DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP15B and Agap1

DIOPT Version :9

Sequence 1:NP_573183.2 Gene:RhoGAP15B / 32686 FlyBaseID:FBgn0030808 Length:1552 Species:Drosophila melanogaster
Sequence 2:XP_038939665.1 Gene:Agap1 / 316611 RGDID:1309244 Length:1428 Species:Rattus norvegicus


Alignment Length:1665 Identity:328/1665 - (19%)
Similarity:503/1665 - (30%) Gaps:635/1665 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 PDANENVQEPVYATPRPAPRQRLPPAGEPEDSYPDPDDEVPLR--ILRAAPQIPPKPLNILLDQR 147
            |..:.:.|.|:.|  |||...|.||...|          .|.|  ||...|. .|:|.......|
  Rat    42 PPRSRDPQAPLGA--RPAVSARRPPPARP----------APARISILNRRPP-APRPTAAGATTR 93

  Fly   148 SS-------------ICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSHSGKFKSQSPGYV 199
            ::             :|.:....::: ||..|.:..|:  |:...| |:...|            
  Rat    94 AARNLGRGGGSRTAELCRKRPWDALR-PGALDNEAAGA--AARRGL-CAPRPH------------ 142

  Fly   200 DAVDSSIP-QSDHPDPNGHHPQAESSSAEQSSGSQDGDDDNNLLRSLGTTSKLLGEAIGERITFK 263
             .:...:| .|.||.|:|...:.. :.|....|::.|.......|||..     |.|        
  Rat   143 -LLARRVPCLSAHPAPHGSALRVR-TPAVGPRGTRTGGLQGRCSRSLSA-----GLA-------- 192

  Fly   264 AKGAKKRLDRNFK----SSTEAISNIGADAGRSLKHASKRFGSNFSLGRNKDKADIGIGGR---- 320
            |:|.:.|.....:    :|:...:.:.|..|.....||:                   ||.    
  Rat   193 ARGGRGRRSPPARALHLASSAPEARVPAAGGAGCSRASE-------------------GGEAAAA 238

  Fly   321 PG------GSGEMDLDRRQTMPSTEVFNTIQFSSPLNRNGGLPD----LRENDAKLQKEDYLRPD 375
            ||      ||||         |::...:|:        :.|:|.    .|.:...::||....|.
  Rat   239 PGDMYLLDGSGE---------PASSPADTM--------SRGMPPRKTVYRISVTMVRKEQLAAPA 286

  Fly   376 P-------------------DQEDDGCYEVPKTQGKPPSYD------------EALRSRP----- 404
            |                   ::.::...|.|:.  .|.::|            |..|.||     
  Rat   287 PRPTRRPRPARSPEAPGRLEEEAEEAAAEDPEI--GPRAWDFRAFRTRSTGQLELGRLRPCAHDT 349

  Fly   405 SPSD---SPMSRNLAQ---EAAQLVQLRNQRQLSSSSSNGDESPRLP----------------MP 447
            .|:|   ||.:...:.   |.|:...||  |.||....:..|.||.|                ||
  Rat   350 EPTDLMGSPTTEGPSSPDGEEARAAPLR--RSLSFRHWSEPEVPRSPALSGGRRHSSSGSLAWMP 412

  Fly   448 -------AFPPPRLSQQPEQFRMDALQPPVRQKRRKN--------YEHIELRRPPVDSAQLEELN 497
                   ..|.|....||...:.:.|.  |.:...||        :|..:.:...:|::.|:.|.
  Rat   413 DDDVEADVVPEPVAGVQPAAEKRNTLD--VGEVLSKNDALSDLERWERSKSKNRTLDNSDLQRLE 475

  Fly   498 RAAAA-----AEREESLL-----ISAKNAEAETKTPKPERSDSWEFYGEDENEEEDRD------E 546
            ||.||     |..|..||     |.|:....    |.| ||.:....|.........|      |
  Rat   476 RARAAAAGPGAASEHRLLRFFSGIFARRDGG----PSP-RSGALRSRGYFSLRRAPADTHSSSAE 535

  Fly   547 EQEGSSSPEPLYANQEATYG------KLFEMATAGSSRS----NVLTPNQVAE------------ 589
            ..|||...:....:||.|..      |:..:....|.:|    ..||...|.|            
  Rat   536 SIEGSPRRDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESPEDMDAGGRF 600

  Fly   590 --------QQQLACITEDSELDACEGAVGGVPLPQ------AVIEEF---DPLSSKC-----STL 632
                    |..|..|.::          ||.|..|      |||..|   |.:|.:.     |.:
  Rat   601 KKEIVVDGQSYLLLIRDE----------GGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYSRM 655

  Fly   633 ARSNKSNELLLL--------------------EHLLEED-----------TYG------------ 654
            |....::|:.|:                    ...|..|           |||            
  Rat   656 ANYRNTSEIPLVLVGTQDAISSTNPRVIDDVRARKLSNDLKRCTYYETCATYGLNVERVFQDVAQ 720

  Fly   655 ----TVKAEQDDVSMCTS-EEEPTTSAATSPKPQQPQIVH-----QNARLLSDSMENMLDSDQER 709
                |.|.:|..:..|.| ...|:.|:..|   .|...||     .....|||...::..:....
  Rat   721 KIVATRKKQQLSIGPCKSLPNSPSHSSVCS---AQVSAVHISQTSNGGGSLSDYSSSVPSTPSTS 782

  Fly   710 AKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNTSKTTPPIEGDSPPTYLEAI 774
            .|.....:|.:||.   |..:...|:.|:|.|...|.|..|                        
  Rat   783 QKELRIDVPPTANT---PTPVRKQSKRRSNLFTSRKGSDPD------------------------ 820

  Fly   775 GGSKDAAGNQENRSTIGSRFRQTINAISNVKLKMDAMKRKASFRGANQRQSDVRVALQMVPRPSL 839
               |:..|.:....:|||.        ..:.:| ..|..|.|.:..|:......|.|        
  Rat   821 ---KEKKGLESRADSIGSG--------RAIPIK-QGMLLKRSGKSLNKEWKKKYVTL-------- 865

  Fly   840 SPLLIRYEGPLVRFPSGVVEDILKEMQNRKAILRERQFQTFLDQEMKTPREMIPLDTITTLQCVS 904
                 ...|.|...||  :.|.::.:..::..|        |...:|.|.:..|           
  Rat   866 -----CDNGVLTYHPS--LHDYMQNVHGKEIDL--------LRTTVKVPGKRPP----------- 904

  Fly   905 NSRVTDTATHFYCFEITTSQPKNGNGAGDAMSSNPNLLMTSSSSGNVKQQRVSHLYGVGKESERG 969
              |.|..     |..|  |.||. ||....|||    |..|.:||||..       ..|.:...|
  Rat   905 --RATSA-----CAPI--SSPKT-NGLAKDMSS----LHISPNSGNVTS-------ASGSQMASG 948

  Fly   970 VWMQKILESLTNSLPVKYTCHYYRAGWCYLKNSITS--EWSGTWLVLRKSQRRLIFVSEA-NGNV 1031
            :.:...     ||.|         .|......|::|  :||...::...:      :|.| :|:.
  Rat   949 ISLVSF-----NSRP---------DGMHQRSYSVSSADQWSDATVIANSA------ISSAFSGSA 993

  Fly  1032 EKMDLRKARCIVLKESDESIDNLHVESGPMLMIDCPP-----------------YAVYMIMSSA- 1078
            ....|..:.|     |..||.:   .:.|.|  |.||                 :....:..:| 
  Rat   994 ADTGLGDSVC-----SSPSISS---STSPKL--DPPPSPHANRKKHRRKKSTSNFKADGLTGTAE 1048

  Fly  1079 ----------RETKIWR-HIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYR 1132
                      |:...|| ..:....|.   |||.::..|..:              ||......|
  Rat  1049 GSHSHSGLRLRDPVAWRPGDLHPQFHT---SLGQKRAPRPHL--------------GSFWVSAKR 1096

  Fly  1133 KSGSENSMHKLMSAFRADAFNVE-------------------ITRNEYNEHDVANVLKRFMRDLP 1178
            |:...|.:..|.:.:.:.:.|.|                   .....|.|.|.      :::.:.
  Rat  1097 KAWKLNRVGSLRNIYSSSSTNTEEQEENLEFIIVSLTGQTWHFEATTYEERDA------WVQAIE 1155

  Fly  1179 ERLLGKL--TDSFVFVTELAVASEKI---------------------PIYREL-LARLSAIERET 1219
            .::|..|  .:|....:.|...||.:                     |.:..| |..|..||...
  Rat  1156 SQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCDTQNPNWASLNLGALMCIECSG 1220

  Fly  1220 LRRIVG-HLVFISS--------QQAKNKMSVQN--LTMIW--------GPTLLAKKSDE-----L 1260
            :.|.:| ||..:.|        :..|...|:.|  ...:|        .|:|.:.:.::     .
  Rat  1221 IHRNLGTHLSRVRSLDLDDWPMELIKVMSSIGNELANSVWEEGSQGRTKPSLDSTREEKERWIRA 1285

  Fly  1261 IYSQKEADVLSDLVVLYKNLFPCSADEIKREQAMLACLQKYYAAAETLKDAVKQSGDIKIWISLN 1325
            .|.||          |:....||:  |....|.:|      :|.||.         |::..|.|.
  Rat  1286 KYEQK----------LFLAPLPCT--EFSLGQQLL------HATAEE---------DLRTVILLL 1323

  Fly  1326 PNPENKTEEKTQVNATI--SPTKTAYEL-CREYSAKM-QLPTHQLTLYEVILNDSLERPLHHDT- 1385
            .:     ..:.:||.|.  ...:||..| ||:.:..: ||    |..|.|   |.:.|..|.:| 
  Rat  1324 AH-----GSRDEVNETCGEGDGRTALHLACRKGNVVLVQL----LIWYGV---DVMARDAHGNTA 1376

  Fly  1386 ----------KVFDVILNWSYWPEE----------DRKHN 1405
                      :..||:|.:. .|:|          .||:|
  Rat  1377 LAYARQASSQECIDVLLQYG-CPDERFVLMATPNLSRKNN 1415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP15BNP_573183.2 RhoGAP_ARAP 1095..1277 CDD:239850 41/248 (17%)
Agap1XP_038939665.1 Centaurin_gamma 561..722 CDD:133303 29/170 (17%)
PH_AGAP 837..>911 CDD:241281 19/115 (17%)
PH-like <1123..1163 CDD:418428 4/45 (9%)
ArfGap_AGAP2 1180..1288 CDD:350078 17/107 (16%)
ANK repeat 1304..1332 CDD:293786 8/47 (17%)
Ank_2 1307..1397 CDD:403870 27/117 (23%)
ANK repeat 1339..1370 CDD:293786 11/37 (30%)
ANK repeat 1372..1397 CDD:293786 5/25 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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