Protein Alignment RhoGAP15B and Appl2

DIOPT Version :9

• Sequence 1: NP_573183.2
• Gene: RhoGAP15B / 32686
• FlyBaseID: FBgn0030808
• Length: 1552
• Species: Drosophila melanogaster
• Sequence 2: NP_660255.1
• Gene: Appl2 / 216190
• MGIID: 2384914
• Length: 662
• Species: Mus musculus
• Alignment Length: 637
• Identity: 109/637 - (17%)
• Similarity: 196/637 - (30%)
• Gaps: 220/637 - (34%)

  Fly   546 EEQEGSSSPEPLYANQ-----EATYGKLFEMATAGSSRSNVLTPNQVAEQQQLACITEDSELDAC 605
            ||..|:.:.   |.||     :..||...||..|....|..|.   ..|:|..|....|.|:
Mouse    27 EEDAGTLTD---YTNQLLQAMQRVYGAQNEMCLATQQLSRQLL---AYEKQNFALGKGDEEV--- 82

  Fly   606 EGAVGGVPLPQAVIEEFDPLSSKCSTLARSNKSNELL---------LLEHLLEEDTYGTVKAEQD 661
               :..:.....|::|.:.|.::   ||:......:|         |.|....:|.:|...:|.
Mouse    83 ---ISTLHYFSKVMDELNGLHTE---LAKQLADTMVLPVIQFREKDLTEVSTLKDLFGLASSEH- 140

  Fly   662 DVSMC------------TSEEEPTTSAATSPKPQ------------------------------- 683
            |:||.            .::.|.....|.:.:.|
Mouse   141 DLSMAKYSRLPKKKENEKAKTEIVKEVAAARRKQHLSSLQYYCALNALQYRKRAAMMEPLIGFAH 205

  Fly   684 -QPQIVHQNARLLSDSMENMLDSDQERAKPYLSRMPESANKA---------------SGPVDLAS 732
             |.....:.|.:.|.||:..|.|.::..:.....:...|:|.               :..:|:|:
Mouse   206 GQINFFKRGAEMFSKSMDGFLSSVKDMVQSIQVELEAEADKMRVSQQELLSVSESVYTPDIDVAT 270

  Fly   733 ASRNR-------------------TNW-----------------------FVPDKASCS------ 749
            |..||                   |.|                       .:.|..:||
Mouse   271 AQINRNLIQKTGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDC 335

  Fly   750 -------DVTPNTSKTTPPIEGDSPPTYLE---AIGGSKDAAGNQENRSTIGSRFRQT-INAISN 803
                   .::..:.|....::.:|...|.|   |:..........:|...:..:..|| :.|::
Mouse   336 EDRRYCFQISTPSGKPGIILQAESRKEYEEWICAVNNISRQIYLTDNPEAVAIKLNQTALQAVT- 399

  Fly   804 VKLKMDAMKRKASFRGANQRQSDVRVALQMVPRPSLS------------PLLIRYEGPLVRF--- 853
             .:.....|:::|....|.:.||:... .:||:.:.|            |:......|...|
Mouse   400 -PITSFGKKQESSCSSQNIKNSDIEDD-NIVPKATASIPETEELIAPGTPIQFDIVLPATEFLDQ 462

  Fly   854 --------PSGVVED---------ILKEM-------------QNRKAILRERQFQTFLDQEMKTP 888
                    |.|..||         :|::|             .:...::.|...|....:.:...
Mouse   463 NRGGRRTNPFGETEDGSFPEAEDSLLQQMFIVRFLGSMAVKTDSTAEVIYEAMRQVLAARAIHNI 527

  Fly   889 REMIPLDTITTLQCVSNSRVTDTATHF--YCFEITT-----SQPKNGNGAGDAM----SSNPNLL 942
            ..|.....:.|.|.:   |:.|..|..  .|||:|:     :..:|....|..:    |:....|
Mouse   528 FRMTESHLMVTSQTL---RLIDPQTQVSRACFELTSVTQFAAHQENKRLVGFVIRVPESTGEESL 589

  Fly   943 MTSSSSGNVKQQRVSHLYGVGKESERGVWMQKILESLTN---SLPV----KY 987
            .|.....|.:.:::.:...:|||.   :.:||..|:|..   |:|:    ||
Mouse   590 STYIFESNSEGEKICYAINLGKEI---IEVQKDPEALARLMLSVPLTNDGKY 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Appl2	NP_660255.1	BAR_APPL2	20..234	CDD:153316	42/222 (19%)
		BAR-PH_APPL	252..376	CDD:270067	15/123 (12%)
		PH	278..378	CDD:278594	10/99 (10%)
		PH domain	278..376		10/97 (10%)
		PTB_APPL	480..613	CDD:269980	22/135 (16%)
		PTB domain	491..607		19/118 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..662

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810