DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and Git

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	155/745 - (20%)
Similarity:	235/745 - (31%)	Gaps:	252/745 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LRPANYENIEIRRPNSPSNNINHNNIKKLN-INAENLHGNCAEKKLPSSGQNKLILQENNSDSQQ 80
            ||..|:|         ||         .|| :|:.|.||      ..|..::.|:....||...:
  Fly    89 LRQGNWE---------PS---------VLNFVNSLNAHG------ANSVWEHHLLDGSTNSTGGK 129

  Fly    81 PIYGPDANENVQEPVYATPRPAPRQRLPPAGEPEDS-YPDPDDEVPLRILRAAPQIPPKPLNILL 144
            .:                    ||.|.|   .|:|: :|...|.:..:
  Fly   130 HV--------------------PRWRKP---TPKDALHPTKSDFIKAK----------------- 154

  Fly   145 DQRSSICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSHSGKFKSQSPGYVDAVDSSIPQS 209
                    .|:.|.|..|...|:| :|     |.|..|.|...|.:.      :.....|::..|
  Fly   155 --------HVNLTFVLKPSLQDDD-DG-----NGSAGCLEQELSRQL------HASVRTSNLETS 199

  Fly   210 -----DHPDPNGHHPQAESS----SAEQSSGSQDG-----DDDNNLLRSLGTTSKLLGEA----- 255
                 ...|||.:|....|:    :|:....||..     ..|.|.|...|.|...|..|
  Fly   200 LRFLVQGADPNYYHEDKLSTPLHMAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNT 264

  Fly   256 IGERITFKAKGAKKRLDRNFKSSTEAISNIGADAGRSLKHASKRF-------GSNFS----LGRN 309
            |.||:          ||..:..:...|:.:|   |:...|||.|.       |::.|    :.|.
  Fly   265 IAERL----------LDAMYDVTDRIITFLG---GKKPDHASGRHMIIPDANGADISEQLKIARG 316

  Fly   310 KDKADIGIGGRPGGSGE---MDL----DRRQ---------------TMPSTEV------------ 340
            |      :...|....|   |||    |||:               |:|....
  Fly   317 K------LQLVPNKMFEELVMDLYDEVDRRECEAIWSTSTLNADHATVPFLPANPFLSATRNQGR 375

  Fly   341 -----FNTIQFSSPLN-------RNGGLPDLRENDA------KLQKEDYLR------------PD 375
                 ||..:|:..|.       |...:.:||..||      .||...|..            .|
  Fly   376 QKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPMDAPVAGHQSLQSLPYANNSMLLGSFEQGGHD 440

  Fly   376 PDQEDDGCYEVPKTQGK-----PPSYDEALRSRPSPSDS------PMSRNLAQEAAQLVQLRNQR 429
            |:..||.....|.....     ||...:|:...|..|.:      .:.:.|....:::.||:|..
  Fly   441 PNLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRSANSHNEMETLRKQLNDYKSEINQLKNVV 505

  Fly   430 QLSSSSSNGDESPRLPMPAFPPPRLSQQPEQFRMD-ALQPPVRQKRRKNYEHIELRRP------- 486
            |:.||     |:.:|..........|...|..|:| :|..|       :.||..|..|
  Fly   506 QMLSS-----ENTQLKSKFSSASNNSVYDEPLRIDLSLSSP-------DTEHEPLSLPEGGTANG 558

  Fly   487 ----PVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPERSDSWEFYGEDENEEED---- 543
                ..||:....:.|.|:..||.....::..|.:....|...:.:...:.:||:.....|
  Fly   559 ESGSSNDSSNQSTIKRPASMYERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEEVKVRSDLVTR 623

  Fly   544 RDEEQEGSSSPEPLYANQE-ATYGKLFEMATAG--SSRSNVLTPN-QVAEQQQLACITEDSEL-- 602
            |.:|...:..|.|....|. |.:|:|...|...  :..:| |.|| ....::.|..:|..:.|
  Fly   624 RLKELIRAMQPVPEDQKQSIAPHGELIRSAVTDLIALYAN-LPPNASDPSRETLKLLTRQNILIQ 687

  Fly   603 DACEGAVGGVPLPQAVIEEFDPLSSKCSTL 632
            ..||..       |..||..|..:.:.:||
  Fly   688 HECENL-------QKAIEADDKQAIQKNTL 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Git	NP_610599.3	ArfGap	48..164	CDD:279720	27/146 (18%)
		Ank_2	187..279	CDD:289560	22/107 (21%)
		ANK	<187..270	CDD:238125	20/98 (20%)
		ANK repeat	187..213	CDD:293786	5/31 (16%)
		ANK repeat	215..247	CDD:293786	6/31 (19%)
		ANK repeat	249..279	CDD:293786	9/39 (23%)
		GIT_SHD	314..342	CDD:285690	10/33 (30%)
		GIT	374..404	CDD:128828	5/29 (17%)
		GIT1_C	609..727	CDD:289013	27/110 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900