLYGVGKESER----GV--------WMQKILESLTNSLPVKYTCH-YYR 993
            .:             .|.:.|..|.||    |:        |::.|.::....|....... :.|
Mouse   802 EIVCLAVSPLDTHGFEHTFEVYTEGERLYLFGLENAELAHEWVKCIAKAFVPPLAEDLLARDFER 866

  Fly   994 AGW--CYLKNSITSEWSGTWLVLRKSQRRLIFVSEANGNVEK-MDLRKARCIVLKESDESIDNLH 1055
            .|.  |....|:.....| |..|..|:.|.:|   ..|..|: :.|||.:.:.::...|:...:.
Mouse   867 LGRLPCKAGLSLQQAQEG-WFALTGSELRAVF---PEGPWEEPLQLRKLQELSIQGDSENQVLVL 927

  Fly  1056 VESGPMLMIDCPPYAVYMIMSSARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFV 1120
            ||....|.|.......:|         .|..:|::.|.:.|.:|.:|||...|:||||.:|::::
Mouse   928 VERRRTLYIQGERRLDFM---------AWLGVIQKAAASLGDTLSEQQLGDSDIPVIVYRCVDYI 983

  Fly  1121 YIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHDVANVLKRFMRDLPERLLGKL 1185
            ...|..|||||||.|..:...:|:.:.|.||.:|.:...|.:..||::.||||:||||:.|..:.
Mouse   984 TQCGLTSEGIYRKCGQTSKTQRLLDSLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRA 1048

  Fly  1186 TD-SFVFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWG 1249
            .. :::..:|:....|||..|||||..|..:.|.|::.::.||..:......|:|:..||.:::|
Mouse  1049 QRLAWLEASEIEDEEEKISRYRELLVHLPPVNRATVKALISHLYCVQCFSDTNQMNTHNLAIVFG 1113

  Fly  1250 PTLLAKKSDELIYSQKEADVLSDLVVLYKNLFPCSADEIKREQAMLACLQKYYAAAETLKDAVKQ 1314
            |||.  ::|...|  |...|:.||:..|..:|....:|:::::..:..:.|...|...  ...:.
Mouse  1114 PTLF--QTDGQDY--KAGKVVEDLINHYVVVFSVDEEELRKQREEVTAIVKMRVAGTA--SGTQH 1172

  Fly  1315 SGDIKIWISLNPNPENKTEEKTQVNATISPTKTAYELCREYSAKMQLPTHQ---LTLYEVILNDS 1376
            :||....:.|.   |.|.|  |:.:..|..:.||.||..|...:..:...:   .|.:||...:.
Mouse  1173 AGDFICTVYLE---EKKVE--TEQHVKIPASMTAEELTLEILDRRNVSIREKDYWTCFEVNEKEE 1232

  Fly  1377 LERPLHHDTKVFDVILNWSYWPEEDRKH-----NYLVVRPVEMLREIQRAVKNLATVTPGKELRF 1436
            .|||||...||..::            |     ::|||:..:.:..:...:.:....|....::|
Mouse  1233 AERPLHFAEKVLPIV------------HGLGIDSHLVVKKYQSMEAMLLYLASRVGDTKHGMMKF 1285

  Fly  1437 ADSRT-------------KTFKTLQCELRDGKIVVSKKDKNDKTTI----VREIFLQSSTAYLGC 1484
            .:.|:             :.|......||..|.|.|::..:.....    .:|..::|...|||.
Mouse  1286 REDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPVKSLKVYLGV 1350

  Fly  1485 ERKRDFPWSWAITFVERTQAQIMRSRDAPFIGHVLAGSEWGDRTIWYSSI--------WYCLY-- 1539
            ::|...|..|..|.|..|:..                    ::..||...        |:..:
Mouse  1351 KKKLRPPTCWGFTVVHETEKH--------------------EKQQWYLCCDTQMELREWFATFLS 1395

  Fly  1540 --RDNILPPAE 1548
              .|.::.|:|
Mouse  1396 VQHDGLVWPSE 1406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	65/182 (36%)
Arap1	XP_006508249.1	SAM_Arap1,2,3	6..68	CDD:188889
		PH1_ARAP	331..422	CDD:270073	16/93 (17%)
		PH2_ARAP	438..527	CDD:270074	14/97 (14%)
		ArfGap_ARAP	537..652	CDD:350066	34/151 (23%)
		PH3_ARAP	745..851	CDD:270076	16/105 (15%)
		PH-like	864..954	CDD:388408	23/102 (23%)
		RhoGAP_ARAP	959..1137	CDD:239850	65/181 (36%)
		RA_ARAP1	1173..1265	CDD:340746	27/108 (25%)
		PH5_ARAP	1265..1404	CDD:270079	24/158 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6683
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001278
OrthoInspector	1	1.000	-	-		otm44184
orthoMCL	1	0.900	-	-		OOG6_104434
Panther	1	1.100	-	-	LDO	PTHR45899
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3385
SonicParanoid	1	1.000	-	-		X1129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.800