DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and Racgap1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_001240737.1	Gene:	Racgap1 / 26934	MGIID:	1349423	Length:	628	Species:	Mus musculus

Alignment Length:	617	Identity:	124/617 - (20%)
Similarity:	235/617 - (38%)	Gaps:	174/617 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   843 LIRYEGPLVRFPSG--VVEDILKEMQNRKAI-LRERQFQ----TFLDQEMKTPREMIPLDTITTL 900
            |.:::..|::..:|  .::..||..:|:..: ::.||..    ..|:|:::..|:::..||..::
Mouse    52 LEKFKDLLLKAETGRSALDVKLKHARNQVDVEIKRRQRAEAECAKLEQQIQLIRDILMCDTSGSI 116

  Fly   901 QCVSNSRVTDTATHFYCFEITTSQPKNGNGAGDAMSSNPNLLMTSSSSGNVKQQRVSHLYGVGKE 965
            |.   |....:|..|    :...|..:|: ||:      |.|.|...||::...     ....|.
Mouse   117 QL---SEEQKSALAF----LNRGQASSGH-AGN------NRLSTIDESGSILSD-----ISFDKT 162

  Fly   966 SERGVW---------MQKILESLTNSL--------PVKYTCHYYRAGWCYLKNSI--TSEWSGTW 1011
            .|...|         |:|..:..:||.        |||.||            ||  |.:.:...
Mouse   163 DESLDWDSSLVKNFKMKKREKRRSNSRQFIDGPPGPVKKTC------------SIGSTVDQANES 215

  Fly  1012 LVLRKSQRRLIFVSEANGNVEKMDL-----------RKARCIVLKESDESI-----------DNL 1054
            :|.:.:    :.|....|.:|.:..           .|:..:....||.::           |||
Mouse   216 IVAKTT----VTVPSDGGPIEAVSTIETLPSWTRSRGKSGPLQPVNSDSALNSRPLEPRTDTDNL 276

  Fly  1055 HV--ESGPMLMID-----------CPPYAVYM----IMSSARETKIWRHIIREVAH--------- 1093
            ..  .:|.|.:.|           |.|....:    :....|:.::       |:|
Mouse   277 GTPQNTGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLSLKCRDCRL-------VSHPECRDRCPL 334

  Fly  1094 -------NNGFSLGDQQLTRY------DVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMS 1145
                   .....:|:..|..:      .:|.||..|:|.:...|....|:||.||.:.::.:|..
Mouse   335 PCIPPLVGTPVKIGEGMLADFVSQASPMIPAIVVSCVNEIEQRGLTEAGLYRISGCDRTVKELKE 399

  Fly  1146 AFRADAFNVEITRNEYNEHDVANVLKRFMRDLPERLLG-KLTDSFVFVTELAVASEKIPIYRELL 1209
            .| .....|.:.....:.|.:.::||.|:|:|.|.||. .|:.:|:...|:...........:.:
Mouse   400 KF-LKVKTVPLLSKVDDIHVICSLLKDFLRNLKEPLLTFWLSKAFMEAAEITDEDNSTAAMYQAV 463

  Fly  1210 ARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQKEADVLSDLV 1274
            :.|....|:||..::.||..: ||....||.:.||..::|||::|.....           .|.|
Mouse   464 SELPQANRDTLAFLMIHLQRV-SQSPDTKMDIANLAKVFGPTIVAHTVPN-----------PDPV 516

  Fly  1275 VLYKNLFPCSADEIKRE----QAMLACLQKYY-----AAAETLKDAVKQSG-------DIKIWIS 1323
            .:::        :|||:    :.:|:...:|:     ...|.: |:.:.:|       |:|:.:
Mouse   517 TMFQ--------DIKRQLKVVERLLSLPLEYWNQFMMVDQENI-DSQRGNGNSTPRTPDVKVSL- 571

  Fly  1324 LNP--NPENKTEEKTQVNATISPTKTAYELCR 1353
            |.|  .||.:. .||.:::::|  :..|.|.:
Mouse   572 LGPVTTPEFQL-VKTPLSSSLS--QRLYNLSK 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	46/188 (24%)
Racgap1	NP_001240737.1	Tropomyosin	43..>108	CDD:395200	11/55 (20%)
		Interaction with SLC26A8. /evidence=ECO:0000250	107..286		41/213 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..284		6/41 (15%)
		C1_MgcRacGAP	286..339	CDD:410371	6/59 (10%)
		RhoGAP_MgcRacGAP	347..540	CDD:239847	50/213 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836936
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930