DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP15B and ARAP1

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	NP_001035207.1	Gene:	ARAP1 / 116985	HGNCID:	16925	Length:	1450	Species:	Homo sapiens

Alignment Length:	1714	Identity:	335/1714 - (19%)
Similarity:	573/1714 - (33%)	Gaps:	551/1714 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PVPAPRRLYPELRPANYENIEIRRPNSPSNNINHNNIKKLNINAENLHGNCAEKKLPS------- 63
            |.||||   |..||...:....|.|..|:.            ..|.|.....::.||:
Human    71 PAPAPR---PTPRPVPMKRHIFRSPPVPAT------------PPEPLPTTTEDEGLPAAPPIPPR 120

  Fly    64 -SGQNKLILQENNSDSQQPIYGP-DANENVQE----PVYATPRPAPRQRLP--PAGEPE------ 114
             |..........::.:..|:..| .|..::.|    ||  .||..|.:.|.  |..|.|
Human   121 RSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPV--PPRTGPPRLLVSLPTKEEESLLPSL 183

  Fly   115 DSYPDPDDEVPLRIL-----------RAAPQIPPKPLNILLDQRSSICSEVSTTSVQTPGKADED 168
            .|.|.|..|.||..|           ...|:|||||:.:.                  |...|.|
Human   184 SSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLF------------------PEFDDSD 230

  Fly   169 REGSRYASNASLDCSESSHSGKFKSQSPGYVDAVDSSIPQSDHPDPNGHHPQAES-----SSAEQ 228
            .:                   :...:.||   |....:.:.:.|.|: ..|:|..     |..|:
Human   231 YD-------------------EVPEEGPG---APARVMTKKEEPPPS-RVPRAVRVASLLSEGEE 272

  Fly   229 SSGSQDGDDDNNLLRSLGTTSKLLGEAIGERITFKAKGAKKRLDRNFKSSTEAISNIGADAGRSL 293
            .||...||::.:                               |..:    |.:.|    .|...
Human   273 LSGDDQGDEEED-------------------------------DHAY----EGVPN----GGWHT 298

  Fly   294 KHASKRFGSNFSLGRNKDKADIGIGGRPGGSGEMDLDRRQTMPSTEVFNTIQFSSPLNRNGGLPD 358
            ...|....|..:.....|       |.|||             ||.|       :|:.:.|.|..
Human   299 SSLSLSLPSTIAAPHPMD-------GPPGG-------------STPV-------TPVIKAGWLDK 336

  Fly   359 LRENDAKLQKEDYLRPDPDQEDDGCYEVPKTQGKPPSYDEALRSRPSPSDSPMSRNLAQEAAQLV 423
            .....:.:.::.::|.|.|.                     ||...|..|:...|.::......|
Human   337 NPPQGSYIYQKRWVRLDTDH---------------------LRYFDSNKDAYSKRFISVACISHV 380

  Fly   424 QLRNQRQLSSSSSNGDESPRLPMPAFPPPRLSQQPEQFRMDALQPPVRQKRRKNYEHIELRRPPV 488
            .....::....::|...:.|..         |....:..|.|||..:.::|
Human   381 AAIGDQKFEVITNNRTFAFRAE---------SDVERKEWMQALQQAMAEQR-------------- 422

  Fly   489 DSAQLEELNRAAAAAEREESLLISAKNAEAETKTPKPERSDSWEFYGEDENE---EEDRDEEQEG 550
                        |.|....:.|:....:|      :|:|:.|.|..| .:|:   ....|:.|
Human   423 ------------ARARLSSAYLLGVPGSE------QPDRAGSLELRG-FKNKLYVAVVGDKVQ-- 466

  Fly   551 SSSPEPLYANQEATY---GKLFEMATAGSSRS------NVLTPNQVAEQQQLACITEDSELDACE 606
                  ||.|.|..:   |..|...:.|:.:.      ::.||.::......:.:.::..|:|.:
Human   467 ------LYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQ 525

  Fly   607 GAVG------------------------GVPLPQ-AVIEEFDPLSSKCS----------TLARSN 636
            ||:.                        |.|.|. |.|.....:..:|:          :..||.
Human   526 GAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSL 590

  Fly   637 KSNELLLLEHLLE---------EDTYGTVKAEQDDVSMCTSEEEPTTSAATSPKPQQPQIVHQNA 692
            |.:..:..|.|:|         .:.:........:..      :|::|.:|       :..|..|
Human   591 KMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEAL------QPSSSPST-------RRCHLEA 642

  Fly   693 RLLSDSMENMLDSDQERAKPYLSRMPESANKASGPVDLASASRNRTNWFVPDKASCSDVTPNTSK 757
            :        ..:....|..|......|.                       |||.|:.||.....
Human   643 K--------YREGKYRRYHPLFGNQEEL-----------------------DKALCAAVTTTDLA 676

  Fly   758 TTPPIEGDSPPTYLEAIGGSKDAAGNQENRS--TIGSRFRQTINAISNVKLKMDAMKRKASFRGA 820
            .|..:.|..        .|....:|:.|..:  .:..:..||        |:|:.::
Human   677 ETQALLGCG--------AGINCFSGDPEAPTPLALAEQAGQT--------LQMEFLR-------- 717

  Fly   821 NQRQSDVRVALQMVPR-PSLSPL---------LIRYEGPLVRFPSG--VVED--ILKEMQNRKAI 871
            |.|.::       ||| .|:.||         .:.:.|.|.:..|.  :::|  ..:|...|..:
Human   718 NNRTTE-------VPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCV 775

  Fly   872 LRERQFQTFLDQEMKTPREMIPLDTITTLQCVSNSRVTDTATHFY--CFEITTSQPKNGNGAGDA 934
            |.:.....|.::...||...|....|..|      .|....||.:  .||:.|.        |:.
Human   776 LGDGVLSYFENERAVTPNGEIRASEIVCL------AVPPPDTHGFEHTFEVYTE--------GER 826

  Fly   935 MSSNPNLLMTSSSSGNVKQQRVSHLYGVGKESERGVWMQKILESLT---------------NSLP 984
            :                      :|:|:....:...|::.|.::..               ..||
Human   827 L----------------------YLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLP 869

  Fly   985 VKYTCHYYRAGWCYLKNSITSEWSGTWLVLRKSQRRLIFVSEANGNVEK-MDLRKARCIVLKESD 1048
                   |:||.     |:.....| |..|..|:.|.:|   ..|..|: :.|||.:.:.::...
Human   870 -------YKAGL-----SLQRAQEG-WFSLSGSELRAVF---PEGPCEEPLQLRKLQELSIQGDS 918

  Fly  1049 ESIDNLHVESGPMLMIDCPPYAVYMIMSSARETKI----WRHIIREVAHNNGFSLGDQQLTRYDV 1109
            |:...:.||....|.|.             .|.::    |...|::.|.:.|.:|.:|||...|:
Human   919 ENQVLVLVERRRTLYIQ-------------GERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDI 970

  Fly  1110 PVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKLMSAFRADAFNVEITRNEYNEHDVANVLKRFM 1174
            ||||.:|::::...|..|||||||.|..:...:|:.:.|.||.:|.:...|.:..||::.||||:
Human   971 PVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFL 1035

  Fly  1175 RDLPERLL---GKLTDSFVFVTELAVASEKIPIYRELLARLSAIERETLRRIVGHLVFISSQQAK 1236
            ||||:.|.   .:||  ::..:|:....||:..|||||.||..:.|.|::.::.||..:......
Human  1036 RDLPDGLFTRAQRLT--WLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDT 1098

  Fly  1237 NKMSVQNLTMIWGPTLLAKKSDELIYSQKEADVLSDLVVLYKNLFPCSADEIKREQAMLACLQKY 1301
            |:|:|.||.:::||||.  ::|...|  |...|:.||:..|..:|....:|:::::..:..:.|.
Human  1099 NQMNVHNLAIVFGPTLF--QTDGQDY--KAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKM 1159

  Fly  1302 YAAAETLKDAVKQSGDIKIWISLNPNPENKTEEKTQVNATISPTKTAYELCREYSAKMQLPTHQ- 1365
            ..|...  ...:.:||....:.|.   |.|.|  |:.:..:..:.||.||..|...:..:...:
Human  1160 RVAGTA--SGTQHAGDFICTVYLE---EKKAE--TEQHIKVPASMTAEELTLEILDRRNVGIREK 1217

  Fly  1366 --LTLYEVILNDSLERPLHHDTKVFDVILNWSYWPEEDRKH-----NYLVVRPVEMLREIQRAVK 1423
              .|.:||...:..|||||...||..::            |     ::|||:..:.:..:...:.
Human  1218 DYWTCFEVNEREEAERPLHFAEKVLPIL------------HGLGTDSHLVVKKHQAMEAMLLYLA 1270

  Fly  1424 NLATVTPGKELRFADSRT-------------KTFKTLQCELRDGKIVVSKKDKNDKTTI----VR 1471
            :....|....::|.:.|:             :.|......||..|.|.|::..:.....    .:
Human  1271 SRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEK 1335

  Fly  1472 EIFLQSSTAYLGCERKRDFPWSWAITFVERTQAQIMRSRDAPFIGHVLAGSEWGDRTIWYSSI-- 1534
            |..::|...|||.::|...|..|..|.|..|:..                    ::..||...
Human  1336 EWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKH--------------------EKQQWYLCCDT 1380

  Fly  1535 ------WYCLY----RDNILPPAE 1548
                  |:..:    .|.::.|:|
Human  1381 QMELREWFATFLFVQHDGLVWPSE 1404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	68/184 (37%)
ARAP1	NP_001035207.1	SAM_Arap1,2,3	6..68	CDD:188889
		SAM	10..64	CDD:197735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..144		9/66 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..302		35/208 (17%)
		PH	328..419	CDD:278594	18/120 (15%)
		PH1_ARAP	329..421	CDD:270073	18/121 (15%)
		PH2_ARAP	436..525	CDD:270074	20/103 (19%)
		ArfGap	535..651	CDD:279720	17/136 (13%)
		PH3_ARAP	743..849	CDD:270076	24/141 (17%)
		PH	744..848	CDD:278594	24/139 (17%)
		PH4_ARAP	862..952	CDD:270077	25/118 (21%)
		RhoGAP_ARAP	956..1135	CDD:239850	68/184 (37%)
		RA	1172..1261	CDD:279168	26/105 (25%)
		PH5_ARAP	1263..1402	CDD:270079	24/158 (15%)
		PH	1299..1391	CDD:278594	20/111 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6508
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3872
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001278
OrthoInspector	1	1.000	-	-		otm42129
orthoMCL	1	0.900	-	-		OOG6_104434
Panther	1	1.100	-	-	LDO	PTHR45899
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3385
SonicParanoid	1	1.000	-	-		X1129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.850