DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and ASAP3

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_011540057.1	Gene:	ASAP3 / 55616	HGNCID:	14987	Length:	926	Species:	Homo sapiens

Alignment Length:	483	Identity:	95/483 - (19%)
Similarity:	163/483 - (33%)	Gaps:	157/483 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RPANYENIEIRRPNSPSNNINHNNIKKLNINAENLHGNCAEKKLPSSGQNKLILQ--ENNSDSQQ 80
            :|:...::..||....:..:.|...::.....:.|......:.|.|      :|:  .|..|..|
Human   519 KPSAESDMGTRRDYIMAKYVEHRFARRCTPEPQRLWTAICNRDLLS------VLEAFANGQDFGQ 577

  Fly    81 PIYGPDANENVQEPVYATPRPAPRQRLP-------PAGEPEDSYPDPDDEVPLRILRAAPQIPPK 138
            |:.||||....:..::...:.|.:..||       ..|..:....|.:..:..    ||....|.
Human   578 PLPGPDAQAPEELVLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHY----AALYNQPD 638

  Fly   139 PLNILLDQRSSICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSH------------SGKF 191
            .|.:||..|:.:            |..:|       |...:||.:...|            :|.|
Human   639 CLKLLLKGRALV------------GTVNE-------AGETALDIARKKHHKECEELLEQAQAGTF 684

  Fly   192 KSQSPGYVDA--VDSSIPQSDH---------PDPNGHHPQAESSSAEQSSGSQDGDDDNNLLRSL 245
              ..|.:||.  |.|:.|.||.         |.|   .|||.....|::              .|
Human   685 --AFPLHVDYSWVISTEPGSDSEEDEEEKVGPSP---VPQASGWQKERA--------------RL 730

  Fly   246 GTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGA--DAGRS--------LKHASKRF 300
            |....|       ::..:|..|..|||.:.| :.|.::::||  ..|.|        :|::|:..
Human   731 GLRCLL-------KLPAQAHWASGRLDISNK-TYETVASLGAATPQGESEDCPPPLPVKNSSRTL 787

  Fly   301 GSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLNRNGGLPDLRENDAK 365
            ....:...:.|::::         ..:..:..:|..|        ..||.:.:..:..|...
Human   788 VQGCARHASGDRSEV---------SSLSSEAPETPES--------LGSPASSSSLMSPLEPG--- 832

  Fly   366 LQKEDYLRPDPDQEDDGCYEVPKTQGKPPSYDEALR-----SRPS------PSDSPMSRNLAQEA 419
                     ||.|             .||:.:|.||     ||||      ||:..:....:.|:
Human   833 ---------DPSQ-------------APPNSEEGLREPPGTSRPSLTSGTTPSEMYLPVRFSSES 875

  Fly   420 AQLVQLRNQRQLSSSSSNGDESPRLPMP 447
            .     |:.|:.:.|..:| .|.|.|:|
Human   876 T-----RSYRRGARSPEDG-PSARQPLP 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
ASAP3	XP_011540057.1	BAR_ASAP3	35..243	CDD:153324
		PH_ASAP	296..402	CDD:270071
		PH	309..392	CDD:278594
		ArfGap	430..545	CDD:279720	4/25 (16%)
		ANK repeat	553..586	CDD:293786	12/38 (32%)
		ANK repeat	588..621	CDD:293786	4/32 (13%)
		ANK	<592..676	CDD:238125	18/106 (17%)
		Ank_5	610..664	CDD:290568	14/76 (18%)
		ANK repeat	623..654	CDD:293786	9/46 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810