DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP15B and ACAP3

DIOPT Version :9

Sequence 1:	NP_573183.2	Gene:	RhoGAP15B / 32686	FlyBaseID:	FBgn0030808	Length:	1552	Species:	Drosophila melanogaster
Sequence 2:	XP_011538908.1	Gene:	ACAP3 / 116983	HGNCID:	16754	Length:	844	Species:	Homo sapiens

Alignment Length:	362	Identity:	68/362 - (18%)
Similarity:	133/362 - (36%)	Gaps:	96/362 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1021 LIFVSEANGNVE-------KMDLRKARCIVLKESDESIDNLHVESGPMLMIDCPPYAVYMIMSSA 1078
            :|...:|..:|.       |.|:||     .||:.:..|.:..:               :.:|..
Human   103 MILFDQAQRSVRQQLQSFVKEDVRK-----FKETKKQFDKVRED---------------LELSLV 147

  Fly  1079 RETKIWRHIIREVAHNNGFSLGDQQLTRYDVPVIVDKCINFVYIHGSMSEGIYRKSGSENSMHKL 1143
            |..:..||...||..    :.|...|||        ||...:.:...:...:.:.......:..:
Human   148 RNAQAPRHRPHEVEE----ATGALTLTR--------KCFRHLALDYVLQINVLQAKKKFEILDSM 200

  Fly  1144 MSAFRADAFNVEITRNEYNEHDVANVLKRFMRDLPERLLGKLTDSFVFVTELAVASEKIPIYREL 1208
            :|...|.:...:      ..:.:.:.|..:|:.|...|...:.||         |.||    ||:
Human   201 LSFMHAQSSFFQ------QGYSLLHQLDPYMKKLAAELDQLVIDS---------AVEK----REM 246

  Fly  1209 LARLSAIERETLRRIVGHLVFISSQQAKNKMSV----------------QNLTMIWGPTLLAKKS 1257
            ..:.:||::.||      |...|..::|.:..|                .|....|.....:.::
Human   247 ERKHAAIQQRTL------LQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQN 305

  Fly  1258 DELIYSQKEADVLSDLVVLYKNLFPCS---ADEIKRE------QAMLACLQKYYAAAETLKDAVK 1313
            .:|:|.:|..|.|:   |:..:|..||   .::|:|.      ....:|:.:  |.:|.|:.|..
Human   306 SQLVYQKKLKDALT---VVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQ--ADSEKLRQAWV 365

  Fly  1314 QSGDIKIWISLNPNPENKTEEKTQVNATISPTKTAYE 1350
            |:....|..:...:|::...|:  ::.|.||:.::.:
Human   366 QAVQASIASAYRESPDSCYSER--LDRTASPSTSSID 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP15B	NP_573183.2	RhoGAP_ARAP	1095..1277	CDD:239850	35/197 (18%)
ACAP3	XP_011538908.1	BAR	16..225	CDD:299863	25/159 (16%)
		PH	279..373	CDD:278594	19/98 (19%)
		PH_ACAP	281..377	CDD:270070	20/100 (20%)
		ArfGap	413..531	CDD:279720
		ANK	711..>798	CDD:238125
		ANK repeat	712..743	CDD:293786
		Ank_4	715..766	CDD:290365
		ANK repeat	745..776	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810