Protein Alignment RhoGAP15B and Arap2

DIOPT Version :9

• Sequence 1: NP_573183.2
• Gene: RhoGAP15B / 32686
• FlyBaseID: FBgn0030808
• Length: 1552
• Species: Drosophila melanogaster
• Sequence 2: XP_038947855.1
• Gene: Arap2 / 305367
• RGDID: 1306452
• Length: 1709
• Species: Rattus norvegicus
• Alignment Length: 1796
• Identity: 367/1796 - (20%)
• Similarity: 609/1796 - (33%)
• Gaps: 568/1796 - (31%)

  Fly    36 NINHNNIKKLNINAENLHGNCAEKKLPSSGQNKLI--LQENNSDSQQ-PIYGPDANENVQEPVYA 97
            :||.|.:.::.|:             |:..:.:::  ||...|..|. |||   ||      ||.
  Rat    40 SINDNVLHQIGIS-------------PTGHRRRILKQLQMIFSKMQDFPIY---AN------VYK 82

  Fly    98 TPRPAPRQRLPPAGEPEDSYPDPDDEVPLRILRAAPQIPPKPLNILLDQRSSICSEVS-TTSVQT 161
            |..         ...|::.:..|...                        |:.|.|.| :.:|..
  Rat    83 TKN---------GSTPKEQHSAPSSS------------------------SNTCIEFSDSVTVHR 114

  Fly   162 PGKADEDREGSRYASNASLDCSESSHSGKFKSQSPGYVDAVDSSIPQSDHPDPNGHHPQAESSSA 226
            ||.|..:...:...|..  :|..|:...|.             |:..||.|.|.....|...||.
  Rat   115 PGPAPSEMVTTNVLSEG--NCHSSTSHDKL-------------SLSSSDLPCPEEEICQNVDSSQ 164

  Fly   227 EQSSGSQDGDDDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGADAGR 291
            :...|..:...|:.:.:.  ......||...|::...::.:.|.|:.|    ||.:.::  |...
  Rat   165 DYLFGRVNVKIDSLITQQ--AVEHTAGEEQTEKVNLVSEDSSKALNTN----TECLPSV--DHPA 221

  Fly   292 SLKHASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLNRNGGL 356
            |..|...  |:|..|                          ::.|.:..|   ||...:..|
  Rat   222 SETHCGN--GTNGVL--------------------------ESFPPSPFF---QFQGEMVVN--- 252

  Fly   357 PDLRENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGK---PPSYDEALRSRPSPSDSPMSRNLAQE 418
                        |.|:...|      .:...:::.|   .||....||.||.|.....:::::..
  Rat   253 ------------ELYVPSSP------IHSPMRSRSKLVSRPSRSFLLRHRPVPEIPGSTKSISGS 299

  Fly   419 AAQLVQLRNQRQLSSSS--------SNGDESPRLPMPAFPPPRLSQQPEQFRMDALQPPVRQKRR 475
                 ..|:::.:::|:        :|.|.|..:    ||      ..|.|....|:   ..|:|
  Rat   300 -----YFRDRKSITTSAGKSLTLKDANEDNSTSI----FP------YGETFLFQRLE---SSKKR 346

  Fly   476 --KN--YEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPERSDSWEFYGE 536
              ||  :.|             |:..:..||..|...|..|:.....:.|..:.:..|.|....:
  Rat   347 SIKNEFWAH-------------EDTVKEEAATSRNSILTKSSIYDSRKEKVSEDKVEDIWIPRED 398

  Fly   537 DENEEEDRDEEQEGSSSPE-------------------------------PLYANQEATYGKLFE 570
            ..|..:|...|.|.|:..|                               ||.:..|.|......
  Rat   399 KNNLPQDSASESEYSTVEECFQSLRRKNSKASKSRTQKAFYLDPFNRHSYPLSSTSENTDPSTIA 463

  Fly   571 MATA------GSSRSNV-------LTPNQVAEQQQ---------LACITEDSELDACEGAVGGVP 613
            .|.:      |||.:.|       |:|......|:         ::....|.|:    .:.|.:|
  Rat   464 NAISPYACFYGSSAAKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNDREM----YSKGIIP 524

  Fly   614 LPQAVI------EEFDPLSSKCSTLARSNKSNE-----LLLLEHL----LEEDTYGTVKAEQ--- 660
            |.....      .:|:.::::.:.:.|..|..|     .:||..|    |.......|..|:
  Rat   525 LTAISTVRAQGDNKFEIVTTQRTFVFRVEKEEERNDWISVLLSALKSPSLTSQLQAAVAPEKCGY 589

  Fly   661 ----------------DDVSMCTSEEEPTTSAATSPKPQQPQIVHQNARLLSDSMENM------- 702
                            :.|.:|.:|::..:....:..|.....|.|..|.:..|.|.:
  Rat   590 LELRGYKAKIFTVLRGNSVWLCKTEQDFKSGLGITIIPMNVANVKQIDRAVKQSFEIITPYRSFS 654

  Fly   703 --LDSDQERAKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSD--------------- 750
              .||::|: :.::..:.:|..:.....::|...     ||.....||:|
  Rat   655 FTADSEKEK-QEWIEAVQQSIAETLSDYEVAEKI-----WFNESNRSCADCKAPDPDWASINLCV 713

  Fly   751 ------------VTPNTSKTTPPIEGDSPPTYLEAIG-----GSKDA----AGNQENRSTI---- 790
                        :.|..||.. .::.|:.....|.|.     |:|.|    |||.:....|
  Rat   714 VICKKCAGQHRSLGPKDSKVR-SLKMDASIWSNELIELFIVIGNKRANDFWAGNLKKDEEIQMDS 777

  Fly   791 --------------GSRFRQTI----------NAISNVKLKMDAMKRKA-SFRGANQRQSDVRVA 830
                          ..:||:|.          .|:....:|.|.::..| .|.||     ||..|
  Rat   778 PVDKRKIFITQKYKEGKFRKTFLASLTKEELNKALCAAVVKPDVLETMALLFSGA-----DVMCA 837

  Fly   831 -------------------LQMVPRPSLSPLLIRYEGPLVRFP---------------------- 854
                               |||.         ..|......||
  Rat   838 TGDPVHCTPYLLAKKAGQSLQME---------FLYHNKFSDFPQYDAHSEGGSSQEATQSTFLCD 893

  Fly   855 ---------SGV-VEDILKEMQNRKAILRERQFQTFLDQE-MKTPREMIPLDTITTLQCVSNSRV 908
                     |.| .|..|.|..|:|..:.|..|.::.:.: ..||...|.:..:..|........
  Rat   894 FLYQATASASRVSTEKKLLEETNKKWCVLEGGFLSYYENDRCTTPNGTINISEVICLTVHKEDFY 958

  Fly   909 TDTATHFYCFEITTSQPKNGNGAGDAMSSNPNLLMTSSSSGNVKQQRVSHLYGVGKESERGVWMQ 973
            .:|.. .:.|||                             .:..:|| .|:|......:..|.:
  Rat   959 LNTGP-IFIFEI-----------------------------YLPSERV-FLFGAKTSQIQRKWTE 992

  Fly   974 KI--------LESLTNSLPVKYTCHYYRAGWCYLKN-SITSEWSGTWLVLRKSQRRLIF-VSEAN 1028
            .|        .|:||.:       .|...|..:.|: ....:|...|..:.||.  |.| :....
  Rat   993 TIAKRFVPFVAENLTEA-------DYDLIGQLFYKDCHALDQWRKGWFAMDKSS--LCFCLQTQE 1048

  Fly  1029 GNVEKMDLRKARCIVLK---ESDESID-NLHVESGPMLMIDCPPYAVYMIMSSARETKIWRHIIR 1089
            ...|:|.||:.:.:.:.   ::.|.:| .|.||.|..|         |:...:..:..:||:.|.
  Rat  1049 AQEERMHLRRLQELTISTVVQNGEKVDVLLLVEKGRTL---------YIHGYTKLDFTVWRNAIE 1104

  Fly  1090 EVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNV 1154
            :.|..:|.:|.||||.:.|||:||:.||.||..:|...:.||:|.|...|:.:|:.:|:.||.:|
  Rat  1105 KAAGTDGNTLQDQQLCKNDVPIIVNSCIAFVTQYGLGCKYIYQKDGDPLSISELLESFKKDARSV 1169

  Fly  1155 EITRNEYNEHDVANVLKRFMRDLPERLLGK-LTDSFVFVTELAVASEKIPIYRELLARLSAIERE 1218
            ::...::...||..|||.|:.|:.:.||.| |...:|...:.....::...||..:..|..:.|.
  Rat  1170 KLRVGKHQLEDVTGVLKSFLSDIDDALLTKELYPYWVSALDAQDEKQRTDKYRAFICSLPGVNRA 1234

  Fly  1219 TLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQKEADVLSDLVVLYKNLFPC 1283
            ||..::.||..:......|.|:..||.:::...|...|..    :.:|.:|:.||:..|..:|..
  Rat  1235 TLAALIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQ----TSEEVNVIEDLINNYVEIFEV 1295

  Fly  1284 SADEIKR-------------EQAMLACLQKYYAAAETLKDAVKQSGDIKIWISLNPNPENKTEEK 1335
            ..|::|:             .||.:.||.|   :.|.||  |.|:||:.|.:.     ..:.|..
  Rat  1296 KEDQVKQMDIENSFITKWKNTQASVHCLMK---SLERLK--VSQAGDLLIEVF-----AERKEPD 1350

  Fly  1336 TQVNATISPTKTAYELCREYSA-KMQLPTHQ--LTLYEVILNDSLERPLHHDTKVFDVILNWSYW 1397
            ..:...:||...|.||..:..| |..|||..  ...:|||.|:.||||||:...|.:.:|.||..
  Rat  1351 CSIIIRVSPVMEAEELTNDILAIKNILPTKGDIWATFEVIENEELERPLHYTENVLEQVLQWSSL 1415

  Fly  1398 PEEDRKH----NYLVVRPVEMLRE--IQRAVKNLATVTPGKEL---RFADSRTKTFKTLQC-ELR 1452
            .|....:    .:|.:..::..||  |:..:..|.. .|.|.|   :|.|         :| .||
  Rat  1416 AEPGSAYLVVKRFLTIDTIKQCREKSIKEGILKLKE-EPSKILSGNKFQD---------RCVVLR 1470

  Fly  1453 DGKIVVSKKDKNDKTTIVREIF-LQSSTAYLGCERKRDFPWSWAIT----------FVERTQAQI 1506
            ||.:.:.|..|:.|.   .::| |:....|||.::|...|.||.:|          ..:..|||:
  Rat  1471 DGHLFIYKDPKSTKH---EKMFPLRLMKFYLGVKKKMKPPTSWGLTACSEKHHWHLCCDSLQAQM 1532

  Fly  1507 MRSRDAPFIGHVLAGSEWGDRTIWYSSIWYCLYRDNILPPA 1547
            .                      |.:||:...:.::|.|||
  Rat  1533 E----------------------WMASIFIAQHENDIWPPA 1551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	56/182 (31%)
Arap2	XP_038947855.1	SAM_Arap1,2,3	6..68	CDD:188889	7/40 (18%)
		PH1_ARAP	480..571	CDD:270073	16/94 (17%)
		PH2_ARAP	581..671	CDD:270074	14/90 (16%)
		ArfGap_ARAP2	676..796	CDD:350081	19/125 (15%)
		PH-like	888..998	CDD:418428	23/140 (16%)
		PH-like	1011..1106	CDD:418428	24/105 (23%)
		RhoGAP_ARAP	1110..1289	CDD:239850	56/182 (31%)
		RA_ARAP2	1335..1432	CDD:340747	30/101 (30%)
		PH-like	1438..1549	CDD:418428	34/145 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6548
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001278
OrthoInspector	1	1.000	-	-		otm46276
orthoMCL	1	0.900	-	-		OOG6_104434
Panther	1	1.100	-	-	O	PTHR45899
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.910