DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP15B and arap3

DIOPT Version :9

Sequence 1:NP_573183.2 Gene:RhoGAP15B / 32686 FlyBaseID:FBgn0030808 Length:1552 Species:Drosophila melanogaster
Sequence 2:XP_687312.3 Gene:arap3 / 558931 ZFINID:ZDB-GENE-091019-1 Length:1664 Species:Danio rerio


Alignment Length:1582 Identity:323/1582 - (20%)
Similarity:544/1582 - (34%) Gaps:494/1582 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 GTTSKLLGEAIGERITFKAKGAKKRLDRNF-KSSTEAISNIGADAGRSLKHASKRFGSNFSLGRN 309
            |||.:.|..:....:..:.|       |:| :.||..:..:  ...|::.|  |..|..|||...
Zfish   109 GTTFQALRNSSAPNLCAQVK-------RSFSERSTSVVKPV--PKPRTVFH--KLRGDKFSLATQ 162

  Fly   310 KDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLNRNGGL-PDLRENDAKLQKEDYLR 373
            .:.       |......:.:|......||:...|...|    :.|.| |.|.......:.|..|.
Zfish   163 HEH-------RKSSQDPVVIDSSSLSSSTDTVKTATES----KKGHLEPSLSCTALSPESEGPLP 216

  Fly   374 PDPDQEDDGCYEVPKTQGKPPSYDEALRSRP--SPSDSPMSRNLAQEAAQLVQLRNQRQLSSSSS 436
            |.|.:.:.|   :|.:..:..|..|.|.:.|  :|.|||.|...                     
Zfish   217 PVPPRLNRG---IPPSTFRRMSGQERLSTPPLCTPPDSPSSYQC--------------------- 257

  Fly   437 NGDESPRLPMPAFPPP----------------RLSQQPEQFRMDALQ-PPVRQKRRKNYE-HIEL 483
                ||....|..||.                .|...|..|...::. ||.||:...:.| |..|
Zfish   258 ----SPFTNTPGSPPSPPCSGLEMVSNEIYCGTLPDTPHVFWSRSVPVPPPRQEPSPSTENHSTL 318

  Fly   484 RRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPERSDSWEFYG--EDENEEEDRDE 546
            .:    |...|...|.:|:||.::.::    |...||           .|:.  :.::.|.:|.|
Zfish   319 EK----SNSSESSKRTSASAEEDDDMI----NPYCET-----------VFHSKRQYQHSEVERSE 364

  Fly   547 EQEGSSSPEPL---YANQEATYGKLFE---MATAGSSRSNVLTPNQVAEQQQLACITEDSELDAC 605
            .:|.:|:.|..   :.:...::.|..:   ..|.|.|..:...|:.:       |.:|..|    
Zfish   365 SKEKTSNKEDKLRDHGHHNHSWLKRLDSPGYCTVGESSHSFSLPHNL-------CSSEADE---- 418

  Fly   606 EGAVGGVPLPQAVIEEFDPLSSKCSTLARSNKSNELL--LLEHLLEEDTY----GTVKAEQDDVS 664
                             |.:|...|..:.|.::..:|  .|:.|..:..|    ..||.:..::.
Zfish   419 -----------------DIISPYASFTSLSERAAPILSGWLDKLSPQGNYVFQKRYVKFDGKNLM 466

  Fly   665 MCTSEEEPTTSAATSPKPQQPQIVHQNARLLSDSMENML----------DSDQERAKPYLSRMPE 719
            ...||::      ..||...|....|.|||..|:...::          |:|.:|:| :.|.:.|
Zfish   467 YFGSEKD------AYPKGVIPLAAIQMARLAKDNKFEIVTSHRTFVFRADNDVQRSK-WCSTLQE 524

  Fly   720 SANK--ASGPVDLASASRNRTNWFVPDKASCSDVTPNTS---------KTTPPIEGDSPPTYLEA 773
            ...:  ..|.......|..:.:.|:..|.:.|.:  .|:         |:....:.....|.:||
Zfish   525 RVKEQLVFGRPRFGPGSHCQKSGFLELKGTKSKI--YTAIIMEQIWLYKSEQCFKNGIGITVIEA 587

  Fly   774 IGGS-KDAAGNQENRSTIGSRFRQTINAISNVKLKMDAMKRKASFRGANQRQS-DVRVALQMVPR 836
            .|.: :|..|...:..|....|                     ||.....|:. |...|||    
Zfish   588 RGATIRDGKGKSFDLITPYKTF---------------------SFTAETDREKRDWMEALQ---- 627

  Fly   837 PSLSPLLIRYEGPLVRFPSGVVEDILKEMQNR-----KAIL------------------RERQFQ 878
            .|::..|..||         |.|.|.....|:     |||.                  :.|...
Zfish   628 ESIAETLSDYE---------VAEKIWSNRSNKICADCKAINPDWASINLCVVICKNCAGQHRGLG 683

  Fly   879 TFLDQEMKTPREMIPLDTITTLQCVSNSRV-------TDTATHFYCFEITTSQPKNGNGAGD--- 933
            |     |.:..:.:.|||    ...||..|       .|.|..|:...:..|:..:.:...:   
Zfish   684 T-----MVSKVQSLKLDT----SVWSNEIVQLFIMLGNDRANEFWAARLPVSEELDCDATPEQRR 739

  Fly   934 -----------------AMSS-------------NPNLLMT-------------SSSSGNVKQQR 955
                             :.||             ..|||.|             :.::||.|  |
Zfish   740 EFISHKYKEGRYRHPHPSFSSQEELLKALCTAVTEQNLLKTVTQIFAEAEAARLADANGNDK--R 802

  Fly   956 VSHLYGVGKESERGVWMQKILESLTNSLPVKYTCHYYRAG-------------------WCYLKN 1001
            ||..|...:.::..|: .:|::      |:.|:...|::|                   ||.::.
Zfish   803 VSPHYSYTQSADSCVY-DEIMQ------PILYSGFLYKSGSLNKGTLSRRTRDADFQKYWCSVEK 860

  Fly  1002 SI--------------------------------------------------------------- 1003
            ||                                                               
Zfish   861 SILFYESDRCHEPSMKIDVKDIICLGVSRPDSSNNSGFIDKFRYTFELYLMSDKLVQFGLETPDA 925

  Fly  1004 --------------------------------------TSEWSGTWLVLRKSQRRLIFVSEANGN 1030
                                                  ..:|...:.||:||.   :|:...|..
Zfish   926 LHSWARAIGKATTPLSCHCLLAREFERVGVLRYKAMLDPQQWKEGFFVLQKSN---LFICPGNDG 987

  Fly  1031 VEK--MDLRKARCIVL---KESDESIDNL-HVESGPMLMIDCPPYAVYMIMSSARETKIWRHIIR 1089
            ..:  ::|::.:.:.:   .|:.|..|.| .||.|..|         ::..:...:..:|...|:
Zfish   988 AAEDIINLKRLQELSIASEMENHEKKDILVLVEKGRTL---------HLQGTGRTDFSLWYADIQ 1043

  Fly  1090 EVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNV 1154
            :.|...|.:|.||||:|.|:|:|||.||.|:..:|...||||||:|:::.:..||..||.||.||
Zfish  1044 KAAGGKGNTLKDQQLSRNDIPIIVDSCIAFITQYGLGHEGIYRKNGAKSRIKLLMEEFRKDARNV 1108

  Fly  1155 EITRNEYNEHDVANVLKRFMRDLPERLLGKLTDSFVFVTELAVASEKIPI-------YRELLARL 1212
            ::...:....||.:|||||.|::.:.:.  :.|...|..|.|    |||:       |:||:..|
Zfish  1109 KLRIGDNFIEDVTDVLKRFFREIDDPIF--MADLHPFWKEAA----KIPLKTQRLDRYKELIRGL 1167

  Fly  1213 SAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQKEADVLSDLVVLY 1277
            ..:.|.||..::.||..:......|:|..:||::::.|:|......    .:.|..::.||:..|
Zfish  1168 PRVNRTTLAALISHLYRVQKCADLNQMCTKNLSLLFAPSLFQTDGK----GEHEVKIIEDLIDNY 1228

  Fly  1278 KNLFPCSADEIKREQAMLACLQKYYAAAETLKDA-VKQSGDIKIWISLNPNPENKTEEKTQ---V 1338
            ..:|  ..||..:.|..|.     .:...|.:|. :.|:||:.|.:.|        |||..   :
Zfish  1229 LYIF--DVDEEHQTQIDLE-----ISLITTWRDTQLSQAGDLIIEVYL--------EEKIPDCCI 1278

  Fly  1339 NATISPTKTAYELCREYSAKMQLPTHQLTL---YEVILNDSLERPLHHDTKVFDVILNWSYWPEE 1400
            ...:|||..|.||..:......:|..:..:   :|.|.:..||||||...||.:..|.|.  ...
Zfish  1279 TLKVSPTMCAEELTNQVLYMRNIPAGEKDVWMTFEAIEDGELERPLHPKEKVLEQALQWC--KMA 1341

  Fly  1401 DRKHNYLVVRPVEMLREIQRAVKNLATVTPGKELRFADSRTK-----TFKTLQCELRDGKIVVSK 1460
            |....||||:.|.....|.......:.:.....|:..:...|     .|:....:::|.|:::.|
Zfish  1342 DPSSAYLVVKKVPRGEAIDIFTAYKSEIVKSGVLKCREEPPKLLQGNKFQERSFQIKDHKLLLMK 1406

  Fly  1461 KDKNDKTTIVREIFLQSSTAYLGCERKRDFPWSWAIT-FVERTQAQIMRSRDAPFIGHVLAGSEW 1524
            ..|::|..  :|..|::...|:|..:|...|..|.:| .:::.|..:..|.:...         |
Zfish  1407 DKKSNKPE--KEWQLKTLKIYMGIRKKLKPPTKWGLTVLLDKQQLYLSCSCETEL---------W 1460

  Fly  1525 GDRTIWYSSIWYCLYRDNILPP 1546
            .    |.:::... ..|::.||
Zfish  1461 D----WMTNLLKA-QNDDLRPP 1477

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP15BNP_573183.2 RhoGAP_ARAP 1095..1277 CDD:239850 64/188 (34%)
arap3XP_687312.3 SAM_Arap1,2,3 8..70 CDD:188889
SAM 9..70 CDD:197735
PH 436..527 CDD:278594 22/97 (23%)
PH1_ARAP 437..529 CDD:270073 22/98 (22%)
PH2_ARAP 538..627 CDD:270074 19/111 (17%)
PH 545..631 CDD:278594 21/112 (19%)
ArfGap 638..754 CDD:279720 21/133 (16%)
PH3_ARAP 824..937 CDD:270076 8/112 (7%)
PH 825..936 CDD:278594 7/110 (6%)
PH-like 950..1045 CDD:302622 18/106 (17%)
PH 954..1045 CDD:278594 18/102 (18%)
RhoGAP_ARAP 1050..1228 CDD:239850 64/187 (34%)
RA 1261..1355 CDD:279168 32/103 (31%)
PH5_ARAP 1357..1477 CDD:270079 22/135 (16%)
PH 1369..1469 CDD:278594 20/114 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001278
OrthoInspector 1 1.000 - - otm25182
orthoMCL 1 0.900 - - OOG6_104434
Panther 1 1.100 - - O PTHR45899
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3385
SonicParanoid 1 1.000 - - X1129
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.940

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