DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and zgc:92360

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_001002715.1	Gene:	zgc:92360 / 436988	ZFINID:	ZDB-GENE-040718-470	Length:	377	Species:	Danio rerio

Alignment Length:	192	Identity:	41/192 - (21%)
Similarity:	70/192 - (36%)	Gaps:	69/192 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   867 NRKAILRERQ----FQTFLDQEMKTPREMIPLDTITTLQCVSNSRVTDTATHFYCFEITTSQP-K 926
            ||:.:|..|:    :.|.||  .|.|:.::.:||:..                 ||     || |
Zfish   150 NRRFVLSVREGILKYYTKLD--AKEPKALMKVDTLNA-----------------CF-----QPDK 190

  Fly   927 NGNGAGDAMSSNPNLLMTSSSSGNVKQQRVSHLYGVGKESERGV--WMQKILESLTNSLPV---- 985
            .|         |||.|..:....|:.:    ::: |..:|.:.:  |...|..:..:.|.|
Zfish   191 IG---------NPNGLQITYIKDNITR----NIF-VYHDSSKEIVDWFNSIRAAQLHYLKVAFPG 241

  Fly   986 --------KYTCHYYRAGWCYLKNSITSEWSG---TWLVLRKSQRRLIFVSE-----ANGNV 1031
                    |.|..:.:.|  |::.:...:..|   .|..|  ..|||::..:     |.|.|
Zfish   242 ATDAELKPKLTRSFLKEG--YMEKTGPRQTEGFKKRWFTL--DHRRLMYFKDPLDAFAKGEV 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
zgc:92360	NP_001002715.1	ArfGap	8..124	CDD:279720
		PH1_ADAP	132..240	CDD:270072	28/127 (22%)
		PH	134..230	CDD:278594	26/117 (22%)
		PH2_ADAP	254..359	CDD:241282	11/50 (22%)
		PH	257..358	CDD:278594	11/47 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900