DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and rga-5

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_001023257.1	Gene:	rga-5 / 178348	WormBaseID:	WBGene00010374	Length:	1341	Species:	Caenorhabditis elegans

Alignment Length:	998	Identity:	194/998 - (19%)
Similarity:	339/998 - (33%)	Gaps:	283/998 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   434 SSSNGDESPRLPMPAFPPPRLSQQPEQFRMDALQPPVRQKRRKNYEH------------------ 480
            ||.|.||..|||......|..::..||||:..|...::.:..:.:|:
Worm   411 SSFNKDEKSRLPSEILLLPEAAKVFEQFRLSTLNLRLKHQLGQEFEYLLNEIPQILPGCSMETAF 475

  Fly   481 --------IELRRPPVDSAQLEELNRAA---AAAEREESLL-----ISAKNAEAET-KTPKPERS 528
                    |:...|.:.:...:...:..   |..:.||.:|     |..:|.:.:: |||.....
Worm   476 PLFQNFNVIKKLTPDIVTTVYDRFQKKLMENARKQLEECILEVSPGIQLQNLKIKSWKTPGLSHF 540

  Fly   529 D-SWEFYGEDEN-----EEEDRDEEQEGSSSPEPLYANQEATYGKLFEMATAGSSRSNVLTP--- 584
            | |.:|..:.|.     |.:||.|.....:............:  :|:::......:::...
Worm   541 DMSMDFNQKLETVKNFLEVDDRYEWMRIMAGERDQIIVNHLPF--IFDVSPVNCPSTDMCIDLVG 603

  Fly   585 ----NQVAEQQQLACITEDSELDACEGAV---GGVPLPQAVIE-------EFDPLSSKC--STLA 633
                |..:||....|  ..|....|..|.   .|..:|:..|.       ..|.|:...  :||.
Worm   604 TSILNDFSEQNSTFC--GSSGFSECFEATRKNSGKNMPRIQISAMCGDQLSIDSLAGALFHNTLI 666

  Fly   634 RS---NKSNELLLLEHLLEEDT--YGTVKAEQDDVSMCTSEEEPTTSAATSPKPQQPQIVHQNAR 693
            |.   |.||:......:|:|:|  :..:     :::||:..                ...|:|..
Worm   667 RPSNYNFSNDGATFIEVLDENTQIWNNI-----EINMCSYH----------------SWFHKNDS 710

  Fly   694 LLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNTSKT 758
            ..|:|    :|.:......|.|:...|.|.|...:: ..|..|..|:      .|
Worm   711 NPSES----IDLNDGYLFVYNSQRASSFNYARCAIE-KLAETNSVNF------DC---------- 754

  Fly   759 TPPIEGDSPPTYLEAI---GGSKDAAGNQENRS-------TIGSRFRQTINAISNVKLKMDAMKR 813
                      ..|.|:   |||.....|.||.:       :||:||    :||       |..||
Worm   755 ----------ILLLAVVKGGGSDSMKLNLENLTEGAELCKSIGARF----SAI-------DFRKR 798

  Fly   814 KASFRGANQRQSDVRVALQMVPRPSLSPLL---------IRYEGPLVRFPSGVVEDILKEMQNR- 868
            |....|.|.:..:.   |..:....:.|:.         |..:.|.:...||:......:..||
Worm   799 KTKSNGINHQMMEF---LHDICDGQVQPITSNANSEIDSIENDRPSILSSSGIQLLAKPDSSNRS 860

  Fly   869 -------KAILRERQFQT-------FLDQEMK--------------TPREMIPLDTITTLQCVSN 905
                   .:.||.|..:|       |..|.::              :|...:..|.:.|:..|:.
Worm   861 RRPKPVVNSNLRNRVTRTDPLIMSHFYSQPIEIQPAPLATPEAVDFSPAYSLVNDAVHTVIQVNG 925

  Fly   906 SRVTDTATHFYCFEITTSQPKNGNGAGDAMSSNPNLLMTS----SSSGNV--------KQQRVSH 958
            |....:...|:.:|.:|...::........|..|..:...    |.:.||        :..|.|:
Worm   926 STPLKSPPTFHSYESSTPDSRSTTSTVSGSSPAPRAVSADVTRRSRTSNVSLSTDSINRLHRTSN 990

  Fly   959 LYGVGKESERGVWMQK---ILESLTNSLPVKYTCHYYRAGWCYLKNSITSEWSGTWLVLRKSQRR 1020
            |:.:..|:......::   .:|||| .:|.|      ..|..:::...||      ..||||
Worm   991 LFQLRPEAALTAEQKRKSLSIESLT-KVPEK------EKGNRFVRKVATS------FRLRKS--- 1039

  Fly  1021 LIFVSEANGNVEKMDLRKARCIVLKESDES--IDNLHVESGPMLMIDCPPYAVYMIMSSARE--- 1080
             :..:..:|..:|.:.:|...........|  ::.:...|.|..........:|..::|..|
Worm  1040 -LLDTTCDGESDKKENKKKTSTTTSPEQISSFLEKMATRSLPQSPRTDRKAKLYSSLNSTTEKVS 1103

  Fly  1081 -------TKIWRHIIREVAHNNGFSLGDQQLTRY-------------------------DVPVIV 1113
                   :|..:.:::..:..:..|   ..|..|                         .:|:.:
Worm  1104 NVLSWLPSKTSKKLMKNKSATHDLS---TSLINYPASTSTQGVIAANETLETLCSKSPSQIPIYL 1165

  Fly  1114 DKCINFVYIHGSM-SEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHDV----------A 1167
            :|||.|:..:|.. .||:||..|::..:.::...|.           :|.|.||          |
Worm  1166 EKCIQFIEQNGGFEQEGLYRVPGNQTHLAEVEKRFL-----------KYGEFDVSSFDTPVHVAA 1219

  Fly  1168 NVLKRFMRDLPERLLGKLTDSFVFVTELAVASE---KIPIYRELLARLSAIERETLRRIVGHLVF 1229
            ..||.|...|||.|:.  |...:...::.:.|:   ||...|:.||.|....::.|:.:|.||..
Worm  1220 TALKSFFSCLPESLIP--TAYHLRWKQIMMVSDDIKKIDGIRDALAILPVSNQKVLQYLVTHLTK 1282

  Fly  1230 ISSQQAKNKMSVQNLTMIWGPTL 1252
            :|. ..|..|:..||:.:|.|||
Worm  1283 VSC-SPKTVMNSNNLSKVWTPTL 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	48/197 (24%)
rga-5	NP_001023257.1	Ras_like_GTPase	<164..257	CDD:206648
rga-5	NP_001023257.1	RhoGAP	1141..1332	CDD:383032	45/178 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159177
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930