Protein Alignment RhoGAP15B and RACGAP1

DIOPT Version :10

• Sequence 1: NP_573183.2
• Gene: RhoGAP15B / 32686
• FlyBaseID: FBgn0030808
• Length: 1552
• Species: Drosophila melanogaster
• Sequence 2: XP_024304726.1
• Gene: RACGAP1 / 29127
• HGNCID: 9804
• Length: 651
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 114/581 - (19%)
• Similarity: 217/581 - (37%)
• Gaps: 144/581 - (24%)

  Fly   862 LKEMQNRKAI-LRERQFQTF----LDQEMKTPREMIPLDTITTLQCVSNSRVTDTATHFYCFEIT 921
            ||..:|:..: ::.||....    |:::::..|||:..||..::|.   |....:|..|    :.
Human    91 LKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQL---SEEQKSALAF----LN 148

  Fly   922 TSQPKNGNGAGDAMSS----------------------NPNLLMTSSSSGNVKQQRVSHLY---- 960
            ..||.:.|.....:|:                      :.:|:.|.......|::..|..:
Human   149 RGQPSSSNAGNKRLSTIDESGSILSDISFDKTDESLDWDSSLVKTFKLKKREKRRSTSRQFVDGP 213

  Fly   961 --------GVGKESERGVWMQKILESLTNSLP--------------VKYTCHYYRAGWCYLKNSI 1003
                    .:|...::|  .:.|:...|.::|              |.|.....|      |...
Human   214 PGPVKKTRSIGSAVDQG--NESIVAKTTVTVPNDGGPIEAVSTIETVPYWTRSRR------KTGT 270

  Fly  1004 TSEW-SGTWLVLRKSQRRL----IFVSEANGN------VEKMDLRKARCIV----LKESDESID- 1052
            ...| |.:.|..|:.:.|.    :...::||.      |.|..::...|:.    :|....|:.
Human   271 LQPWNSDSTLNSRQLEPRTETDSVGTPQSNGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLSLKC 335

  Fly  1053 -NLHVESGPMLMIDCPPYAVYMIMSSARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKC 1116
             :..|.|.|.....||...:..::.:  ..||...::.:....          |...:|.||..|
Human   336 RDCRVVSHPECRDRCPLPCIPTLIGT--PVKIGEGMLADFVSQ----------TSPMIPSIVVHC 388

  Fly  1117 INFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHDVANVLKRFMRDLPERL 1181
            :|.:...|....|:||.||.:.::.:|...| .....|.:.....:.|.:.::||.|:|:|.|.|
Human   389 VNEIEQRGLTETGLYRISGCDRTVKELKEKF-LRVKTVPLLSKVDDIHAICSLLKDFLRNLKEPL 452

  Fly  1182 LG-KLTDSFVFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLT 1245
            |. :|..:|:...|:......|....:.:..|....|:||..::.||..: :|....||.|.||.
Human   453 LTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHLQRV-AQSPHTKMDVANLA 516

  Fly  1246 MIWGPTLLAKKSDELIYSQKEADVLSDLVVLYKNLFPCSADEIKRE----QAMLACLQKYYAAAE 1306
            .::|||::|       ::....|.::.|            .:|||:    :.:|:...:|::...
Human   517 KVFGPTIVA-------HAVPNPDPVTML------------QDIKRQPKVVERLLSLPLEYWSQFM 562

  Fly  1307 TLKD---------------AVKQSGDIKIWISLNP--NPEN---KTEEKTQVNATISPTKT 1347
            .::.               :..|:.|||:.: |.|  .||:   ||...:.::..:..|.|
Human   563 MVEQENIDPLHVIENSNAFSTPQTPDIKVSL-LGPVTTPEHQLLKTPSSSSLSQRVRSTLT 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	46/182 (25%)
		RA_ARAPs	1315..1416	CDD:340633	11/38 (29%)
RACGAP1	XP_024304726.1	SMC_prok_B	32..>124	CDD:274008	6/32 (19%)
		C1_MgcRacGAP	304..357	CDD:410371	10/52 (19%)
		RhoGAP_MgcRacGAP	365..558	CDD:239847	51/223 (23%)