DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and Appl1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_038951064.1	Gene:	Appl1 / 290537	RGDID:	1309388	Length:	720	Species:	Rattus norvegicus

Alignment Length:	782	Identity:	152/782 - (19%)
Similarity:	235/782 - (30%)	Gaps:	267/782 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 DDDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIG----------ADA- 289
            |..|.|..:...|||||.|.  |:..|...|..:.:....:..::.|..:.          |||
  Rat    49 DAQNELSAATHLTSKLLKEY--EKQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAM 111

  Fly   290 --------GRSLKH-----------------ASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDL 329
                    .|.||.                 |..|: |..|..|..||....:      :.::..
  Rat   112 MFPISQFKERDLKEILTLKEVFQIASNDHDAAINRY-SRLSKKRENDKVKYEV------TEDVYT 169

  Fly   330 DRR---QTMPSTEVF---NTIQFS------SPL----------------NRNGGLPDL------- 359
            .|:   |||  ...|   ||:|:.      .||                |.||.|.:.
  Rat   170 SRKKQHQTM--MHYFCALNTLQYKKKIALLEPLLGYMQAQISFFKMGSENLNGQLEEFLANIGTS 232

  Fly   360 -----RENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKPPSYDEALRSRPSPSDSPMSRNLAQEA 419
                 ||.|..::.......|.:...|..| :|.               |.|:..|::|||.::|
  Rat   233 VQNVRREMDGDVETMQQTIEDLEVASDPLY-LPD---------------PDPTKFPVNRNLTRKA 281

  Fly   420 AQLVQLRNQRQLSSSS----------------SNGDESPRLPMPAFPPPRLSQQPEQFR------ 462
            ..| ..||:..|.||:                :.||.:..|.|.......::...|..|
  Rat   282 GYL-NARNKTGLVSSTWDRQFYFTQGGNLMSQARGDVAGGLAMDIDNCSVMAVDCEDRRYCFQIT 345

  Fly   463 -MDALQPPVRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPE 526
             .|..:..:.|...|. :|.|.      ...:..:::....:|..|........:..|..||.|
  Rat   346 SFDGKKSSILQAESKK-DHEEW------ICTINNISKQIYLSENPEETAARVNQSALEAVTPSP- 402

  Fly   527 RSDSWEFYGEDENEEEDRDEEQEGSSSPEPLYANQEATYGKLFEMATAGSSRSNVLTPNQVAEQQ 591
                        :.::..:..:.|..|..|                ||.:|.|..|.    :|..
  Rat   403 ------------SFQQRHESLRPGGQSRPP----------------TARTSSSGSLG----SEST 435

  Fly   592 QLACITEDSELDACEGAVGGVPLPQAVIEEFDPLSSKCSTLARSNKSNELLLLEHLLEEDTYGTV 656
            .||.::.||           :..|...| :||.:|..|                    ||..|..
  Rat   436 NLAALSLDS-----------LVAPDTPI-QFDIISPVC--------------------EDQPGQA 468

  Fly   657 KA----------EQDDVSMCTSEEEPTTSAATSPKPQQPQIVHQ--NARLLSDSMENMLDSDQER 709
            ||          ..:......||.|..|.....|:.....|:||  ..|.|. |||  :.||..
  Rat   469 KAFGQGGRRTNPFGESGGSTKSETEGRTDCNVHPRVISNSILHQLFIVRFLG-SME--VKSDDH- 529

  Fly   710 AKPYLSRMPESANKASGPVDLASASRN---RTNWFVPDKASCSD-VTPNTSKT--TPPIEGDSPP 768
                    |:...:....:..|.|..|   .|...:.....|.. :.|.|..|  |.|:    |.
  Rat   530 --------PDVVYETMRQILAARAIHNIFRMTESHLLVTCDCLKLIDPQTQVTRLTFPL----PY 582

  Fly   769 TYLEAIGGSKDAAGNQENR-------STIGSRFRQTINAISNVKLKMDAMKRKASFRGANQRQ-- 824
            ..|.|.        :|||:       .|.|.|....::::..:            |...|:.:
  Rat   583 VVLYAT--------HQENKRLFGFVLRTSGGRSESNLSSVCYI------------FESNNEGEKI 627

  Fly   825 -SDVRVALQMVPRPSLSPLLIRYEGPLVRFPSGVVEDILKEMQNRKAILRERQFQTFLDQEMKTP 888
             ..|.:|.|:.....|.......:..:.|    |.|...||:..:|.|.::.:.|:.|......|
  Rat   628 CDSVGLAKQIALHAELDRRASEKQKEIER----VKEKQQKELSKQKEIEKDLEEQSRLIAASSRP 688

  Fly   889 RE 890
            .:
  Rat   689 SQ 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Appl1	XP_038951064.1	BAR_APPL1	20..234	CDD:153315	40/195 (21%)
		BAR-PH_APPL	252..376	CDD:270067	28/147 (19%)
		PTB_APPL	506..637	CDD:269980	34/166 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910