DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP15B and AGAP1

DIOPT Version :9

Sequence 1:NP_573183.2 Gene:RhoGAP15B / 32686 FlyBaseID:FBgn0030808 Length:1552 Species:Drosophila melanogaster
Sequence 2:XP_006712302.2 Gene:AGAP1 / 116987 HGNCID:16922 Length:1151 Species:Homo sapiens


Alignment Length:1476 Identity:266/1476 - (18%)
Similarity:433/1476 - (29%) Gaps:550/1476 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 ANENVQEPVYATPRPAPRQ-----------RLPPAGEPEDSYPDPDDEVPLRILRAAPQIPPKPL 140
            :.|....|..|.||..|.:           |......|....|||.   |:|        .|:| 
Human     7 SGEPASPPADAMPRGTPPRKTVYRISVTMVRKEQLAAPGSGGPDPR---PVR--------RPRP- 59

  Fly   141 NILLDQRSSICSEVSTTSVQTPGKADEDREGSRYASNASLDCSESSHSGKFKSQSPGYVD--AVD 203
                           ..|...||:.:|:.|.:..|.........:.....|:::|.|.::  .:.
Human    60 ---------------ARSPDAPGRLEEEAEEAEGAEEPEGPRPRAWDFRTFRTRSTGQLELGRLR 109

  Fly   204 SSIPQSDHPDPNGHHPQAESSSAEQSSGSQDGDDDNNLLRSLGTTSKLLGEAIGERITFKAKGAK 268
            ......:..|..|..|..|......:|||.|.:.                          |:.|.
Human   110 PCARGLEPADLAGSAPAEEEGRGSPASGSPDVEG--------------------------ARAAP 148

  Fly   269 KRLDRNFK--SSTEAISNIGADAGRSLKHASKRFGSNFSLG-RNKDKADIGIGGRPGGSGEMDLD 330
            .|...:|:  |..|      |..||:| ...:|..|:.||. ...|:|..|....|..:      
Human   149 LRRSLSFRHWSGPE------APQGRTL-GGGRRHSSSGSLAWAPCDEAAAGTTLEPATA------ 200

  Fly   331 RRQTMPSTEVFNTIQFSSPLNRNGGLPDLRENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKPPS 395
               |.|::|..||:.....|::|..|.||...:....|...|    |..|               
Human   201 ---TQPASEKRNTLDVGEVLSKNDALSDLERWERSKSKNRTL----DNSD--------------- 243

  Fly   396 YDEALRSRPSPSDSPMSRNLAQEAAQLVQLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQPEQ 460
            .....|:|.:......|.:           |..|..|...:..|..|    ...|.||..     
Human   244 LQRLERARAAAGAGAASEH-----------RLLRFFSGIFARRDGGP----GGGPSPRSG----- 288

  Fly   461 FRMDALQPPVRQKRRKNYEHIELRRPPVD--SAQLEELN----RAAAAAEREESLLISAKNAE-- 517
                       ..|.:.|  ..|||.|.:  |:..|.::    |.|....:|.:|..|....:  
Human   289 -----------ASRPRGY--FSLRRAPAEAHSSSAESIDGSPRRDAFVNSQEWTLSRSVPELKVG 340

  Fly   518 -----AETKTPKPERSDSWEFYGEDENEEED--------------------RDEEQEGSSSPEPL 557
                 |..|:....|..:..:..|:..|:.|                    |||    ...||..
Human   341 IVGNLASGKSALVHRYLTGTYVQEESPEDMDAGGRFKKEIVVDGQSYLLLIRDE----GGPPEAQ 401

  Fly   558 YA------------NQEATYGKLFEMATAGSSRSNVLTPNQVAEQQQLACITEDSELDACEGAVG 610
            :|            ..|.::..::..                  ..::|.....||         
Human   402 FAMWVDAVIFVFSLEDEISFQTVYHY------------------YSRMANYRNTSE--------- 439

  Fly   611 GVPLPQAVIEEFDPLSSKCSTL---ARSNK-SNELLLLEHLLEEDTYG----------------T 655
               :|..::...|.:||....:   ||:.| ||:|....:.....|||                |
Human   440 ---IPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNVERVFQDVAQKIVAT 501

  Fly   656 VKAEQDDVSMCTS-EEEPTTSAATSPKPQQPQIVH-----QNARLLSDSMENMLDSDQERAKPYL 714
            .|.:|..:..|.| ...|:.|:..|   .|...||     .....|||...::..:.....|...
Human   502 RKKQQLSIGPCKSLPNSPSHSSVCS---AQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELR 563

  Fly   715 SRMPESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNTSKTTPPIEGDSPPTYLEAIGGSKD 779
            ..:|.:||.   |..:...|:.|:|.|...|.|..|                           |:
Human   564 IDVPPTANT---PTPVRKQSKRRSNLFTSRKGSDPD---------------------------KE 598

  Fly   780 AAGNQENRSTIGSRFRQTINAISNVKLKMDAMKRKASFRGANQRQSDVRVALQMVPRPSLSPLLI 844
            ..|.:....:|||.        ..:.:| ..|..|.|.:..|:......|.|             
Human   599 KKGLESRADSIGSG--------RAIPIK-QGMLLKRSGKSLNKEWKKKYVTL------------- 641

  Fly   845 RYEGPLVRFPSGVVEDILKEMQNRKAILRERQFQTFLDQEMKTPREMIPLDT------------- 896
            ...|.|...||  :.|.::.:..::..|        |...:|.|.:..|..|             
Human   642 CDNGVLTYHPS--LHDYMQNVHGKEIDL--------LRTTVKVPGKRPPRATSACAPISSPKTNG 696

  Fly   897 ----ITTLQCVSNSRVTDTAT--------------------HFYCFEITT------------SQP 925
                :::|....||....:|:                    |...:.:::            |..
Human   697 LSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSAI 761

  Fly   926 KNGNGAGDAMSSNPNLLMTSS--------------------SSGNVKQQRVSHLYGVGKESERGV 970
            .:..|.||::.|:|::..|:|                    |:.|.|...:|   |.. |::|..
Human   762 SSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLS---GTA-EAKRKA 822

  Fly   971 W-------MQKILESLTNS---------LPVKYTCHYYRAGWCYLKNSITSEWSGTWLVLRKSQ- 1018
            |       ::.|..|.||:         :.|..|      |..:...:.|.|....|:...:|| 
Human   823 WKLNRVGSLRNIYSSSTNTEEQEENFEFIIVSLT------GQTWHFEATTYEERDAWVQAIESQI 881

  Fly  1019 -------------RRLIFVSEANGNVEKMDLR-KARCIVLKESDESIDNLHVESGPMLMIDCPPY 1069
                         .||...|||.......::| .:.|:..:..:.:..:|::  |.::.|:|   
Human   882 LASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNL--GALMCIEC--- 941

  Fly  1070 AVYMIMSSARETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKS 1134
                   |.....:..|:.|.           :.|...|.||.:.|.::.:              
Human   942 -------SGIHRNLGTHLSRV-----------RSLDLDDWPVELIKVMSSI-------------- 974

  Fly  1135 GSE--NSMHKLMSAFRADAFNVEITRNE--------YNEHDVANVLKRFMRDLPERLLGKLTDSF 1189
            |:|  ||:.:..|..|... :|:.||.|        |.:       |.|:..||           
Human   975 GNELANSVWEESSQGRTKP-SVDSTREEKERWIRAKYEQ-------KLFLAPLP----------- 1020

  Fly  1190 VFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVFISSQQAKNKMSVQNLTMIWGPTLLA 1254
              .|||::...          .|.|...|.||..:                          .|||
Human  1021 --CTELSLGQH----------LLRATADEDLRTAI--------------------------LLLA 1047

  Fly  1255 KKS-DELIYSQKEAD--------------VLSDLVVLYKNLFPCSADEIKRE---QAMLACLQKY 1301
            ..| ||:..:..|.|              ||:.|::.|      ..|...|:   ...||..:: 
Human  1048 HGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWY------GVDVTARDAHGNTALAYARQ- 1105

  Fly  1302 YAAAETLKDAVKQSG--DIKIWISLNPNPENKTEEKTQVNATISPT 1345
             |:::...|.:.|.|  |.:..:...||...:...:...:..: ||
Human  1106 -ASSQECIDVLLQYGCPDERFVLMATPNLSRRNNNRNNSSGRV-PT 1149

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP15BNP_573183.2 RhoGAP_ARAP 1095..1277 CDD:239850 39/206 (19%)
AGAP1XP_006712302.2 Centaurin_gamma 337..498 CDD:133303 29/194 (15%)
RAS 338..504 CDD:214541 30/199 (15%)
PH_AGAP 613..886 CDD:241281 51/306 (17%)
PH 616..>680 CDD:278594 16/87 (18%)
PH <830..881 CDD:278594 11/56 (20%)
ArfGap 905..1019 CDD:279720 27/158 (17%)
Ank_2 1030..1120 CDD:289560 24/123 (20%)
ANK 1030..>1119 CDD:238125 24/122 (20%)
ANK repeat 1062..1093 CDD:293786 6/36 (17%)
ANK repeat 1095..1120 CDD:293786 5/26 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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