DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP15B and AGAP3

DIOPT Version :9

Sequence 1:NP_573183.2 Gene:RhoGAP15B / 32686 FlyBaseID:FBgn0030808 Length:1552 Species:Drosophila melanogaster
Sequence 2:NP_114152.3 Gene:AGAP3 / 116988 HGNCID:16923 Length:911 Species:Homo sapiens


Alignment Length:692 Identity:145/692 - (20%)
Similarity:212/692 - (30%) Gaps:243/692 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 PNSPSNNINHNNIKKLNINAENLHGNCAEKKLPSSGQNKLILQENNSDSQQPIYGPDANENVQEP 94
            |||||    |:.:...:|.|.:::                  |..|.       |..|..:....
Human   303 PNSPS----HSAVSAASIPAVHIN------------------QATNG-------GGSAFSDYSSS 338

  Fly    95 VYATPRPAPRQRLPPAGEPEDSYPDPDDEVPLRILRAAPQIPPKPLNILLDQRSSICSEVSTTSV 159
            |.:||..:.|:                    |||...|....|.|:.....:||:|.        
Human   339 VPSTPSISQRE--------------------LRIETIAASSTPTPIRKQSKRRSNIF-------- 375

  Fly   160 QTPGK-ADEDREGSRYASNASLDCSES------------SHSGKF--KSQSPGYVDAVDSSIPQS 209
             |..| ||.|||  :.|:...:|...|            ..|||.  |.....||...|      
Human   376 -TSRKGADLDRE--KKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCD------ 431

  Fly   210 DHPDPNG---HHPQAESSSAEQSSGSQDGDDDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRL 271
                 ||   :||......  |:...::.|    |||   ||.|:.|:.:.......|.|...|.
Human   432 -----NGLLTYHPSLHDYM--QNIHGKEID----LLR---TTVKVPGKRLPRATPATAPGTSPRA 482

  Fly   272 DRNFKSSTEAISNIGADAGRSLKHASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMP 336
            :                 |.|::.      ||..||              ||:|         .|
Human   483 N-----------------GLSVER------SNTQLG--------------GGTG---------AP 501

  Fly   337 STEVFNTIQFSSPLNRN---GGLPD-LRENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKPPSYD 397
            .:....::....||:.:   |..|: |.:....:.       ..||..:....:|.....|.|..
Human   502 HSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVS-------SADQWSEATTSLPPGMQHPASGP 559

  Fly   398 -EALRSRP--SPSDSPMSRNLAQEAAQLVQLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQPE 459
             |.|.|.|  .|..||.|              |:::.....|.|     .|.|..|.....:..|
Human   560 AEVLSSSPKLDPPPSPHS--------------NRKKHRRKKSTG-----TPRPDGPSSATEEAEE 605

  Fly   460 QFR--MDALQPPVRQKRRKNYEHIELRRPPVDSAQLEELNRAAAAAEREESLLISAKNAEAETKT 522
            .|.  :.:|............|..||.   |.|.|.:.|.........::...:..:||....:.
Human   606 SFEFVVVSLTGQTWHFEASTAEERELW---VQSVQAQILASLQGCRSAKDKTRLGNQNAALAVQA 667

  Fly   523 PKPERSDSWEFYGEDENEEEDRDEEQEGSSSPEPLYANQEATYGKLFEMATAGSSR------SNV 581
            .:..|.:|:..         |.|       :|.|.:|:  ...|.|..:..:|..|      |.|
Human   668 VRTVRGNSFCI---------DCD-------APNPDWAS--LNLGALMCIECSGIHRHLGAHLSRV 714

  Fly   582 LT-------PNQVAEQQQLACITEDSELDACEGAVGGV--PLPQAVIEEFD-------------- 623
            .:       |..:|....:.....:|   ..|||:||.  |.|.|..||.:              
Human   715 RSLDLDDWPPELLAVMTAMGNALANS---VWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLA 776

  Fly   624 PLSSK----CSTLARSNKSNELLLLEHLL-----EE--DTYG 654
            ||.|.    ...|.|:...::|.||..||     ||  :|||
Human   777 PLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYG 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP15BNP_573183.2 RhoGAP_ARAP 1095..1277 CDD:239850
AGAP3NP_114152.3 small_GTPase 126..291 CDD:197466
Centaurin_gamma 128..285 CDD:133303
PH_AGAP 401..645 CDD:241281 67/338 (20%)
PH 404..>465 CDD:278594 19/80 (24%)
ArfGap 664..778 CDD:279720 26/134 (19%)
Ank_2 789..879 CDD:289560 12/30 (40%)
ANK 789..>878 CDD:238125 12/30 (40%)
ANK repeat 789..819 CDD:293786 12/30 (40%)
ANK repeat 821..852 CDD:293786
ANK repeat 854..879 CDD:293786
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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