DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and Acap3

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_997106.1	Gene:	Acap3 / 140500	MGIID:	2153589	Length:	833	Species:	Mus musculus

Alignment Length:	350	Identity:	67/350 - (19%)
Similarity:	127/350 - (36%)	Gaps:	97/350 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1030 NVEKMDLRKARCIVLKESDESIDNLHVESGPMLMIDCPPYAVYMIMSSARETKIWRHIIREVAHN 1094
            |..|.|:||     .||:.:..|.:..:               |.:|..|..:..||...||...
Mouse   109 NFVKEDVRK-----FKETKKQFDKVRED---------------MELSLVRNAQAPRHRPHEVEEA 153

  Fly  1095 NGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRN 1159
            .|      .||      :..||...:.:...:...:.:.......:..::|...|
Mouse   154 TG------ALT------VTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHA---------- 196

  Fly  1160 EYN----EHDVANVLKRFMRDLPERLLGKLTDSFVFVTELAVASEKIPIYRELLARLSAIERETL 1220
            :|:    .:.:.:.|..:|:.|...|...:.||         |.||    ||:..:.:||::.||
Mouse   197 QYSFFQQGYSLLHQLDPYMKKLAAELDQLVIDS---------AVEK----REMERKHAAIQQRTL 248

  Fly  1221 RRIVGHLVFISSQQAKNKMSV----------------QNLTMIWGPTLLAKKSDELIYSQKEADV 1269
                  |...|..:.|.:..|                .|....|.....:.::.:|:|.:|..|.
Mouse   249 ------LQDFSYDEPKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDA 307

  Fly  1270 LSDLVVLYKNLFPCS---ADEIKRE------QAMLACLQKYYAAAETLKDAVKQSGDIKIWISLN 1325
            |:   |:..:|..||   .::|:|.      ....:|:.:  |.:|.|:.|..|:....|..:..
Mouse   308 LT---VVVDDLRLCSVKPCEDIERRFCFEVVSPTKSCMLQ--ADSEKLRQAWVQAVQASIASAYR 367

  Fly  1326 PNPENKTEEKTQVNATISPTKTAYE 1350
            .:|::...|:  ::.|.||:.::.:
Mouse   368 ESPDSCYSER--LDRTASPSTSSID 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	35/201 (17%)
Acap3	NP_997106.1	BAR_ACAP3	16..215	CDD:153321	24/147 (16%)
		PH	269..363	CDD:278594	19/98 (19%)
		PH_ACAP	271..367	CDD:270070	20/100 (20%)
		ArfGap	403..521	CDD:279720
		ANK	671..786	CDD:238125
		Ank_2	671..764	CDD:289560
		ANK repeat	700..731	CDD:293786
		ANK repeat	733..764	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810