DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and Agap2

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_006513621.1	Gene:	Agap2 / 216439	MGIID:	3580016	Length:	1342	Species:	Mus musculus

Alignment Length:	1244	Identity:	238/1244 - (19%)
Similarity:	389/1244 - (31%)	Gaps:	393/1244 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PELRPANYENIEIRRPNSPSNNINHNNIKKLNINA----ENLHGNCAEKKLPSSGQNKLILQENN 75
            |.|.||         |.||:..::....::|::.|    ..|.|..:....|....
Mouse    91 PALSPA---------PASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKPGGAP--------- 137

  Fly    76 SDSQQPIYGPDANENVQEPVYATPRPAPRQRLPPAGEPEDSYPDPDDEVPLRILRAAPQIP-PKP 139
            |.|::|:        :..|.:..|.|..|   ...|.|..|.|.|.  ...|.|:.||..| |||
Mouse   138 SSSRRPL--------LSSPSWGGPEPEGR---TGGGVPGSSSPHPG--TGSRRLKVAPPPPAPKP 189

  Fly   140 LNILLDQRSSICSEVSTTSVQT-PGKADEDR------------EGSRYASNASLDCSESSHSGKF 191
            .           ..|:|:..:. .||....|            :||:..:......:.:...|..
Mouse   190 F-----------KTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSTAGTGASAAAAGGGGSA 243

  Fly   192 KSQSPGYVDA-------------VDSSIPQSD-HPDPNGHHP---------QAESSSAEQSSGSQ 233
            ...:.|.|.|             ...::..|| ||.|:...|         .|.|.:|
Mouse   244 AVTTSGGVGAGAGTRGKLSPRKGKSKTLDNSDLHPGPSAGSPPLTVPAIPVPATSVTA------- 301

  Fly   234 DGDDDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGADAGRSLKHASK 298
                         |:::.||.|....:...|.|.|:                |.:.||    ||.
Mouse   302 -------------TSTQPLGPAPPITLEPPAPGLKR----------------GREGGR----AST 333

  Fly   299 RFGSNFSLGRNKDKADIGI-----GGRPG--------------GSGEMDLDRRQTMPSTEVFN-- 342
            |       .|...|...||     ||.||              ||.|:.....:|.|...|.:
Mouse   334 R-------DRKMLKFISGIFTKSTGGPPGPGPLPGPQGLSSSSGSRELLGAELRTSPKAVVNSQE 391

  Fly   343 -TIQFSSPLNRNGGLPDLRENDA---------------KLQKEDYLRPDPDQEDDGCYEVPKTQG 391
             |:..|.|..|.|.|.|:|...:               |::.|.|.:   :...||
Mouse   392 WTLSRSIPELRLGVLGDVRSGKSSLIHRFLTGSYQVLEKIESEQYKK---EMLVDG--------- 444

  Fly   392 KPPSYDEALRSRPSPSDSPMSR---------NLAQEAAQLVQLRNQRQLSSSSSNGDESPRLPMP 447
              .::...:|......|:..|.         :|..|::.....|...||||....|.....|.:.
Mouse   445 --QTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDESSFQAVSRLHGQLSSLRGEGRGGLALALV 507

  Fly   448 AFPPPRLSQQPEQFRMDALQPPV-----------RQKRRKNYEHIELRRPPVDSAQLEELNRAAA 501
            .          .|.|:.|..|.|           ..||...||........||.. .:|:.:...
Mouse   508 G----------TQDRISASSPRVVGDARARALCTDMKRCSYYETCATYGLNVDRV-FQEVAQKVV 561

  Fly   502 AAEREESLLISAKNAEAETKTPKPERS-DSWEFYGEDENEEEDRDEEQEGSSSPEPLYANQEATY 565
            ...:::.||.:.|:..:     .|..| .|....|:..|.....|......|||...:....|..
Mouse   562 TLRKQQQLLAACKSLPS-----SPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEA 621

  Fly   566 GKLFEMATAGS-----SRSNVLTPNQ---VAEQQQLACITEDSELDACEGAVGGVPLPQAVIEEF 622
            ..:..::|.||     .|...|..|:   .||::.|     ||..:. .|:...:|:.|:.:
Mouse   622 AAVAGLSTPGSLHRAAKRRTSLFANRRGSDAEKRSL-----DSRGET-TGSGRAIPIKQSFL--- 677

  Fly   623 DPLSSKCSTLARSNK-------SNELLLLEHLLEEDTYGTVKAEQDDVSMCTSEEEPTTSAATSP 680
              |....::|.:..|       ||..||....:.:..:.|...|.|.:.        ||......
Mouse   678 --LKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLR--------TTVKVPGK 732

  Fly   681 KPQQPQIVHQ-------NARLLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASASRNRT 738
            :|  |:.:..       |. |:.|.....:....|.:.|..|..| |.:....|.|..|     .
Mouse   733 RP--PRAISAFGPSASING-LVKDMSTVQMGEGPEASTPMPSPSP-SPSSLQLPTDQTS-----K 788

  Fly   739 NWFVPD----KASCSDVTPNTSKTTPPIEGDSPPTYLEAIGGSKDAAGNQENRSTIGSRFRQTIN 799
            :...||    :|..:|.||  |....|:..:.||:.:.          .::.|..:.:..:...:
Mouse   789 HLLKPDRNLARALSTDCTP--SGDLSPLSREPPPSPMV----------KKQRRKKLSTPSKTEGS 841

  Fly   800 AI-SNVKLKMDAMKRKASFRGANQRQSDVRVALQMVPRPSLSPLLIRYEGPLVRFPSGVVEDILK 863
            |: :..|.||..:|...|.|...:.:.:...            |::...|....|.:...|:
Mouse   842 AVQAEAKRKMWKLKSFGSLRNIYKAEENFEF------------LIVSSTGQTWHFEAASFEE--- 891

  Fly   864 EMQNRKAILRERQFQTFLDQEMKTPREMIPLDTITTLQCVSNSRV---TDTATHFYCFEITTSQP 925
                     |:...|....|            .:.:|||..:|:|   ||:.:.....: .....
Mouse   892 ---------RDAWVQAIESQ------------ILASLQCCESSKVKLRTDSQSEAVAIQ-AIRNA 934

  Fly   926 KNGNGAGDAMSSNP-----NL--LMTSSSSGNVKQQRVSH-------------------LYGVGK 964
            |..:...|..:.||     ||  |:....|| :.:...:|                   |..:|.
Mouse   935 KGNSTCVDCGAPNPTWASLNLGALICIECSG-IHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGN 998

  Fly   965 ESERGVWMQKILESLT--NSLPVKYTCHYYRAGWCYLKNSITSEWSGTWLVLRKSQRRLIFVS-- 1025
            ::...||     ||.|  .:.|.:.:....|..|                 :|....:|:|::
Mouse   999 DTANRVW-----ESDTRGRAKPTRDSSREERESW-----------------IRAKYEQLLFLAPL 1041

  Fly  1026 ----EANGN-----VEKMDLRKARCIVLKES-----DESIDNLHVESGPMLMIDCPPYAVYMIMS 1076
                |..|.     ||..|: .|..::|..:     |.|:::..:.|...|..:.....:..::.
Mouse  1042 GTTEEPLGRQLWAAVEAQDV-AAVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLL 1105

  Fly  1077 SARETKIWR 1085
            ..||.::||
Mouse  1106 WVRERRVWR 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Agap2	XP_006513621.1	PHA03247	<52..320	CDD:223021	56/290 (19%)
		Centaurin_gamma	401..560	CDD:133303	34/183 (19%)
		PH_AGAP	668..908	CDD:241281	52/309 (17%)
		ArfGap_AGAP	926..1033	CDD:350065	21/130 (16%)
		SelP_N	<1136..1188	CDD:368014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900