DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and Adap2

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_742145.1	Gene:	Adap2 / 216991	MGIID:	2663075	Length:	381	Species:	Mus musculus

Alignment Length:	348	Identity:	67/348 - (19%)
Similarity:	114/348 - (32%)	Gaps:	91/348 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   706 DQERAKPYLSRMPESANKASGP-VDLASASRNRTNWFVPDKAS----------CSDV---TPNTS 756
            |:||.|..|..:.::|...:|. .|..:|.        ||.||          ||.|   .|:.|
Mouse     3 DRERNKKRLLELLQAAGTGNGHCADCGAAD--------PDWASYKLGIFICLHCSGVHRNFPDIS 59

  Fly   757 KTTP---PIEGDSPPTYLEAIGGSKDAAGNQENRSTIGSRFRQTINAISNVKLKMDAMKRKASFR 818
            |...   ....||...::           .......:.::|...:.|...|....|.:..|..:.
Mouse    60 KVKSVRLDFWDDSMVEFM-----------THHGNLNVKAKFEARVPAFYYVPQANDCLVLKEQWI 113

  Fly   819 GANQRQSDVRVALQMVPRPSLSPLLIRYEGPLVRFPSGVVEDILKEMQNRKAIL-RERQFQTFLD 882
            .|...:.:.....:.|..|.      ..||.|  :..|  .|..:.::.|..:| ||...:.:..
Mouse   114 RAKYERQEFTAIDKAVSHPG------NREGFL--WKRG--RDNAQFLRRRFVLLSREGLLKYYTK 168

  Fly   883 QEMKTPREMIPLDTITTLQCVSNSRVTDTATHFYCFEITTSQPKNGNGAGDAMSSNPNLLMTSSS 947
            :|.|.|:.:|.:..:..                     |....|.|:..|        |.:|...
Mouse   169 EEGKAPKAVISIKDLNA---------------------TFQTEKIGHPHG--------LQITYRK 204

  Fly   948 SGNVKQQRVSHLYGVGKE---------SERGVWMQKILESLTNS--LPVKYTCHYYRAGWCYLKN 1001
            .|:.:...|.|  ..|||         :.|..:::.....|..|  :|: .|.:|.:.|:.....
Mouse   205 EGHTRNLFVYH--DSGKEIVDWFNALRAARLQYLKLAFPDLPESELVPL-ITRNYLKQGFMEKTG 266

  Fly  1002 SITSE-WSGTWLVLRKSQRRLIF 1023
            ....| :...|..|...:|||::
Mouse   267 PKHREPFKKRWFALDPQERRLLY 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Adap2	NP_742145.1	ArfGap	9..123	CDD:279720	23/132 (17%)
		PH1_ADAP	133..241	CDD:270072	26/148 (18%)
		PH	135..231	CDD:278594	25/130 (19%)
		PH2_ADAP	255..362	CDD:241282	8/35 (23%)
		PH	258..361	CDD:278594	7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900