Protein Alignment RhoGAP15B and Agap2

DIOPT Version :9

• Sequence 1: NP_573183.2
• Gene: RhoGAP15B / 32686
• FlyBaseID: FBgn0030808
• Length: 1552
• Species: Drosophila melanogaster
• Sequence 2: XP_038935796.1
• Gene: Agap2 / 65218
• RGDID: 628844
• Length: 1304
• Species: Rattus norvegicus
• Alignment Length: 1220
• Identity: 228/1220 - (18%)
• Similarity: 383/1220 - (31%)
• Gaps: 428/1220 - (35%)

  Fly    94 PVYATP----RPAPRQRL----PPAGEPEDSYPDPDDEVPLRILRAAPQIPPKPLNILLDQRSSI 150
            |..|:|    .|||.:||    .|.|.|......||.:.     ..||....:||
  Rat    95 PAPASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKP-----GGAPSSSRRPL---------- 144

  Fly   151 CSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSHSG----KFKSQSPGYVDAVDSSIPQSDH 211
                    :.:|.....:.||   .:...:..|.|.|.|    :.|...|
  Rat   145 --------LSSPSWGGPEPEG---RTGGGVPGSSSPHPGTGSRRLKVAPP--------------- 183

  Fly   212 PDPNGHHPQAESSSAEQSSGSQDGDDDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFK 276
                  .|..:......:||::.|.                |:..|.|:::.....|.|: :..|
  Rat   184 ------PPAPKPFKTVTTSGAKAGG----------------GKGAGSRLSWPESEGKPRV-KGSK 225

  Fly   277 SS--------------TEAIS---NIGADAGRSLKHASKRFGSNFSLGRNKDKADIGIGGRPG-- 322
            |:              :.|::   .:||.||...| .|.|.|.:.:|    |.:|:    .||
  Rat   226 STAGTGASAVAAGGGGSAAVTTSGGVGAGAGARGK-LSPRKGKSKTL----DNSDL----HPGPS 281

  Fly   323 -GSGEMDLDRRQTMPSTEVFNTIQFSSPL-----------------NRNGGLPDLRENDAKLQKE 369
             ||..:.:. ...:|:|.|  |...:.||                 .|.||....|  |.|:.|
  Rat   282 AGSPPLTVP-AIPVPATSV--TAASTQPLGPAPPITLEPPAPGLKRGREGGRASTR--DRKMLK- 340

  Fly   370 DYLRPDPDQEDDGCYEVPKTQGKPPSYDEALRSRPSPSDSPMSRNLAQEAAQLVQLRNQRQLSSS 434
             ::        .|.:  .|:.|.||.        |.|...|                   |..||
  Rat   341 -FI--------SGIF--TKSTGGPPG--------PGPLPGP-------------------QGLSS 367

  Fly   435 SSNGDESPRLPMPAFPPP-------RLSQQPEQFRMDALQPPVRQKRRK--------NYEHIELR 484
            ||...|.....:.|.|..       .||:...:.|:..| ..||..:..        :|:.:|
  Rat   368 SSGSRELLGAELRASPKAVVNSQEWTLSRSIPELRLGVL-GDVRSGKSSLIHRFLTGSYQVLE-- 429

  Fly   485 RPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPE-RSDSWE------FYGEDENEEE 542
            :|..:..:.|.|      .:.:..|::..:.|.|      |: :...|.      |..|||:.
  Rat   430 KPESEQYKKEML------VDGQTHLVLIREEAGA------PDAKFSGWADAVIFVFSLEDESS-- 480

  Fly   543 DRDEEQEGSSSPEPLYANQEATYGKLFEMATAGSSRSNVLTPNQVAEQQQLACITEDSELDACEG 607
                           :......:|:|..:  .|..|..:          .||.:.....:.|...
  Rat   481 ---------------FQAVSHLHGQLISL--RGEGRGGL----------ALALVGTQDRISASSP 518

  Fly   608 AVGGVPLPQAVIEEFDPLS--SKCSTLARSNKSNELLLLEHLLEE--DTYGTVKAEQDDVSMCTS 668
            .|.|....:|:..:....|  ..|:|..        |.::.:.:|  ....|::.:|..::.|.|
  Rat   519 RVVGDARARALCTDMKRCSYYETCATYG--------LNVDRVFQEVAQKVVTLRKQQQLLAACKS 575

  Fly   669 -EEEPTTSAATSP-----------------KPQQPQIVHQNARLL-------------------- 695
             ...|:.|||::|                 .|..|.:.|:..|..
  Rat   576 LPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRR 640

  Fly   696 ---------SDSMENMLDSDQE-----RAKP-----YLSRMPESANK--ASGPVDLASASRNRTN 739
                     |||.:..|||..|     ||.|     .|.|...|.||  ....|.|:|      |
  Rat   641 TSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSS------N 699

  Fly   740 WFVPDKASCSDVTPNTS-------KTTPPIEGDSPPTYLEAIGGSKDAAGNQENRSTI------- 790
            .|:....|.:|...:|.       :||..:.|..||..:.|.|.|....|..::.||:
  Rat   700 GFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGPE 764

  Fly   791 -GSRFRQTINAISNVKLKMDAMKR---KASFRGANQRQSDVRVALQMVP---RPSLSPLLIRYEG 848
             .:.......:.|:::|..|...:   |.....|....:|...:..:.|   .|..||::.:...
  Rat   765 ASTPMPSPSPSPSSLQLPTDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRR 829

  Fly   849 PLVRFPS---------------------GVVEDILKEMQNRKAIL-----RERQFQTFLDQEMKT 887
            ..:..||                     |.:.:|.|..:|.:.::     :...|:....:|...
  Rat   830 KKLSTPSKTEGSAVQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDA 894

  Fly   888 PREMIPLDTITTLQCVSNSRV---TDTATHFYCFEITTSQPKNGNGAGDAMSSNP-----NL--L 942
            ..:.|....:.:|||..:|:|   ||:.:.....: .....|..:...|..:.||     ||  |
  Rat   895 WVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQ-AIRNAKGNSTCVDCGAPNPTWASLNLGAL 958

  Fly   943 MTSSSSGNVKQQRVSH-------------------LYGVGKESERGVWMQKILESLT--NSLPVK 986
            :....|| :.:...:|                   |..:|.::...||     ||.|  .:.|.:
  Rat   959 ICIECSG-IHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVW-----ESDTRGRAKPTR 1017

  Fly   987 YTCHYYRAGWCYLKNSITSEWSGTWLVLRKSQRRLIFVS------EANGN-----VEKMDLRKAR 1040
            .:....|..|                 :|....:|:|::      |..|.     ||..|: .|.
  Rat  1018 DSSREERESW-----------------IRAKYEQLLFLAPLGTTEEPLGRQLWAAVEAQDV-AAV 1064

  Fly  1041 CIVLKES-----DESIDNLHVESGPMLMIDCPPYAVYMIMSSARETKIWR 1085
            .::|..:     |.|:::..:.|...|..:.....:..::...||.::||
  Rat  1065 LLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWVRERRVWR 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Agap2	XP_038935796.1	PRK07764	<37..174	CDD:236090	24/104 (23%)
		Centaurin_gamma	401..560	CDD:133303	33/210 (16%)
		PH_AGAP	668..908	CDD:241281	46/245 (19%)
		ArfGap_AGAP	926..1033	CDD:350065	21/130 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900