DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and Asap2

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_006515110.1	Gene:	Asap2 / 211914	MGIID:	2685438	Length:	1003	Species:	Mus musculus

Alignment Length:	786	Identity:	149/786 - (18%)
Similarity:	263/786 - (33%)	Gaps:	265/786 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 DDE----VPLR-ILRAAPQIPPKPLNILLDQRSSICSEVSTTSVQTPGKADE---DREGSRYASN 177
            |:|    :.|| ||::|.|:..|.     .:|.|...:.:..|:..|....|   :|.|:.|..:
Mouse   260 DEERRQLIQLRDILKSALQVEQKE-----SRRDSQLRQSTAYSLHQPQGNKEHGTERNGNLYKKS 319

  Fly   178 ASL-------DCSES------SHSGKFKSQSPGYVDAVDSSIPQSDHPD----------PNGHHP 219
            ..:       .||..      ||.  ..::.|..::.:...:  ..:|:          ...:|.
Mouse   320 DGIRKVWQKRKCSVKNGFLTISHG--TANRPPAKLNLLTCQV--KTNPEEKKCFDLISHDRTYHF 380

  Fly   220 QAE-------------SSSAEQSSGSQDGDD---DNNLLRSLGTTSKLLGEAIGERITFKAKGAK 268
            |||             :|..|..:.:..|||   :||:::.|  |.:::.|.  :|:|    |..
Mouse   381 QAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQEL--TKEIISEV--QRMT----GND 437

  Fly   269 KRLDRNFKSSTEAISNIGADAGRSLKHASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQ 333
            ...|......|...:|:|...........:..|.::|                         |.|
Mouse   438 VCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYS-------------------------RMQ 477

  Fly   334 TMPSTEVFNTIQFSSPLN-RNGGLPDLRENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKPPSYD 397
            :: :.:|..|.:.....| .|.|..::.|  ..|..||.::|:|     |...:.:.......|.
Mouse   478 SL-TLDVLGTSELLLAKNIGNAGFNEIME--CCLPSEDPVKPNP-----GSDMIARKDYITAKYM 534

  Fly   398 EALRSRPSPSDSPMSRNLAQEAAQLVQLRNQRQLSSSSSNG-DESPRLPMPAFPPPRLSQQPEQF 461
            |...:|...:|:....:...||   |:.|:...|..:.::| |.:.::|:..      ..:|::
Mouse   535 ERRYARKKHADTAAKLHSLCEA---VKTRDIFGLLQAYADGVDLTEKIPLAN------GHEPDE- 589

  Fly   462 RMDALQPPVRQKRRKNYEHIELRRPPVD-----SAQLEELNRAAAAA-------EREE--SLLIS 512
              .||...||...|.:. ||      ||     |..|::.....:.|       :..|  .||:.
Mouse   590 --TALHLAVRSVDRTSL-HI------VDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 645

  Fly   513 AK------NAEAET-----KTPKPERSD-------------------SWEFYGEDENEEEDRDEE 547
            .|      |...||     |..|.|..:                   .|....||.:|.:| |.:
Mouse   646 GKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDD-DVD 709

  Fly   548 QEGSSSPEPLYANQEATYGKLFEMATAGSSRSNVLTPNQVAEQQQLACITEDSELDACEGAVGGV 612
            ::...||.    .:|......:::   |||:   ...|.|:..:..|.:|:|.:
Mouse   710 EKLQPSPN----RREDRPVSFYQL---GSSQ---FQSNAVSLARDTANLTKDKQ----------- 753

  Fly   613 PLPQAVIEEFDPLSSKCSTLARSNKSNELLLLEHLLEEDTYGTVKAEQDDVSMCTSEEEPTTSAA 677
                   ..|.|                     .:|:.:|||.:.:.    |..:|:..|.::.:
Mouse   754 -------RGFGP---------------------SILQNETYGAILSG----SPPSSQSIPPSTTS 786

  Fly   678 TSPKPQQPQIVHQNARLLSDSMENML----------------DSDQERAKPYLSRM--------- 717
            ..|.|  |:.|   .::.:.:..|.|                .||.....|.|..:
Mouse   787 APPLP--PRNV---GKVQTATSANTLWKTNSVGVDGISRQRSSSDLPAVHPPLPPLRVTSTNPLT 846

  Fly   718 ---PESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNTSKTTPPIEGDSPPTYLEAIGGSKD 779
               |....|.||.::..:.         |.|:|    .|.||::.||.....||:.|..   .|.
Mouse   847 TTPPPPVAKTSGTLEAMNQ---------PSKSS----QPGTSQSKPPPLPPQPPSRLPQ---KKP 895

  Fly   780 AAGNQE 785
            |:|..:
Mouse   896 ASGTDK 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
Asap2	XP_006515110.1	BAR_ASAP2	34..248	CDD:153326
		PH_ASAP	300..406	CDD:270071	17/109 (16%)
		ArfGap_ASAP2	422..544	CDD:350074	29/162 (18%)
		ANK repeat	553..585	CDD:293786	8/40 (20%)
		ANK repeat	589..621	CDD:293786	11/41 (27%)
		Ank_2	592..676	CDD:372319	21/90 (23%)
		ANK repeat	623..654	CDD:293786	5/30 (17%)
		SH3_ASAP2	945..1000	CDD:212899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810