DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and si:ch1073-416j23.1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_695377.7	Gene:	si:ch1073-416j23.1 / 553480	ZFINID:	ZDB-GENE-100922-35	Length:	671	Species:	Danio rerio

Alignment Length:	742	Identity:	143/742 - (19%)
Similarity:	242/742 - (32%)	Gaps:	250/742 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 FEMATAGSSRSNVLTPNQVAEQQQLACI-------TEDSELDACEGAVGGVPLPQAVIEEFDPLS 626
            ||....|||..:.:....|.|...| |:       ..:|||:..|           |:..|:...
Zfish    17 FEFVKEGSSDDSTMGDQFVREVLSL-CLQRLAIEEASNSELEFIE-----------VVRNFEAAR 69

  Fly   627 SK-CSTLARSNKSNELLL------------LEHL---LEEDTYGTVKAEQDDVSMCTSEEEPTTS 675
            .| ........|..|||:            |:|.   |:.:.....|||.|  ..|..
Zfish    70 KKWLHAELELKKQKELLVKSDVARAALEVKLKHARNQLDVEIKKRYKAEAD--YQCLE------- 125

  Fly   676 AATSPKPQQPQIVHQNARLLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASASRNRTNW 740
                   :|.|::..  .|:.||..|...:|::|:.                  |.|.|.
Zfish   126 -------RQMQLICD--VLVHDSKSNACLNDEQRSM------------------LTSFSH----- 158

  Fly   741 FVPDKASCSDVTPNTSKTTPPIEGDSPPTYLEAIGGSKDAAGNQENRSTIGSRFRQTINAISNVK 805
                |.:|  |..:..|....|:..|   :|.....|.|...:                   ::.
Zfish   159 ----KGAC--VPQHRGKRLSVIDESS---FLSHSDISYDRTDD-------------------DLD 195

  Fly   806 LKMDAMKRKASFRGANQRQSDVRVALQMVPRPSLSPLLIRYEGPLVRFP-------SGVVEDILK 863
            |...|..:....|...:|:|.:                    ||:|..|       ||...|:|.
Zfish   196 LDSTAFVKPLKSRARERRRSSL--------------------GPVVSLPVPKRGRISGRSGDLLV 240

  Fly   864 EMQNRKAILRERQFQTFLDQEMKTPREMIPLDTITTLQCVSNSRVTDTATHFYCFEITTSQPKNG 928
            ...              |::|::|          |.::...::..|.:..|. ..:||...|:
Zfish   241 SRP--------------LEKEIET----------TVVKASVSTPETGSQIHM-VIDITQEAPE-- 278

  Fly   929 NGAGDAMSSNPNLLMTSSSSGNVKQQRVSHLYGVGKESERGVWMQ------KILESLTNSLPVKY 987
                     :|:..:.:....:|.:|.....:....::|..|.|:      .:|:.||.::. |.
Zfish   279 ---------HPSRALRNEHFSSVAEQTSVWAHSEVIQAETMVEMEVSAVEPAVLQDLTPTVE-KT 333

  Fly   988 TCHYYRAGWCYLKNSITSEWSGTWLVLRKSQRRLIFVSEANGNVEKMDLRKARCIVLKESDESID 1052
            ..|.::.     |..|..|   |.|...|   |:.|        .|:.::...|.|:.
Zfish   334 VQHVFQQ-----KTVIRPE---TCLPCGK---RIRF--------GKLAVKCRDCRVVS------- 372

  Fly  1053 NLHVESGPMLMIDCPPYAVYMIMSSARETKIWRHIIREVAHNNGFSLGD-QQLTRYDVPVIVDKC 1116
              |.|...:....|.|.|                  ...:|.|..:|.. ...||..:|.|:.:|
Zfish   373 --HPECKRLCPERCSPNA------------------HGSSHPNEETLESFAPSTRPRIPSIIVQC 417

  Fly  1117 INFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEY-------------NEHDVAN 1168
            ::.:...|...:||||..|.|..:.:|              |.:|             ..|.|..
Zfish   418 VHEIERRGLEEKGIYRVPGGERQVKEL--------------REKYLYGKGPLMLHKVDEVHAVCG 468

  Fly  1169 VLKRFMRDLPERLLG-KLTDSFVFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVFISS 1232
            :||.|:|.|.|.|:. ||..:|:..:|:|...:.:....:.:..|....|:||..::.||..: .
Zfish   469 LLKDFLRKLSEPLITFKLHRTFMEASEMADEDKSVETLLKTIRELPQPNRDTLAFLMLHLQRV-M 532

  Fly  1233 QQAKNKMSVQNLTMIWGPTLLAKKSDE 1259
            |....:|.:.||:.::|||::.....|
Zfish   533 QSPLCQMDLNNLSRVFGPTIIGHAMSE 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	45/180 (25%)
si:ch1073-416j23.1	XP_695377.7	C1	336..384	CDD:237996	14/75 (19%)
si:ch1073-416j23.1	XP_695377.7	RhoGAP_MgcRacGAP	402..587	CDD:239847	43/173 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580459
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840