DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP15B and Arap1

DIOPT Version :9

Sequence 1:NP_573183.2 Gene:RhoGAP15B / 32686 FlyBaseID:FBgn0030808 Length:1552 Species:Drosophila melanogaster
Sequence 2:XP_006229959.1 Gene:Arap1 / 361617 RGDID:1310385 Length:1454 Species:Rattus norvegicus


Alignment Length:1453 Identity:309/1453 - (21%)
Similarity:504/1453 - (34%) Gaps:422/1453 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   374 PDPDQ---EDDG-----------------CYEVPKTQGKPPSYDEALRSRPS------PSDSPMS 412
            |:|..   ||.|                 |:..|.|  .||  |..|...|:      ||..|:.
  Rat   100 PEPPPTAGEDQGLPAAPPIPPRRSCLPPACFTPPST--APP--DPVLPPLPAKRHSVEPSLPPVP 160

  Fly   413 RNLAQEAAQLVQLRNQRQLSSSSS-----NGDESPRLPMPAFPPPRLSQQPEQFRMDALQPPVRQ 472
            ........|...|..:..|..|.|     ...|:|...:||||     |.|.|.......|||..
  Rat   161 PRTGPPYPQTSLLSKEELLLPSVSPWSQPEPTETPSTLLPAFP-----QGPLQPPSPPPCPPVIP 220

  Fly   473 KRRKNYEHIELR-RPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPER-----SDSW 531
            .:       .|| .|..|.:..:::......|...    :..|.....::.|:..|     |:..
  Rat   221 PK-------PLRLLPEFDDSDYDDVPEEGPGAPAS----VMTKEEPLPSRVPRAVRVASLLSEGE 274

  Fly   532 EFYGEDENEEEDR-------------------------------DEEQEGSSSPEPLY------- 558
            |..|:|..:|:|.                               ||...||:...|:.       
  Rat   275 ELSGDDAEDEDDHAYEGIPNGGWPTIGLNPPLSSLIPDLPLHPMDELPGGSTPTTPVIKAGWLDK 339

  Fly   559 -------------------------ANQEATYGKLF-------EMATAGSSRSNVLTPNQVAEQQ 591
                                     :|::| |.|.|       .:|..|..:..|:|.::....:
  Rat   340 NPPQGSYIYQKRWVRLDADHLRYFDSNKDA-YSKRFVPVACICRVAAIGDQKFEVITNSRTFAFR 403

  Fly   592 QLACITEDSELDACEGAV------------------GGVPLP-QAVIEEFDPLSSKCSTLARSNK 637
            ..:.:..:..:.|.:.||                  ||...| .|...|.....:|.......:|
  Rat   404 AESDVERNEWMQALQQAVVEHRAHIRLSSASVLGVRGGTEQPDHAGSLELRGFKNKLYVAVAGDK 468

  Fly   638 SNELLLLE--HLLEEDTY-----GTVKAEQDDVSMCTSEEEPTTSAATSPKPQQPQIVHQNARLL 695
            ......||  ||....|:     |.||           |.:..:...|:|           .|:.
  Rat   469 VQLYKNLEEFHLGIGITFIDMNVGNVK-----------EVDRRSFDLTTP-----------YRIF 511

  Fly   696 SDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNTSKTTP 760
            |.|.::.|:.:|     :|..|..:..:|....::|...     |.......|:|.         
  Rat   512 SFSADSELEKEQ-----WLEAMQGAIAEALSTSEVAERI-----WAAAPNRFCADC--------- 557

  Fly   761 PIEGDSPPTYLE---AIGGSKDAAGNQENRSTIGSRFRQTINAISNVK-LKMDAMKRKA------ 815
               |.:.|.:..   .|...|..||  |:|. :|:       .:|.|: ||||   ||.      
  Rat   558 ---GAAQPDWASINLCIVICKRCAG--EHRG-LGA-------GVSKVRSLKMD---RKVWTETLI 606

  Fly   816 ------------SFRGANQRQSDVRVALQMVPRPSLSPLLIRY-------EGPLVRFPS--GVVE 859
                        .|..||...|:   ||:    ||.||...||       ||...|:..  |..|
  Rat   607 QLFLQLGNGPGNHFWAANVPPSE---ALE----PSSSPGARRYHLEAKYREGKYRRYHPLFGNQE 664

  Fly   860 DILK---------EMQNRKAI---------------------LRERQFQT----FL--DQEMKTP 888
            ::.|         ::...:|:                     |.|:..||    ||  :|..:.|
  Rat   665 ELDKALCAAVTTTDLAETQALLGCGAGVNCFSGDPAAPTPLALAEQAGQTLQMEFLRNNQSTEVP 729

  Fly   889 REMIPLDTI--------TTLQCVSNSRVTDTATHFYCFEITTSQPKNGNGAGDAMSSNPNLLMTS 945
            |    ||::        .||..||:|       .|.....:..:|.....|.:..|....:|...
  Rat   730 R----LDSVKPSEKHYSITLPTVSHS-------GFLYKTASAGKPLQDRRAREEFSRRWCVLSDG 783

  Fly   946 -----------SSSGNVKQQRV-------------SHLYGVGKESER----GV--------WMQK 974
                       :.:|.::...:             .|.:.|..|.||    |:        |::.
  Rat   784 VLSYYENERAVTPNGEIRASEIVCLAVSPLDTHGFEHTFEVYTEGERLYLFGLENAELAHEWVKC 848

  Fly   975 ILESLTNSLPVKYTCH-YYRAGW--CYLKNSITSEWSGTWLVLRKSQRRLIFVSEANGNVEK-MD 1035
            |.::....|....... :.|.|.  |....|:.....| |..|..|:.|.:|   ..|..|: :.
  Rat   849 IAKAFVPPLAEDLLARDFERLGRLPCKAGLSLQQAQEG-WFALTGSELRAVF---PEGPWEEPLQ 909

  Fly  1036 LRKARCIVLKESDESIDNLHVESGPMLMIDCPPYAVYMIMSSARETKIWRHIIREVAHNNGFSLG 1100
            ||:.:.:.::...|:...:.||....|.|.......:|         .|...|::.|.:.|.:|.
  Rat   910 LRRLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFM---------AWLGAIQKAAASLGDTLS 965

  Fly  1101 DQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHD 1165
            :|||...|:||||.:||:::...|..|||||||.|..:...:|:.:.|.||.:|.:...|.:..|
  Rat   966 EQQLGDSDIPVIVYRCIDYITQCGLTSEGIYRKCGQTSKTQRLLDSLRQDARSVHLKEGEQHVDD 1030

  Fly  1166 VANVLKRFMRDLPERLLGKLTD-SFVFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVF 1229
            |::.||||:||||:.|..:... :::..:|:....|||..|||||..|..:.|.|::.::.||..
  Rat  1031 VSSALKRFLRDLPDGLFTRAQRLAWLEASEIEDEEEKISRYRELLVHLPPVNRATVKALISHLYC 1095

  Fly  1230 ISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQKEADVLSDLVVLYKNLFPCSADEIKREQAM 1294
            :......|:|:..||.:::||||.  ::|...|  |...|:.||:..|..:|....:|:::::..
  Rat  1096 VQCFSDTNQMNTHNLAIVFGPTLF--QTDGQDY--KAGKVVEDLISHYVVVFSVDEEELRKQREE 1156

  Fly  1295 LACLQKYYAAAETLKDAVKQSGDIKIWISLNPNPENKTEEKTQVNATISPTKTAYELCREYSAKM 1359
            :..:.|...|...  ...:.:||....:.|.   |.|.|  |:.:..|..:.||.||..|...:.
  Rat  1157 VTAIVKMRVAGTA--SGTQHAGDFICTVYLE---EKKVE--TEQHVKIPASMTAEELTLEILDRR 1214

  Fly  1360 QLPTHQ---LTLYEVILNDSLERPLHHDTKVFDVI--------LNWSYWPEEDRKHNYLVVR--- 1410
            .:...:   .|.:||...:..|||||...||..::        |....:|..:....||..|   
  Rat  1215 NVSIREKDYWTCFEVNEKEEAERPLHFAEKVLPIVHGLGMDSHLVVKKYPSMEAMLLYLASRVGD 1279

  Fly  1411 ---PVEMLREIQRAVKNLATVTPGKELRFADSRTKTFKTLQCELRDGKIVVSKKDKNDKTTIVRE 1472
               .:...|| .|::..|...:.|...|:....:...: |..|:|..:......:.:.:..  :|
  Rat  1280 TKHGMMKFRE-DRSLLGLGLPSGGFHDRYFILNSSCLR-LYKEVRSQRPWSGAPETSHRPE--KE 1340

  Fly  1473 IFLQSSTAYLGCERKRDFPWSWAITFVERTQAQIMRSRDAPFIGHVLAGSEWGDRTIWYSSI--- 1534
            ..::|...|||.::|...|..|..|.|..|:..                    ::..||...   
  Rat  1341 WPVKSLKVYLGVKKKLRPPTCWGFTVVHETEKH--------------------EKQQWYLCCDTQ 1385

  Fly  1535 -----WYCLY----RDNILPPAE 1548
                 |:..:    .|.::.|:|
  Rat  1386 MELREWFATFLSVQHDGLVWPSE 1408

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP15BNP_573183.2 RhoGAP_ARAP 1095..1277 CDD:239850 66/182 (36%)
Arap1XP_006229959.1 SAM_Arap1,2,3 6..68 CDD:188889
SAM 10..65 CDD:197735
PH 331..421 CDD:278594 10/90 (11%)
PH1_ARAP 332..423 CDD:270073 12/91 (13%)
PH2_ARAP 440..529 CDD:270074 24/115 (21%)
ArfGap 539..655 CDD:279720 35/152 (23%)
PH3_ARAP 747..853 CDD:270076 17/112 (15%)
PH 748..852 CDD:278594 17/110 (15%)
PH-like 866..956 CDD:302622 22/102 (22%)
RhoGAP_ARAP 961..1139 CDD:239850 66/181 (36%)
RA 1176..1264 CDD:279168 24/92 (26%)
PH5_ARAP 1267..1406 CDD:270079 27/162 (17%)
PH 1303..1400 CDD:278594 18/119 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 104 1.000 Domainoid score I6548
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001278
OrthoInspector 1 1.000 - - otm46276
orthoMCL 1 0.900 - - OOG6_104434
Panther 1 1.100 - - LDO PTHR45899
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1129
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
88.000

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