DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and Arfgap2

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_006234592.1	Gene:	Arfgap2 / 362162	RGDID:	1306177	Length:	534	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	100/461 - (21%)
Similarity:	164/461 - (35%)	Gaps:	120/461 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 SRYASNASLDCSES--SHSGKFK--------SQSPGYVDAVDSSIPQSDHPDPNGHHPQA---ES 223
            :|:.::..:|...|  |||.:.|        :|:|.:..|.         .||:|....|   ||
  Rat   127 ARHGTDLWIDNMNSAPSHSPEKKDSDFFTEHTQAPAWDTAA---------TDPSGTQQPALPSES 182

  Fly   224 SSAEQSSGSQDGDDDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGAD 288
            ||..|.....:.|       .|||:.    :|..|.:...|||...  .|..|||.
  Rat   183 SSLAQPEPGPNTD-------LLGTSP----QASLESMYLSAKGLSS--TRELKSSI--------- 225

  Fly   289 AGRSLKHASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLNRN 353
            .|:....|:|:                |:|.:.|    :...:......||:....|.:..|.
  Rat   226 IGKKKPAAAKK----------------GLGAKKG----LGAQKVSNQSFTEIERQAQVAEKLR-- 268

  Fly   354 GGLPDLRENDAKLQKED-----------YLRPDPDQEDDGCYEVPKTQGKPPSYDE----ALRSR 403
                :.:..|||.|.|:           .|:.|..:|:.   ::...:||.....|    .|.||
  Rat   269 ----EQQAADAKKQAEESMVASMRLAYQELQIDRKKEEK---KLQNLEGKKREQAERLGMGLVSR 326

  Fly   404 PSPSDSPMSRNLAQEAAQLVQLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQP----EQF--R 462
            .|.|.|.:|.      .|:::........||.|..|....:...|..||:....|    |.|  |
  Rat   327 SSISHSVLSE------MQMIEQETPLSAKSSRSQLDLFDDVGTFASGPPKYKDNPFSLGETFGSR 385

  Fly   463 MDALQPPVRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPER 527
            .|:       ......:.:|.:.|.|..:.:..::....:....||.:...:::||..|....:.
  Rat   386 WDS-------DAAWGMDRVEEKEPEVTISSIRPISERTTSRREVESRISGLESSEARQKFAGAKA 443

  Fly   528 SDSWEFYG---EDENEEEDRDEEQEGSS--SPEPLYANQEATYGKLFEMATAGS-SRSNVLTPNQ 586
            ..|..|:|   :.|.|...|.::..|||  |...|:.:.:..:|       .|: |..|||....
  Rat   444 ISSDMFFGREVDSEYEARSRLQQLSGSSAISSSDLFGDVDGAHG-------GGTVSLGNVLPTAD 501

  Fly   587 VAEQQQ 592
            :|:.:|
  Rat   502 IAQFKQ 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Arfgap2	XP_006234592.1	PLN03114	12..484	CDD:178661	92/429 (21%)
Arfgap2	XP_006234592.1	ArfGap	14..117	CDD:214518
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900