DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and AGFG1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_001128659.1	Gene:	AGFG1 / 3267	HGNCID:	5175	Length:	584	Species:	Homo sapiens

Alignment Length:	565	Identity:	104/565 - (18%)
Similarity:	170/565 - (30%)	Gaps:	193/565 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 DEDREGSRYASN--ASLDCSESSHSGKFKSQSP-------------------------------- 196
            |.|:.|..|.:.  .|..|  :|.||..:..:|
Human    31 DCDQRGPTYVNMTVGSFVC--TSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIW 93

  Fly   197 -GYVDAVDSSIPQSDHPDPN--------------------------GHHPQAESSSAEQSSGSQD 234
             |..|...|:||  |..||.                          ..|.....|||..:|.:.:
Human    94 LGLFDDRSSAIP--DFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPE 156

  Fly   235 --------GDDDNNLLRSLGTTSK--LLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGAD- 288
                    ||....|..:.||.|:  ::|.:.|:      :..||:.|        .:|::|:|
Human   157 VKPLKSLLGDSAPTLHLNKGTPSQSPVVGRSQGQ------QQEKKQFD--------LLSDLGSDI 207

  Fly   289 --AGRSLKHASKRFGSNFS--------LGRNKDKADIGIGGRPGGS----GEMDLDRRQTMPSTE 339
              |......|:..| :||:        ...|.|.|:....|:..||    |..........|.|.
Human   208 FAAPAPQSTATANF-ANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQTT 271

  Fly   340 VFNTI-------QFSS--PL--NRNGGLPDLRENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKP 393
            .|..:       :|:|  ||  ..:|....:..|.|....    .|.....|.|.:...::.
Human   272 AFRMLSSSCSFGEFTSAFPLQATHSGSAASVNANFAHFDN----FPKSSSADFGTFNTSQSH--- 329

  Fly   394 PSYDEALRSRPSPSDSPMSRNLA--QEAAQLVQLRNQRQLSSSSSNGDE------SPRLPMPAF- 449
                     :.:.:.|.:|.|.|  |.|.:...|.|...:.|:...||:      :.:.|:.:.
Human   330 ---------QTASAVSKVSTNKAGLQTADKYAALANLDNIFSAGQGGDQGSGFGTTGKAPVGSVV 385

  Fly   450 -PPPRLSQQPEQFRMDALQPPVRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISA 513
             .|.:.|...:::                             |.|.||:...::|....:...|.
Human   386 SVPSQSSASSDKY-----------------------------AALAELDSVFSSAATSSNAYTST 421

  Fly   514 KNAEAETKTPKPERSDSWEFYGEDENEEEDRDEEQEGSSS-PEPLYANQEATYGKLFEMATAGSS 577
            .||.:......|..:.:               :.|..||| |.|..|......    .:|.||.|
Human   422 SNASSNVFGTVPVVASA---------------QTQPASSSVPAPFGATPSTNP----FVAAAGPS 467

  Fly   578 RSNVLTPNQVAEQQQLACITEDSELDACEGAVGGVPLPQAVIEEF 622
            .::...|.|...:...|.....:.:....|.  |.|.|.::...|
Human   468 VASSTNPFQTNARGATAATFGTASMSMPTGF--GTPAPYSLPTSF 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
AGFG1	NP_001128659.1	COG5347	8..319	CDD:227651	60/310 (19%)
AGFG1	NP_001128659.1	ArfGap	14..135	CDD:214518	18/107 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900