DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and ASAP1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_001349853.1	Gene:	ASAP1 / 50807	HGNCID:	2720	Length:	1132	Species:	Homo sapiens

Alignment Length:	413	Identity:	89/413 - (21%)
Similarity:	124/413 - (30%)	Gaps:	159/413 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 PVYATPRPAPRQRLPPAGEPEDSYPDPDDEVPLRILRAAPQIPPK---------PLNILLDQRSS 149
            |.::|||  .:|||.........:.....:.|......||.:||:         |..:.|..::|
Human   757 PGFSTPR--DKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTS 819

  Fly   150 ICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSHSGKFKSQSPGYVDAVDSSIPQSDHPDP 214
              |..||.|.:.|                             ....||:...:      ||.|.|
Human   820 --SGSSTLSKKRP-----------------------------PPPPPGHKRTL------SDPPSP 847

  Fly   215 NGHHPQAESSSAEQSSGSQDGDDDNNLLRSLGTTSKLLG-----------EAIGERITFK--AKG 266
            ..|.|        .:.|:....:|.....|..||:|..|           .|:|.|:..|  .|.
Human   848 LPHGP--------PNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKV 904

  Fly   267 AKKRLDRNFKSSTEAISNIGADAGRSLKHAS---KRFGSNFSLGRNKDKADIG------------ 316
            |.::.|.                 .||..|:   :.|..:..|.....|...|
Human   905 ALRKTDH-----------------LSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPK 952

  Fly   317 --IGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLNRNGGL---PDLRENDAKLQKEDYLRPDP 376
              ||..|...||:                    .|..:.|.|   |.|.:...|.|.:| |.|.|
Human   953 PQIGDLPPKPGEL--------------------PPKPQLGDLPPKPQLSDLPPKPQMKD-LPPKP 996

  Fly   377 --------DQEDDGCYEVPKTQGKPPSYDEALRSRP---SPSDSPMSRNLAQEAAQLVQLRNQRQ 430
                    .|..|   ..||.|  .|| :..|:|.|   ||:               ||.|:..|
Human   997 QLGDLLAKSQTGD---VSPKAQ--QPS-EVTLKSHPLDLSPN---------------VQSRDAIQ 1040

  Fly   431 LSSSSSNGDESPRLPMPAFPPPR 453
            ..:|..:.|.:|.||....|.||
Human  1041 KQASEDSNDLTPTLPETPVPLPR 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
ASAP1	NP_001349853.1	BAR_ASAP1	54..268	CDD:153325
		PH_ASAP	319..425	CDD:270071
		ArfGap	442..558	CDD:307528
		ANK 1	603..635
		ANK	<604..692	CDD:238125
		ANK repeat	604..637	CDD:293786
		ANK repeat	639..670	CDD:293786
		ANK 2	639..668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	716..763		2/5 (40%)
		Atrophin-1	<727..1063	CDD:331285	87/411 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..1065		82/389 (21%)
		SH3_ASAP1	1074..1130	CDD:212898
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900