DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and appl1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_021335332.1	Gene:	appl1 / 571540	ZFINID:	ZDB-GENE-081016-1	Length:	708	Species:	Danio rerio

Alignment Length:	431	Identity:	86/431 - (19%)
Similarity:	146/431 - (33%)	Gaps:	135/431 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 GQNKLILQENNSDSQQPIYGPDANE------NVQEPVYATPRPAPRQRLPPAGEPEDSYPDPDDE 123
            |:...:||   :||::     |..|      |:.:.:|.:..|                    :|
Zfish   349 GKKAAVLQ---ADSRK-----DCEEWIATINNISKRIYLSENP--------------------EE 385

  Fly   124 VPLRILRAAPQ-IPPKPLNILLDQRSSICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSH 187
            :..|:.::|.: :.|.|         |......:....|.||....|.||:        ||..|.
Zfish   386 IAARVNQSALEAVTPSP---------SFQQRHESFRPNTQGKVKASRSGSQ--------CSVGSE 433

  Fly   188 SGKFKSQSPGYVDAVDSSIPQSDHPDP-NGHHPQAESSSAE--------QSSGSQDGDDDNNLL- 242
            |....|.|...:.|.|:.| |.|...| :..|.....|||:        :|.|||..:.::::|
Zfish   434 SPALSSLSLDSLVAPDTPI-QFDIISPVSEEHTSQTKSSAQGRRTNPFGESGGSQSEESEDSILH 497

  Fly   243 -----RSLGT-------TSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGADAGRSLKH 295
                 |.||:       :|.::.|.:.:.:..:|       ..|....||:...:..:..:.:..
Zfish   498 QLFIVRFLGSMEVKATESSDVIYETMRQILAARA-------IHNIFRMTESHLLVTCECLKLIDP 555

  Fly   296 ASKRFGSNFSL-------GRNKDKADIGI-----GGRPGGSG-------EMDLDRRQTMPSTEVF 341
            .::.....|.|       ...::|...|.     |||..|..       |.:.|..:...|..:.
Zfish   556 QTQVTRLRFPLSSVVLCASHQENKRLFGFVLQTAGGRADGQPVTVCYIFESNNDGEKICDSIGLA 620

  Fly   342 NTIQFSSPLNRNGGLPDLRENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKPPSYDE-----ALR 401
            ..|...|.::|.........:.||.::::.|......|.|              .:|     |..
Zfish   621 KQIALHSEMDRKASQKQRELDKAKEKQQEELHKQKQIEKD--------------LEEQSRLIAAS 671

  Fly   402 SRPSPSDSPMSRNLAQEAA--QLVQLRNQRQLSSSSSNGDE 440
            |||:           |.||  |.:.|.|.:  |..|..|:|
Zfish   672 SRPN-----------QPAADGQFLVLSNSQ--SEDSDVGEE 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
appl1	XP_021335332.1	BAR_APPL1	20..234	CDD:153315
		BAR-PH_APPL	252..376	CDD:270067	8/34 (24%)
		PTB_APPL	488..623	CDD:269980	21/141 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900