DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and cnt-1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_001369802.1	Gene:	cnt-1 / 174848	WormBaseID:	WBGene00000565	Length:	826	Species:	Caenorhabditis elegans

Alignment Length:	684	Identity:	138/684 - (20%)
Similarity:	229/684 - (33%)	Gaps:	212/684 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 STTSVQTPGKADEDRE-----GSRYASNASLDCSESSHSGKFKSQSPGYVDAVDSSIPQSDHPDP 214
            ::.|.|.|..|.|.|.     |:.:| :.:||                ||..::.:....||...
Worm   155 ASISRQKPADATEGRNALTAVGTCFA-HTTLD----------------YVANINIAHAHKDHMIL 202

  Fly   215 NGHHPQAESSSAEQSSGSQDGDD----DNNLLRSLGTTSKLLGEAIGERI-TFKAKGAKKRLDRN 274
            :........|||..|.|....|:    ||.              ||.:.| ||.||  .|.::|.
Worm   203 DALWTLVRESSAFFSKGHATFDEWTAADNG--------------AIADTIQTFAAK--SKLIERK 251

  Fly   275 FKSSTEAISN----------IGADA---GRSLKHASKRFGS-NFSLGRNKDKADIGIGGRPGGSG 325
            .:.....:..          |..|.   |...|.:|..|.: |....:.|||
Worm   252 MQDVHSLVPKEMFQHPSGMPIEPDVMMEGYLYKRSSNAFKTWNRRWFQIKDK------------- 303

  Fly   326 EMDLDRRQT--MPSTEVFNTIQF------SSPLNRNGGLP-------DLRENDAKLQKEDYLRP- 374
            ::....|.|  .|:|.:...::.      .|.::|.|...       .|.:.|::...:|::|.
Worm   304 QLLYSHRSTDLEPATIMEENLRICLVRPAPSNIDRIGCFELVTPTRIHLLQADSESLCQDWMRAL 368

  Fly   375 --------DPDQEDDGCYEVPKT--QGKPPSYDEALRSRPSPSDSPMS--------RNLAQEA-- 419
                    :.|..|     |..|  :.|..|....:....:.:.||:|        |:::..|
Worm   369 QRTILALHEGDSVD-----VASTSPRNKTTSMSSGVTLTSANAISPLSNAMDVTKGRSVSDPAST 428

  Fly   420 ---AQLVQLRNQRQLSSSSSNGDESPRLPMP------AFPPPR--------------------LS 455
               |....:......|||::..::..|:|..      ..|.|:                    |.
Worm   429 YTSANTSSISTAAGFSSSTTAFEQVRRVPGNEVCADCGSPAPKWVSINLGVVLCIECSGAHRSLG 493

  Fly   456 QQPEQFR---MDALQPPVRQ------KRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLI 511
            .|..:.|   ||::...:|.      .|:.| |......||.||....::|..:|...||  ..|
Worm   494 VQTSKVRSLCMDSIDNELRDVLLALGNRQVN-EIFLAHLPPADSIVPPQINEKSARPARE--AWI 555

  Fly   512 SAKNAEAETKTPKPERSDSWEFYGEDENEEEDRDEEQE--GSSSPEPL-----YAN-QEATYGKL 568
            .||..|......:..|:.|     ...|.:|....:..  |:||...:     ||: |:|..|.|
Worm   556 KAKYVERRFAVAEDTRARS-----SATNRQEHLKHKTSIGGNSSSNGVNRSSSYADVQDAESGGL 615

  Fly   569 FEMATAGSSRSNVLTPNQVAEQQQLACITEDSELDACEGAVGGVPLPQAVIEEFDPLSSKCSTLA 633
            .:   |....:::..|...|.::..|| ..|:.||    |:|...:....: |:|.:...|
Worm   616 LD---ADPWSADLSVPVPTASKRLSAC-GSDTNLD----AIGSSSIDTKTV-EWDSVKEAC---- 667

  Fly   634 RSNKSNELLLLEHLLEEDTYGTVKAEQDDVSMCTSEEEPTTSAATSPKPQQPQIVHQNARLLSDS 698
               :..:||.|.         |..|:..|::   :....||:...:.:..|...|  ...||:.:
Worm   668 ---ECGDLLALM---------TAYAQGFDLN---ALHNGTTALHIATRNGQTAAV--EFLLLNGA 715

  Fly   699 MENMLDSDQERAKPYLSRMPESANKASGPVDLAS 732
            ..||||                 .|.:.|:.||:
Worm   716 KINMLD-----------------EKLNTPLHLAA 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850
cnt-1	NP_001369802.1	BAR_ACAPs	30..233	CDD:153287	22/108 (20%)
		PH_ACAP	278..377	CDD:270070	19/111 (17%)
		ArfGap_ACAP	447..565	CDD:350064	25/120 (21%)
		PTZ00322	628..>795	CDD:140343	32/149 (21%)
		ANK repeat	690..721	CDD:293786	8/32 (25%)
		Ank_2	695..775	CDD:403870	12/57 (21%)
		ANK repeat	723..754	CDD:293786	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910