DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and Arfgap1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_001361599.1	Gene:	Arfgap1 / 228998	MGIID:	2183559	Length:	424	Species:	Mus musculus

Alignment Length:	327	Identity:	67/327 - (20%)
Similarity:	115/327 - (35%)	Gaps:	79/327 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   660 QDDVSMCTSEEEPTTSAATSPKPQQPQIVHQNARLLSDSMENMLDSD--QERAKPYLSRMPESAN 722
            |||.       ||:.|.......:...:.......|::..|..|:|.  |....|....:..:|:
Mouse    90 QDDY-------EPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAH 147

  Fly   723 KASGPVDLASASRNRT--NWFVPDKASCSDVTPNT----SKTTPP--IEGDSPPTYLEAI----- 774
            :|||....|:||.::.  :|...|..|......|.    ..|.||  .|.|.....:.::
Mouse   148 RASGQPQSAAASGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNNAMSSLYSGWS 212

  Fly   775 ----GGSKDAAGNQENRSTIGSRFRQTINAISNVKLKMDAMKRK---ASFRGANQRQSDVRVALQ 832
                |.||.|:..:|..:..||:..|          |....|::   ||..|.:..::.::.|.:
Mouse   213 SFTTGASKFASAAKEGATKFGSQASQ----------KFWGYKQQSEPASELGHSLNENVLKPAQE 267

  Fly   833 MVPR--------PSLSPLLIRYEG-------PLVRFPSGVVEDIL------KEMQN------RKA 870
            .|..        ..:|.|..:.:|       .:..|.||..||..      ...||      :.:
Mouse   268 KVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDSSDRPLEGHSYQNSSGDNSQNS 332

  Fly   871 ILRERQFQTFLDQEMKTPREMIP-LDTITTLQCVSNSRVTDTATHFYCFEI----TTSQPKNGNG 930
            .:.:..::||...|  .|:...| .|:.|.....:..|.:|:      :::    :.|..||.|.
Mouse   333 NIDQSFWETFGSAE--PPKAKSPSSDSWTCADASTGRRSSDS------WDVWGSGSASNNKNSNS 389

  Fly   931 AG 932
            .|
Mouse   390 DG 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Arfgap1	NP_001361599.1	ArfGap_ArfGap1	6..121	CDD:350059	7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900