DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and agap3

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_009295860.1	Gene:	agap3 / 324332	ZFINID:	ZDB-GENE-110927-1	Length:	1295	Species:	Danio rerio

Alignment Length:	1448	Identity:	275/1448 - (18%)
Similarity:	448/1448 - (30%)	Gaps:	459/1448 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 SGKFKSQSPGYVDAVDSSIPQSDHPDPNGHHPQAESSSAEQSSGSQDGDDDNNL-----LRSLGT 247
            ||:.:.:......||.|::.:.|  |.|  ..||......|.|..|.......|     |.|.|.
Zfish    13 SGRAEKRGEDEFIAVKSNVGEED--DDN--ERQANQREERQESPGQRRSAAGKLNRWLYLSSTGN 73

  Fly   248 TSKLLGEAIGERITFKAKGAKKRLDR--------NFKSSTEAISNIGADAGRSLK----HAS-KR 299
            .....||.:|           .|.||        ..:||.|.....|.:....|:    |.. |.
Zfish    74 RGWRKGEVLG-----------MRTDRLPILRDNCTQQSSAEHFDFAGVEKALELRTGVCHIPFKE 127

  Fly   300 FGSNFSLGRNKDKADIGIGGRP-------GGSGEM------DLDRRQTMPST------------- 338
            ...|.....|..::.:.:..||       |....|      |.:|||...||
Zfish   128 LICNAVSVENATESHVVVLQRPAHGLRLLGSRRAMSMFVFPDNNRRQQTTSTNHQDSSTRPHSFC 192

  Fly   339 --EVFNTIQFSSP--LNRNGGLPDL----RENDAKLQKEDYLRPD-PDQEDDGCYEVPKTQGKPP 394
              |..|:.|...|  .:.|.|.||:    |...|:|:..|.|:|| |....    .:|....:||
Zfish   193 MLEATNSKQVILPTSASTNHGFPDVVQRCRTRRAELRAIDGLKPDMPPSAS----LLPLRLEEPP 253

  Fly   395 SYDEALRSRPSPSDSPMSRNLAQEAAQLVQLR--NQRQLSSSSSNGDESPRLPMPAFPPPRLSQQ 457
             ....|:||..|      |.::....:|.:.|  ::.:|:|.:..|.    ||.|.|......:|
Zfish   254 -IRRTLKSRSKP------RPVSMTVLELYKERSGSRDELASHTGTGS----LPRPGFRWKWFGRQ 307

  Fly   458 PEQFRMDALQPPVRQKRRKNYE-----------HIELR----RPPVDSAQLEELNRAAAAAEREE 507
            .....|...|...:.|.....|           .:.||    |...:.....||.|.|:..|:..
Zfish   308 ATGKEMGVTQISAKLKESNKEEAPKKMFGSLRRSLSLRMRRNRNQPEHEDRTELRRTASIGEKSM 372

  Fly   508 SLLISAKNAEAETKTPKPERSDSWEFYGEDENEEEDRDEEQEG-----------SSSPEPLYANQ 561
            ............|..|..|:.       ||:...:....:.:|           :...:|....|
Zfish   373 QSTRPFSYLTGRTLAPACEQD-------EDQGATQYIQYQTQGKVAVLEVPLRPAKLTKPTKQMQ 430

  Fly   562 EATYGKLFEMATAGSSRSNVLTPNQVAEQQQLACITEDSELDACEGAVGGVP-----LPQAVI-- 619
            ..|  ..:::..:...|...|:.|:             |||.....|||..|     .|.:|.
Zfish   431 PET--SFWQLIASRFKRKEPLSSNK-------------SELSTGSQAVGSHPPVRNKKPDSVAIE 480

  Fly   620 -----------EEFDPLSSKCSTLARS----------NKSNELLLLEHLLEEDTY--------GT 655
                       :.|  ::|:..||:||          |.|:....|.|.....||        |.
Zfish   481 TLAGIGFRKGQDSF--VNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGR 543

  Fly   656 VKAE------------------------------------QDDVSMCT-------------SEEE 671
            .|.|                                    :|::|..|             :.|.
Zfish   544 FKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLSSYRNAAEV 608

  Fly   672 PTTSAATSPKPQQPQIVHQNARLLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLAS---A 733
            |.....|     |..|...|.|::.|:....|.:|.:|:..|.:......|......|:|.   |
Zfish   609 PMVLVGT-----QDAISAANPRVIDDARARKLSNDLKRSTYYETCSTYGLNVERVFQDVAQKVVA 668

  Fly   734 SRNRTNWFVPDKASCSDVTPNTSKTTPPIEGDSPPTYLE--AIGGS--KDAAGNQENRSTIGSR- 793
            .|.:....:   ..|..:..:.|.::.| ....|..::.  |.||.  .|.:.:..:..:|..|
Zfish   669 LRKKQQLSI---GPCKSLPNSPSHSSVP-AASIPSVHINQAANGGGAFSDYSSSVPSTPSISQRE 729

  Fly   794 FRQTINAISNVKLKMDAMKRKASFRGAN----QRQSDVRVALQMVPR--------PSLSPLLIRY 846
            .|....|.||....:    ||.|.|.:|    ::.||...:::....        |....:|::.
Zfish   730 MRIETVAASNTPTPI----RKQSKRRSNIFTSRKASDQTKSIESKTDSIGSGRAIPIKQGILLKR 790

  Fly   847 EGPLVRFPSGVVEDILKEMQNRKAILRERQFQTF------------------LDQEMKTPREMIP 893
            .|          :.:.||.:.:...|.:....|:                  |...:|.|.:..|
Zfish   791 SG----------KSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPP 845

  Fly   894 LDTITTLQCVS---NSRVTDTAT-------------------------------------HFYCF 918
            ....|.....|   |....|.:|                                     |...|
Zfish   846 RAVATVAPTASPKTNGLTKDRSTLQLGIGATSTPHSNSSSSLQSGGSTAGVALGTNKEGMHQRSF 910

  Fly   919 EITTSQPKN--------GNGAGDAMSS--------NPNLLMTSSSSGNVKQQRVSHLYGVGKESE 967
            .:::::..|        .||..|.:||        :|.|....|...|.|:.|.....|:.|...
Zfish   911 SVSSAEQWNEAVISTTSANGVSDPLSSASGMSSATSPKLEPPPSPHANRKKHRRKKSTGITKPDS 975

  Fly   968 RGVWMQK-------ILESLTNSLPVKYTCHYYRAGWCYLKNSITSEWSGTWLVLRKSQRRLIFVS 1025
            .....::       |:.|||..:            |.:  .:.|.|....|:...:||   |..|
Zfish   976 LSAGSEEPEESFEFIIVSLTGQM------------WHF--EASTFEERELWVQAIESQ---ILAS 1023

  Fly  1026 EANGNVEKMDLRKARCIVLKESD----ESIDNLHVESGPMLMIDC----PPY------AVYMIMS 1076
                 ::..:..|.:..:..:||    :||.|:.   |.....||    |.:      |:..|..
Zfish  1024 -----LQSCESSKNKSRLGSQSDALAIQSIRNVR---GNSFCADCDAPNPDWASLNLGALICIEC 1080

  Fly  1077 SARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMH 1141
            |.....:..|:.|.           :.|...|.|  |:..:....|..:|:..::...
Zfish  1081 SGMHRNLGTHLSRV-----------RSLDLDDWP--VELSMVMTAIGNAMANSVWEAC------- 1125

  Fly  1142 KLMSAFRADAFN---VEITRNEYNEHDVANVLKRFMRDLPERLLGKLTDSFVFVTELAVASEKIP 1203
                   .|.:|   |:.||.|         .:|::|...|:.|        ||  :|:....:|
Zfish  1126 -------VDGYNKPGVDSTREE---------KERWIRAKYEQKL--------FV--VALPQSDVP 1164

  Fly  1204 IYRELLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQKEAD 1268
            :.::|   |.|:..:.||.:|..|...:.::.       |.|...|....|     |..|...|:
Zfish  1165 LGQQL---LRAVVEDDLRLVVLLLAHGTKEEV-------NETYGDGDGRTA-----LHLSCAMAN 1214

  Fly  1269 VLSDLVVLYKNLFPCSADEIKREQAMLACLQKYYAAAETLKDAVKQSG--------DIKIWISLN 1325
            |:...::::..:...|.|  .|.|..|:..|:  |.::...|.:.|.|        ........|
Zfish  1215 VVITQLLIWYGVDVKSRD--ARGQTPLSYAQR--AGSQECADILIQHGCPAEGGALSTPTATRHN 1275

  Fly  1326 PNPENKTEEKTQVNATIS 1343
            ||..|...:..::|.::|
Zfish  1276 PNINNNNGQCAELNRSLS 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	35/184 (19%)
agap3	XP_009295860.1	small_GTPase	507..672	CDD:197466	29/169 (17%)
		Centaurin_gamma	509..666	CDD:133303	27/161 (17%)
		PH_AGAP	778..1025	CDD:241281	44/278 (16%)
		PH	781..>845	CDD:278594	10/73 (14%)
		ArfGap	1044..1155	CDD:279720	28/157 (18%)
		Ank_2	1190..1259	CDD:289560	17/84 (20%)
		ANK	1199..>1259	CDD:238125	15/68 (22%)
		ANK repeat	1201..1232	CDD:293786	6/35 (17%)
		ANK repeat	1234..1259	CDD:293786	7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900