DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP15B and Arap2

DIOPT Version :9

Sequence 1:NP_573183.2 Gene:RhoGAP15B / 32686 FlyBaseID:FBgn0030808 Length:1552 Species:Drosophila melanogaster
Sequence 2:NP_848494.2 Gene:Arap2 / 212285 MGIID:2684416 Length:1703 Species:Mus musculus


Alignment Length:1671 Identity:348/1671 - (20%)
Similarity:589/1671 - (35%) Gaps:457/1671 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 LLDQRSSICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSHSGKFKSQS-----PGYVDA- 201
            :|.|...|.|::....:.  ....:.:.||........|.|.|:|:|...|.|     ||...: 
Mouse    60 ILKQLQMIFSKMQDFPIY--ANVHKAKNGSTTKEQQHSDPSSSTHTGIECSDSITVHRPGPAPSE 122

  Fly   202 --VDSSIPQSDHPDPNGHHPQAESS-----SAEQSSGSQDGDDDN-----NLLRSLGTTSKLLGE 254
              ..|::.:.:...|..|.....||     ..|:...:.|...|:     |:......|.:.:..
Mouse   123 MVTTSTLSEGNCQSPKSHDKLCLSSHDLLCPEEELHQNVDSSKDSLFGGVNVKIDPLITKRAVEY 187

  Fly   255 AIGERITFKAKGAKKRLDRNFKSSTEAISNIGADAGRSLKHASKRFGSNFSLGRNKDKADIGIGG 319
            ..||..|.|.....:...:...::||.:.:  .|...|..|:..  |:|..|             
Mouse   188 TAGEEHTEKGNLTSEDSSKALSTNTECLPS--GDCPTSGTHSGN--GTNGVL------------- 235

  Fly   320 RPGGSGEMDLDRRQTMPSTEVFNTIQF------------SSPLNRNGGLPDLRENDAKLQKEDYL 372
                         ::.|.|..|   ||            |||::   |....|..........:|
Mouse   236 -------------ESFPPTPFF---QFQGEMVVNELYVPSSPVH---GPMRSRSKLVSRPSRSFL 281

  Fly   373 ---RPDPDQEDDGCYEVP-KTQGKPPSYDEALRSRPSPSDSPMSRNLAQEAAQLVQLRNQRQLSS 433
               ||.|        |:| .|:..|.||   .|.|.|.:.|         |.:.:.|:|      
Mouse   282 LRHRPVP--------EIPGSTKSIPGSY---FRDRRSNTTS---------AGKSLTLKN------ 320

  Fly   434 SSSNGDESPRLPMPAFPPPRLSQQPEQFRMDALQPPVRQKRRKNYEHIELRRPPVDSAQLEELNR 498
              ||.|.|..:    ||      ..|.|....|:...::..:..:.       |.::...||   
Mouse   321 --SNEDNSTSI----FP------YGETFLFQRLESSKKRSIKNEFW-------PHENTVKEE--- 363

  Fly   499 AAAAAEREESLLISAKNAEAETKTPKPERSDSWEFYGEDENEEEDRDEEQEGSSSPEPLYA---- 559
              ||..|...|..|:.....:.|..:.:..|.|....:..|..:|...|.|.|:..|...:    
Mouse   364 --AATTRNSILTQSSIYDNRKEKVSEDKVEDIWIPREDKNNLAQDSASESEYSTVEECFQSLRRK 426

  Fly   560 --------NQEATYGKLFE------MATAG-----SSRSNVLTP------NQVAEQQ-------- 591
                    .|:|.|...|.      .:|:|     |:.||.::|      :..|:::        
Mouse   427 NSKASKSRTQKAFYLDPFNRHSYPLSSTSGNTEPSSTISNAISPYACFYGSSAAKEKCGWLDKLS 491

  Fly   592 -----------------QLACITEDSELDACEGAVGGVPLPQAVI------EEFDPLSSKCSTLA 633
                             .::....|.|:    .:.|.:||.....      .:|:.::::.:.:.
Mouse   492 PQGKRMFQKRWVKFDGLSISYYNNDREM----YSKGIIPLTAISTVRAQGDNKFEIVTTQRTFVF 552

  Fly   634 RSNKSNE-----LLLLEHL----LEEDTYGTVKAEQ-------------------DDVSMCTSEE 670
            |..|..|     .:||..|    |.......|..|:                   :.|.:|.:|:
Mouse   553 RVEKEEERNDWISILLSALKSPSLASQLQAAVAPEKCGYLELRGYKAKIFTVLRGNSVWLCKNEQ 617

  Fly   671 EPTTSAATSPKPQQPQIVHQNARLLSDSMENM-------LDSDQERAK-PYLSRMPESANKASGP 727
            :..:....:..|.....|.|..|.:..|.|.:       ..:|.||.| .::..:.:|..:....
Mouse   618 DFKSGLGITIIPMNVANVKQVDRAVKQSFEIITPYRSFSFTADSEREKQEWIEAVQQSIAETLSD 682

  Fly   728 VDLASASRNRTNWFVPDKASCSDVTPNTSKTTPPIEGDSPPTYLEAIGGSKDAAGNQENRSTIGS 792
            .::|...     ||.....||:|     .|...|   |.....| .:...|..||...:.....|
Mouse   683 YEVAEKI-----WFNESNRSCAD-----CKAPDP---DWASINL-CVVICKKCAGQHRSLGPKDS 733

  Fly   793 RFRQTINAISNVKLKMDAM---------------KRKASFRGAN-QRQSDVRVALQMVPRPSLSP 841
            :.|         .|||||.               ||...|...| |:..:::|...:..|.:.  
Mouse   734 KVR---------SLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELQVDSPVEKRKNF-- 787

  Fly   842 LLIRY-EGPLVRFPSGVVEDILKEMQNR---KAILRERQFQTFL-------------DQEMKTPR 889
            :..:| ||   :|...::..:.||..|:   .|:::....:|..             |....|| 
Mouse   788 ITQKYKEG---KFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTP- 848

  Fly   890 EMIPLDTITTLQC--VSNSRVTDTATHFYCFEITTSQPKNGN-----------GAGDAMSSNPNL 941
            .::......:||.  :.:::.:|...:...||..:||....:           .|...:||...|
Mouse   849 YLLAKKAGQSLQMEFLYHNKFSDFPQYDAHFEGGSSQDAAQSSFLCDFLYQTAAAASRVSSEKKL 913

  Fly   942 L-----------------------MTSSSSGNVKQ---------------------------QRV 956
            |                       .|.:.:.|:.:                           :||
Mouse   914 LEDTNKKWCVLEGGFLSYYENDRCTTPNGTINISEVICLAVHKEDFYLNTGPIFVFEIYLPSERV 978

  Fly   957 SHLYGVGKESERGVWMQKI--------LESLTNSLPVKYTCHYYRAGWCYLKN-SITSEWSGTWL 1012
             .|:|......:..|.:.|        .|:||.:       .|...|..:.|: ....:|...|.
Mouse   979 -FLFGAETSQIQRKWTETIAKRFVPFVAENLTEA-------DYDLIGQLFYKDCHALDQWRKGWF 1035

  Fly  1013 VLRKSQRRLIF-VSEANGNVEKMDLRKARCIVLK---ESDESID-NLHVESGPMLMIDCPPYAVY 1072
            .:.||.  |.| :.......|:|:||:.:.:.:.   ::.|.:| .|.||.|..|         |
Mouse  1036 AMDKSS--LCFCLQTQEAQEERMNLRRLQELTISTMVQNGEKVDVLLLVEKGRTL---------Y 1089

  Fly  1073 MIMSSARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSE 1137
            :...:..:..:|...|.:.|..:|.:|.||||.:.|||:||:.||.||..:|...:.||:|.|..
Mouse  1090 IHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLCKNDVPIIVNSCIAFVTQYGLGCKYIYQKDGDP 1154

  Fly  1138 NSMHKLMSAFRADAFNVEITRNEYNEHDVANVLKRFMRDLPERLLGK-LTDSFVFVTELAVASEK 1201
            ..:.:|:.:|:.||.:|::...::...||..|||.|:.|:.:.||.| |...:|...:.....|:
Mouse  1155 LHISELLESFKKDARSVKLRAGKHQLEDVTGVLKSFLSDIDDALLTKELYPYWVSALDTQDEKER 1219

  Fly  1202 IPIYRELLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLAKKSDELIYSQKE 1266
            ...||..:..|..:.|.||..::.||..:......|.|:..||.|::...|...|..    :.:|
Mouse  1220 TSKYRAFIRSLPGVNRATLAALIEHLYRVQKCSEINHMNAHNLAMVFSSCLFQTKGQ----TSEE 1280

  Fly  1267 ADVLSDLVVLYKNLFPCSADEIKREQAMLACLQKYYAAAETLKDA-VKQSGDIKIWISLNPNPEN 1330
            .:|:.||:..|..:|....|::|:.....:.:.|:       ||. |.|:||:.|.:.:     .
Mouse  1281 VNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKW-------KDTQVSQAGDLLIEVFV-----E 1333

  Fly  1331 KTEEKTQVNATISPTKTAYELCREYSA-KMQLPTHQ--LTLYEVILNDSLERPLHHDTKVFDVIL 1392
            :.|....:...|||...|.||..:..| |..:|...  ...:|||.|:.||||||:...|.:.:|
Mouse  1334 RKEPDCSIIIRISPVMEAEELTNDILAIKNIIPMKGDIWATFEVIENEELERPLHYTENVLEQVL 1398

  Fly  1393 NWSYWPEEDRKH----NYLVVRPVEMLRE--IQRAVKNLATVTPGKEL---RFADSRTKTFKTLQ 1448
            .||...|....:    .:|.:..::..||  |:..:..|.. .|.|.|   :|.|         :
Mouse  1399 QWSSLAEPGSAYLVVKRFLTIDSIKQCREKSIKEGILKLKE-EPSKILSGNKFQD---------R 1453

  Fly  1449 C-ELRDGKIVVSKKDKNDKTTIVREIF-LQSSTAYLGCERKRDFPWSWAITF----------VER 1501
            | .||||.:.:.|..|:.|..   ::| |::...|||.::|...|.||.:|.          .:.
Mouse  1454 CVVLRDGHLFIYKDPKSSKHD---KMFPLRAMKFYLGVKKKMKPPTSWGLTVYSEKHHWHLCCDS 1515

  Fly  1502 TQAQIMRSRDAPFIGHVLAGSEWGDRTIWYSSIWYCLYRDNILPPA 1547
            .|||:.                      |.:||:...:.::|.|||
Mouse  1516 LQAQME----------------------WMASIFIAQHENDIWPPA 1539

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP15BNP_573183.2 RhoGAP_ARAP 1095..1277 CDD:239850 57/182 (31%)
Arap2NP_848494.2 SAM_Arap1,2,3 6..68 CDD:188889 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 84..132 12/47 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 191..232 9/44 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 286..319 13/52 (25%)
PH1_ARAP 482..573 CDD:270073 12/94 (13%)
PH2_ARAP 583..673 CDD:270074 15/89 (17%)
ArfGap_ARAP2 678..798 CDD:350081 30/147 (20%)
PH3_ARAP 890..1000 CDD:270076 13/110 (12%)
PH-like 1013..1108 CDD:388408 23/105 (22%)
RhoGAP_ARAP 1112..1291 CDD:239850 57/182 (31%)
RA_ARAP2 1323..1420 CDD:340747 29/101 (29%)
PH-like 1426..1537 CDD:388408 34/145 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1633..1670
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1684..1703
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 104 1.000 Domainoid score I6683
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001278
OrthoInspector 1 1.000 - - otm44184
orthoMCL 1 0.900 - - OOG6_104434
Panther 1 1.100 - - O PTHR45899
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1129
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1110.770

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